A case study in pharmacologic colon imaging using principal curves in single-photon emission computed tomography

Brian S. Caffo; Ciprian M. Crainiceanu; Lijuan Deng; Craig W. Hendrix

doi:10.1198/016214508000000832

A case study in pharmacologic colon imaging using principal curves in single-photon emission computed tomography

Brian S. Caffo, Ciprian M. Crainiceanu, Lijuan Deng, Craig W. Hendrix

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In this article we are concerned with functional imaging of the colon to assess the kinetics of microbicide lubricants. The overarching goal is to understand the distribution of the lubricants in the colon. Such information is crucial for understanding the potential impact of microbicides on human immunodeficiency virus transmission. The experiment was conducted by imaging a radiolabeled lubricant distributed in the subject's colon. The tracer imaging was conducted via single-photon emission computed tomography, a noninvasive, in vivo functional imaging technique. We have developed a novel principal curve algorithm to construct a three-dimensional curve through the colon images. The algorithm was tested and debugged on several difficult two-dimensional images of familiar curves where the original principal curve algorithm does not apply. The final curve fit to the colon data is compared with experimental sigmoidoscope collection.

Original language	English (US)
Pages (from-to)	1470-1480
Number of pages	11
Journal	Journal of the American Statistical Association
Volume	103
Issue number	484
DOIs	https://doi.org/10.1198/016214508000000832
State	Published - Dec 2008

Keywords

Curve fitting
Medical imaging
Pharmacology
SPECT.
Smoothing

ASJC Scopus subject areas

Statistics and Probability
Statistics, Probability and Uncertainty

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10.1198/016214508000000832

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title = "A case study in pharmacologic colon imaging using principal curves in single-photon emission computed tomography",

abstract = "In this article we are concerned with functional imaging of the colon to assess the kinetics of microbicide lubricants. The overarching goal is to understand the distribution of the lubricants in the colon. Such information is crucial for understanding the potential impact of microbicides on human immunodeficiency virus transmission. The experiment was conducted by imaging a radiolabeled lubricant distributed in the subject's colon. The tracer imaging was conducted via single-photon emission computed tomography, a noninvasive, in vivo functional imaging technique. We have developed a novel principal curve algorithm to construct a three-dimensional curve through the colon images. The algorithm was tested and debugged on several difficult two-dimensional images of familiar curves where the original principal curve algorithm does not apply. The final curve fit to the colon data is compared with experimental sigmoidoscope collection.",

keywords = "Curve fitting, Medical imaging, Pharmacology, SPECT., Smoothing",

author = "Caffo, {Brian S.} and Crainiceanu, {Ciprian M.} and Lijuan Deng and Hendrix, {Craig W.}",

note = "Funding Information: Brian S. Caffo is Associate Professor (E-mail: bcaffo@jhsph.edu) and Ciprian M. Craineceanu is Assistant Professor, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205. Lijuan Deng is Researcher, Boston Scientific Corporation, Natick, MA 21205. Craig W. Hendrix is Director of Drug Development Unit, Associate Professor, Division of Clincal Pharmacology and Infectious Diseases, Johns Hopkins Medicine, 615 N. Wolfe Street, Baltimore, MD 21205. This work was supported by the National Institutes of Health grant K25EB003491 and the Centers for Disease Control and Prevention grant 200-2001-08015.",

year = "2008",

month = dec,

doi = "10.1198/016214508000000832",

language = "English (US)",

volume = "103",

pages = "1470--1480",

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PY - 2008/12

Y1 - 2008/12

N2 - In this article we are concerned with functional imaging of the colon to assess the kinetics of microbicide lubricants. The overarching goal is to understand the distribution of the lubricants in the colon. Such information is crucial for understanding the potential impact of microbicides on human immunodeficiency virus transmission. The experiment was conducted by imaging a radiolabeled lubricant distributed in the subject's colon. The tracer imaging was conducted via single-photon emission computed tomography, a noninvasive, in vivo functional imaging technique. We have developed a novel principal curve algorithm to construct a three-dimensional curve through the colon images. The algorithm was tested and debugged on several difficult two-dimensional images of familiar curves where the original principal curve algorithm does not apply. The final curve fit to the colon data is compared with experimental sigmoidoscope collection.

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KW - SPECT.

KW - Smoothing

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A case study in pharmacologic colon imaging using principal curves in single-photon emission computed tomography

Abstract

Keywords

ASJC Scopus subject areas

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