TY - JOUR
T1 - A comparison of the growth suppressive effect of cortisone, prednisone, and other adrenal cortical hormones
AU - Van Metre, Thomas E.
AU - Niermann, William A.
AU - Rosen, Lawrence J.
N1 - Funding Information:
From the Pediatric Allergy Clinic and the Departments The Johns Hopkins Hospital and School of Medicine. Supported in part by the Maryland Division of the American Cancer Society, Institute of Allergy and infectious Diseases, U. S. Public Health Service (Training The Upjohn Company Fellowship Grant in Allergy and the Consolidated Gift atric Allergy Research of The Johns Hopkins HosGital. Presented at the sixteenth annual meeting of the American mood Beach, Fla., Jan. 11-13, 1960. Received for publication April 1960. *Assistant Professor of Pediatrics, Instructor in Medicine, School of Medicine: physician and pediatrician, The Johns **Instructor in Pediatrics, The Johns Hopkins University ***Upjohn Company Fellow in Pediatric Allergy. Department Hopkins University School of Medicine, 1958-1959. tCortisone was supplied as Cortone Acetate by Merck Pa., and as Cortisone Acetate by The Upjohn Company, (Deltasone), methylprednisolone (Medrol), and fluprednisolone drol) were supplied by The Upjohn Company, Triamcinolone Lederle Laboratories, Pearl River, Y.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1960
Y1 - 1960
N2 - Normal linear growth was noted in all of thirteen children given sufficient cortisone over a period of six months or longer to suppress asthma. Linear growth suppression was noted in twelve of thirteen children given prednisone, five of nine given methylprednisolone, the two given fluprednisolone, and in the one given triamcinolone, when sufficent corticosteroid was given for a similar period of time to produce the same degree of suppression of asthma. Evidence is presented indicating that cortisone is about one fifth as potent as prednisone and one sixth as potent as methylprednisolone as a therapeutic agent in asthma, but only one tenth as potent as each as a growth inhibiting agent.
AB - Normal linear growth was noted in all of thirteen children given sufficient cortisone over a period of six months or longer to suppress asthma. Linear growth suppression was noted in twelve of thirteen children given prednisone, five of nine given methylprednisolone, the two given fluprednisolone, and in the one given triamcinolone, when sufficent corticosteroid was given for a similar period of time to produce the same degree of suppression of asthma. Evidence is presented indicating that cortisone is about one fifth as potent as prednisone and one sixth as potent as methylprednisolone as a therapeutic agent in asthma, but only one tenth as potent as each as a growth inhibiting agent.
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U2 - 10.1016/0021-8707(60)90088-5
DO - 10.1016/0021-8707(60)90088-5
M3 - Article
C2 - 13780021
AN - SCOPUS:0000549377
SN - 0021-8707
VL - 31
SP - 531
EP - 542
JO - Journal of Allergy
JF - Journal of Allergy
IS - 6
ER -