TY - JOUR
T1 - A comprehensive SARS-CoV-2 and COVID-19 review, Part 1
T2 - Intracellular overdrive for SARS-CoV-2 infection
AU - Jamison, David A.
AU - Anand Narayanan, S.
AU - Trovão, Nídia S.
AU - Guarnieri, Joseph W.
AU - Topper, Michael J.
AU - Moraes-Vieira, Pedro M.
AU - Zaksas, Viktorija
AU - Singh, Keshav K.
AU - Wurtele, Eve Syrkin
AU - Beheshti, Afshin
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/8
Y1 - 2022/8
N2 - COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.
AB - COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.
UR - http://www.scopus.com/inward/record.url?scp=85130183632&partnerID=8YFLogxK
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U2 - 10.1038/s41431-022-01108-8
DO - 10.1038/s41431-022-01108-8
M3 - Review article
C2 - 35577935
AN - SCOPUS:85130183632
SN - 1018-4813
VL - 30
SP - 889
EP - 898
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
IS - 8
ER -