A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies

Paul A. Gurbel; Christopher S. MacCord; R. David Anderson; Helen Scott; Dan Atar; Wolfgang Mergner; William R. Herzog

doi:10.1159/000176322

A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies

Paul A. Gurbel, Christopher S. MacCord, R. David Anderson, Helen Scott, Dan Atar, Wolfgang Mergner, William R. Herzog

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A model of coronary artery thrombosis which: (1) provides a stable thrombus; (2) incorporates intimal injury; (3) has a low mortality rate; (4) responds predictably to thrombolytic therapy, and (5) is technically simple, was developed. Intimal injury was produced proximal to a critical stenosis and followed by the infusion of a blood and thrombin mixture into the injured segment. After thrombus formation flow remained absent in all control animals (n = 7). Microscopy showed intimal injury and coronary thrombosis with platelets adherent to the subendothelium. In animals treated with tissue plasminogen activator (n = 7) flow returned to > 60% of baseline at 20.2 ± 7.7 min and was cyclical. Mortality and complications were infrequent. This model is useful in investigations of reperfusion therapy.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Cardiology (Switzerland)
Volume	84
Issue number	1
DOIs	https://doi.org/10.1159/000176322
State	Published - 1994
Externally published	Yes

Keywords

Coronary thrombosis
Model
Reperfusion
Thrombolysis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Pharmacology (medical)

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10.1159/000176322

Cite this

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AU - Gurbel, Paul A.

AU - MacCord, Christopher S.

AU - David Anderson, R.

AU - Scott, Helen

AU - Atar, Dan

AU - Mergner, Wolfgang

AU - Herzog, William R.

PY - 1994

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A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies

Abstract

Keywords

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