A broad survey of cathepsin k immunoreactivity in human neoplasms

Gang Zheng; Guido Martignoni; Cristina Antonescu; Elizabeth Montgomery; Charles Eberhart; George Netto; Janis Taube; William Westra; Jonathan I. Epstein; Tamara Lotan; Anirban Maitra; Edward Gabrielson; Michael Torbenson; Christine Iacobuzio-Donahue; Angelo Demarzo; Ie Ming Shih; Peter Illei; T. C. Wu; Pedram Argani

doi:10.1309/AJCPDTRTO2Z4UEXD

A broad survey of cathepsin k immunoreactivity in human neoplasms

Gang Zheng, Guido Martignoni, Cristina Antonescu, Elizabeth Montgomery, Charles Eberhart, George Netto, Janis Taube, William Westra, Jonathan I. Epstein, Tamara Lotan, Anirban Maitra, Edward Gabrielson, Michael Torbenson, Christine Iacobuzio-Donahue, Angelo Demarzo, Ie Ming Shih, Peter Illei, T. C. Wu, Pedram Argani

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

Original language	English (US)
Pages (from-to)	151-159
Number of pages	9
Journal	American journal of clinical pathology
Volume	139
Issue number	2
DOIs	https://doi.org/10.1309/AJCPDTRTO2Z4UEXD
State	Published - Feb 2013

Keywords

Cathepsin K
Immunohistochemistry
TFE3
TFEB

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/AJCPDTRTO2Z4UEXD

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Zheng, G., Martignoni, G., Antonescu, C., Montgomery, E., Eberhart, C., Netto, G., Taube, J., Westra, W., Epstein, J. I., Lotan, T., Maitra, A., Gabrielson, E., Torbenson, M., Iacobuzio-Donahue, C., Demarzo, A., Shih, I. M., Illei, P., Wu, T. C., & Argani, P. (2013). A broad survey of cathepsin k immunoreactivity in human neoplasms. American journal of clinical pathology, 139(2), 151-159. https://doi.org/10.1309/AJCPDTRTO2Z4UEXD

Zheng, G, Martignoni, G, Antonescu, C, Montgomery, E, Eberhart, C, Netto, G, Taube, J, Westra, W, Epstein, JI , Lotan, T, Maitra, A, Gabrielson, E, Torbenson, M, Iacobuzio-Donahue, C, Demarzo, A , Shih, IM , Illei, P , Wu, TC & Argani, P 2013, 'A broad survey of cathepsin k immunoreactivity in human neoplasms', American journal of clinical pathology, vol. 139, no. 2, pp. 151-159. https://doi.org/10.1309/AJCPDTRTO2Z4UEXD

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title = "A broad survey of cathepsin k immunoreactivity in human neoplasms",

abstract = "Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.",

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author = "Gang Zheng and Guido Martignoni and Cristina Antonescu and Elizabeth Montgomery and Charles Eberhart and George Netto and Janis Taube and William Westra and Epstein, {Jonathan I.} and Tamara Lotan and Anirban Maitra and Edward Gabrielson and Michael Torbenson and Christine Iacobuzio-Donahue and Angelo Demarzo and Shih, {Ie Ming} and Peter Illei and Wu, {T. C.} and Pedram Argani",

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doi = "10.1309/AJCPDTRTO2Z4UEXD",

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AU - Zheng, Gang

AU - Martignoni, Guido

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AU - Netto, George

AU - Taube, Janis

AU - Westra, William

AU - Epstein, Jonathan I.

AU - Lotan, Tamara

AU - Maitra, Anirban

AU - Gabrielson, Edward

AU - Torbenson, Michael

AU - Iacobuzio-Donahue, Christine

AU - Demarzo, Angelo

AU - Shih, Ie Ming

AU - Illei, Peter

AU - Wu, T. C.

AU - Argani, Pedram

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N2 - Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

AB - Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

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A broad survey of cathepsin k immunoreactivity in human neoplasms

Abstract

Keywords

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