A clinical trial of ipratropium bromide nasal spray in patients with perennial nonallergic rhinitis

Edwin A. Bronsky, Howard Druce, Steven R. Findlay, Frank C. Hampel, Harold Kaiser, Paul Ratner, Martin D. Valentine, Chester C. Wood

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Intranasal ipratropium bromide has been shown to significantly reduce rhinorrhea. Use of a freon-propelled intranasal preparation has resulted in side effects associated with the drying properties of the propellant. The purpose of the present trial was to study the safety and efficacy of a new isotonic aqueous ipratropium bromide nasal spray pump, specifically in patients with perennial nonallergic rhinitis. Two hundred thirty-three patients participated in an 8-week double-blind parallel comparison of ipratropium bromide nasal spray with its vehicle, a saline solution. Treatment with the ipratropium spray resulted in a 30% reduction in rhinorrhea; this reduction was significantly greater than that seen with the saline vehicle. There was a modest reduction in postnasal drip, sneezing, and congestion with both treatments, which may be attributable to the salutary effects of the saline solution. Patients also perceived a significant reduction in the degree to which rhinorrhea interfered with their daily activities and moods. Treatment was well tolerated, with no drug-related systemic adverse events and no evidence of nasal rebound on discontinuation of treatment. Minor, infrequent episodes of nasal dryness and epistaxis were the only significant adverse events reported; these did not limit treatment. (J ALLERGY CLIN IMMUNOL 1995;95:1117-22.).

Original languageEnglish (US)
Pages (from-to)1117-1122
Number of pages6
JournalThe Journal of allergy and clinical immunology
Issue number5 SUPPL.
StatePublished - May 1995
Externally publishedYes


  • Nonallergic rhinitis
  • efficacy
  • ipratropium
  • nasal spray
  • rhinorrhea
  • safety

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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