A comprehensive review of naloxone for the emergency physician

James M. Chamberlain, Bruce L. Klein

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Naloxone has enjoyed long-standing success as a safe and effective opioid antagonist and has been invaluable in defining the role of endogenous opioid pathways in the response to pathological states such as sepsis and hypovolemia. We look forward to exciting research to further elucidate these pathways and to improve outcome by modulating the patient's physiological response to these stresses.

Original languageEnglish (US)
Pages (from-to)650-660
Number of pages11
JournalAmerican Journal of Emergency Medicine
Issue number6
StatePublished - Nov 1994
Externally publishedYes


  • Naloxone
  • opioid antagonists
  • opioids

ASJC Scopus subject areas

  • Emergency Medicine


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