TY - GEN
T1 - A channelized hotelling observer study comparing cone-beam, fan-beam and parallel-hole collimation in99mTc-sestamibi myocardial SPECT with a heterogeneous phantom population
AU - Gilland, Karen L.
AU - Tsui, Benjamin M.W.
AU - Gullberg, Grant T.
PY - 2005
Y1 - 2005
N2 - This study compared parallel-hole (PH), fan-beam (FB) and cone-beam (CB) collimation acquisition methods for myocardial perfusion, 99mTc- sestamibi myocardial SPECT imaging. For the task of myocardial defect detection, the Channelized Hotelling observer (CHO) was used to compute the area under the ROC curve (AUC) in simulated SPECT images acquired using one of the following 5 single-detector acquisition methods: parallel-hole with 360° acquisition (PH360), parallel-hole with 180° acquisition (PH180), fan-beam with 360° acquisition (FB360), fan-beam with 225° acquisition (FB225), or cone-beam with 360° acquisition (CB360). Unlike previous studies comparing PH, FB and CB, this study simulated a population of phantoms with variations in anatomy, defects and 99mTc-sestamibi uptake, as seen in actual cardiac SPECT patient images. Monte Carlo simulations were used to generate low noise projection data. Data were scaled to the same total scan time and to clinical count levels before adding Poisson noise. They were reconstructed using iterative OSEM with attenuation correction at various parameter settings. A single short axis (SA) slice was extracted, low-pass filtered at various cutoff frequencies and then rescaled to integer pixel values ranging from 0-255. For each acquisition method, OSEM parameter setting and filter cutoff, the AUC was estimated from 720 images. At the optimum parameter settings, the CB360 method yielded the highest AUC, followed by FB360, FB225, PH180 and PH360. The difference in AUC between the CB360 method and the other methods was statistically significant (p<0.05).
AB - This study compared parallel-hole (PH), fan-beam (FB) and cone-beam (CB) collimation acquisition methods for myocardial perfusion, 99mTc- sestamibi myocardial SPECT imaging. For the task of myocardial defect detection, the Channelized Hotelling observer (CHO) was used to compute the area under the ROC curve (AUC) in simulated SPECT images acquired using one of the following 5 single-detector acquisition methods: parallel-hole with 360° acquisition (PH360), parallel-hole with 180° acquisition (PH180), fan-beam with 360° acquisition (FB360), fan-beam with 225° acquisition (FB225), or cone-beam with 360° acquisition (CB360). Unlike previous studies comparing PH, FB and CB, this study simulated a population of phantoms with variations in anatomy, defects and 99mTc-sestamibi uptake, as seen in actual cardiac SPECT patient images. Monte Carlo simulations were used to generate low noise projection data. Data were scaled to the same total scan time and to clinical count levels before adding Poisson noise. They were reconstructed using iterative OSEM with attenuation correction at various parameter settings. A single short axis (SA) slice was extracted, low-pass filtered at various cutoff frequencies and then rescaled to integer pixel values ranging from 0-255. For each acquisition method, OSEM parameter setting and filter cutoff, the AUC was estimated from 720 images. At the optimum parameter settings, the CB360 method yielded the highest AUC, followed by FB360, FB225, PH180 and PH360. The difference in AUC between the CB360 method and the other methods was statistically significant (p<0.05).
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U2 - 10.1109/NSSMIC.2005.1596646
DO - 10.1109/NSSMIC.2005.1596646
M3 - Conference contribution
AN - SCOPUS:33846634060
SN - 0780392213
SN - 9780780392212
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 1695
EP - 1699
BT - 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
T2 - Nuclear Science Symposium Conference Record, 2005 IEEE
Y2 - 23 October 2005 through 29 October 2005
ER -