A Comprehensive review of risk factor, mechanism, and management of left ventricular assist device-Associated stroke

Sung Min Cho; Pouya Tahsili-Fahadan; Ahmet Kilic; Chun Woo Choi; Randall C. Starling; Ken Uchino

doi:10.1055/s-0041-1726328

A Comprehensive review of risk factor, mechanism, and management of left ventricular assist device-Associated stroke

Sung Min Cho, Pouya Tahsili-Fahadan, Ahmet Kilic, Chun Woo Choi, Randall C. Starling, Ken Uchino

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

The use of left ventricular assist devices (LVADs) has been increasing in the last decade, along with the number of patients with advanced heart failure refractory to medical therapy. Ischemic stroke and intracranial hemorrhage remain the leading causes of morbidity and mortality in LVAD patients. Despite the common occurrence and the significant outcome impact, underlying mechanisms and management strategies of stroke in LVAD patients are controversial. In this article, we review our current knowledge on pathophysiology and risk factors of LVAD-Associated stroke, outline the diagnostic approach, and discuss treatment strategies.

Original language	English (US)
Pages (from-to)	411-421
Number of pages	11
Journal	Seminars in neurology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1055/s-0041-1726328
State	Published - Aug 1 2021

Keywords

heart failure
intracranial hemorrhage
ischemic stroke
left ventricular assist device

ASJC Scopus subject areas

Neurology
Clinical Neurology

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AU - Starling, Randall C.

AU - Uchino, Ken

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N2 - The use of left ventricular assist devices (LVADs) has been increasing in the last decade, along with the number of patients with advanced heart failure refractory to medical therapy. Ischemic stroke and intracranial hemorrhage remain the leading causes of morbidity and mortality in LVAD patients. Despite the common occurrence and the significant outcome impact, underlying mechanisms and management strategies of stroke in LVAD patients are controversial. In this article, we review our current knowledge on pathophysiology and risk factors of LVAD-Associated stroke, outline the diagnostic approach, and discuss treatment strategies.

AB - The use of left ventricular assist devices (LVADs) has been increasing in the last decade, along with the number of patients with advanced heart failure refractory to medical therapy. Ischemic stroke and intracranial hemorrhage remain the leading causes of morbidity and mortality in LVAD patients. Despite the common occurrence and the significant outcome impact, underlying mechanisms and management strategies of stroke in LVAD patients are controversial. In this article, we review our current knowledge on pathophysiology and risk factors of LVAD-Associated stroke, outline the diagnostic approach, and discuss treatment strategies.

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KW - intracranial hemorrhage

KW - ischemic stroke

KW - left ventricular assist device

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A Comprehensive review of risk factor, mechanism, and management of left ventricular assist device-Associated stroke

Abstract

Keywords

ASJC Scopus subject areas

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