TY - GEN
T1 - A compact-size packaged third-order harmonic tag for intraocular pressure (IOP) monitoring inside a mouse eye
AU - Ha, Dohyuk
AU - Lin, Tse Yu
AU - De Vries, Wilhelmine N.
AU - Kim, Byungguk
AU - Chlebowski, Arthur L.
AU - John, Simon W.M.
AU - Irazoqui, Pedro P.
AU - Chappell, William J.
PY - 2012
Y1 - 2012
N2 - This paper shows measurement of intraocular pressure (IOP) within a mouse eye. Three main challenges faced the development of a device for the measurement: the size of the mouse eye, the depth of the anterior chamber where the device will be implanted, and the maximum allowable incision size. These factors all limit the size of the device. In addition, a novel detection scheme is required which enables detection of changes in IOP with high resolution. This paper presents the fabrication process of an ultra-small size Parylene tag in which a micro-electromechanical systems (MEMS) capacitive pressure sensor is packaged with a self-expandable Nitinol antenna and a diode. From the device implanted inside the mouse eye, a resonance frequency shift of the third-order harmonic signal was detected with a sensitivity of approximately L.5 MHz/mmHg at an 1L.5 cm distance from the sensor as the pressure inside the mouse eye changed. This work thus shows the feasibility of IOP monitoring using the third order harmonic from a device implanted inside the mouse eye.
AB - This paper shows measurement of intraocular pressure (IOP) within a mouse eye. Three main challenges faced the development of a device for the measurement: the size of the mouse eye, the depth of the anterior chamber where the device will be implanted, and the maximum allowable incision size. These factors all limit the size of the device. In addition, a novel detection scheme is required which enables detection of changes in IOP with high resolution. This paper presents the fabrication process of an ultra-small size Parylene tag in which a micro-electromechanical systems (MEMS) capacitive pressure sensor is packaged with a self-expandable Nitinol antenna and a diode. From the device implanted inside the mouse eye, a resonance frequency shift of the third-order harmonic signal was detected with a sensitivity of approximately L.5 MHz/mmHg at an 1L.5 cm distance from the sensor as the pressure inside the mouse eye changed. This work thus shows the feasibility of IOP monitoring using the third order harmonic from a device implanted inside the mouse eye.
KW - Implantable device
KW - Intraocular pressure (IOP) sensor
KW - Parylene
KW - Small form factor packaging
KW - Third-order harmonic
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U2 - 10.1109/MWSYM.2012.6259672
DO - 10.1109/MWSYM.2012.6259672
M3 - Conference contribution
AN - SCOPUS:84866792009
SN - 9781467310871
T3 - IEEE MTT-S International Microwave Symposium Digest
BT - IMS 2012 - 2012 IEEE MTT-S International Microwave Symposium
T2 - 2012 IEEE MTT-S International Microwave Symposium, IMS 2012
Y2 - 17 June 2012 through 22 June 2012
ER -