A compact-size packaged third-order harmonic tag for intraocular pressure (IOP) monitoring inside a mouse eye

Dohyuk Ha, Tse Yu Lin, Wilhelmine N. De Vries, Byungguk Kim, Arthur L. Chlebowski, Simon W.M. John, Pedro P. Irazoqui, William J. Chappell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper shows measurement of intraocular pressure (IOP) within a mouse eye. Three main challenges faced the development of a device for the measurement: the size of the mouse eye, the depth of the anterior chamber where the device will be implanted, and the maximum allowable incision size. These factors all limit the size of the device. In addition, a novel detection scheme is required which enables detection of changes in IOP with high resolution. This paper presents the fabrication process of an ultra-small size Parylene tag in which a micro-electromechanical systems (MEMS) capacitive pressure sensor is packaged with a self-expandable Nitinol antenna and a diode. From the device implanted inside the mouse eye, a resonance frequency shift of the third-order harmonic signal was detected with a sensitivity of approximately L.5 MHz/mmHg at an 1L.5 cm distance from the sensor as the pressure inside the mouse eye changed. This work thus shows the feasibility of IOP monitoring using the third order harmonic from a device implanted inside the mouse eye.

Original languageEnglish (US)
Title of host publicationIMS 2012 - 2012 IEEE MTT-S International Microwave Symposium
DOIs
StatePublished - 2012
Externally publishedYes
Event2012 IEEE MTT-S International Microwave Symposium, IMS 2012 - Montreal, QC, Canada
Duration: Jun 17 2012Jun 22 2012

Publication series

NameIEEE MTT-S International Microwave Symposium Digest
ISSN (Print)0149-645X

Conference

Conference2012 IEEE MTT-S International Microwave Symposium, IMS 2012
Country/TerritoryCanada
CityMontreal, QC
Period6/17/126/22/12

Keywords

  • Implantable device
  • Intraocular pressure (IOP) sensor
  • Parylene
  • Small form factor packaging
  • Third-order harmonic

ASJC Scopus subject areas

  • Radiation
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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