A catalytic antibody elicited by a hapten of tetrahedral carbon-type

Tomoya Kitazume; Takashi Tsukamoto; Koutaro Yoshimura

doi:10.1039/C39940001355

A catalytic antibody elicited by a hapten of tetrahedral carbon-type

Tomoya Kitazume, Takashi Tsukamoto, Koutaro Yoshimura

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A monoclonal antibody, elicited by a α,α,α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.

Original language	English (US)
Pages (from-to)	1355-1356
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	11
DOIs	https://doi.org/10.1039/C39940001355
State	Published - Dec 1 1994
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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title = "A catalytic antibody elicited by a hapten of tetrahedral carbon-type",

abstract = "A monoclonal antibody, elicited by a α,α,α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.",

author = "Tomoya Kitazume and Takashi Tsukamoto and Koutaro Yoshimura",

year = "1994",

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doi = "10.1039/C39940001355",

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journal = "Chemical Communications",

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AU - Kitazume, Tomoya

AU - Tsukamoto, Takashi

AU - Yoshimura, Koutaro

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Y1 - 1994/12/1

N2 - A monoclonal antibody, elicited by a α,α,α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.

AB - A monoclonal antibody, elicited by a α,α,α′, α′-tetrafluoroketone hapten, acted as an enzyme-like catalyst for the hydrolysis of an analogous carbonate, demonstrating that the difluoromethylene unit can been used as an isostere and isoelectronic mimic for the oxygen atom in an ether.

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DO - 10.1039/C39940001355

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SP - 1355

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JO - Chemical Communications

JF - Chemical Communications

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A catalytic antibody elicited by a hapten of tetrahedral carbon-type

Abstract

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