Abstract
Hypoxia-inducible factor 1 (HIF-1) is the founding member of a family of transcription factors that function as master regulators of oxygen homeostasis. HIF-1 is composed of an O2-regulated HIF-1α subunit and a constitutively expressed HIF-1β subunit. This review provides a compendium of proteins that interact with the HIF-1α subunit, many of which regulate HIF-1 activity in either an O2-dependent or O2-independent manner.
Original language | English (US) |
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Pages (from-to) | 128-135 |
Number of pages | 8 |
Journal | Experimental cell research |
Volume | 356 |
Issue number | 2 |
DOIs | |
State | Published - Jul 15 2017 |
Keywords
- Oxygen biology
- Transcriptional regulation
ASJC Scopus subject areas
- Cell Biology