A broad survey of cathepsin k immunoreactivity in human neoplasms

Gang Zheng; Guido Martignoni; Cristina Antonescu; Elizabeth A Montgomery; Charles Eberhart; Georges J Netto; Janis Taube; William H Westra; Jonathan I. Epstein; Tamara Lotan; Anirban Maitra; Edward Gabrielson; Michael S Torbenson; Christine Iacobuzio-Donahue; Angelo Demarzo; Ie Ming Shih; Peter Illei; T. C. Wu; Pedram Argani

doi:10.1309/AJCPDTRTO2Z4UEXD

A broad survey of cathepsin k immunoreactivity in human neoplasms

Gang Zheng, Guido Martignoni, Cristina Antonescu, Elizabeth A Montgomery, Charles Eberhart, Georges J Netto, Janis Taube, William H Westra, Jonathan I. Epstein, Tamara Lotan, Anirban Maitra, Edward Gabrielson, Michael S Torbenson, Christine Iacobuzio-Donahue, Angelo Demarzo, Ie Ming Shih, Peter Illei, T. C. Wu, Pedram Argani

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

Original language	English (US)
Pages (from-to)	151-159
Number of pages	9
Journal	American journal of clinical pathology
Volume	139
Issue number	2
DOIs	https://doi.org/10.1309/AJCPDTRTO2Z4UEXD
State	Published - Feb 2013

Keywords

Cathepsin K
Immunohistochemistry
TFE3
TFEB

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/AJCPDTRTO2Z4UEXD

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Zheng, G., Martignoni, G., Antonescu, C., Montgomery, E. A., Eberhart, C., Netto, G. J., Taube, J., Westra, W. H., Epstein, J. I., Lotan, T., Maitra, A., Gabrielson, E., Torbenson, M. S., Iacobuzio-Donahue, C., Demarzo, A., Shih, I. M., Illei, P., Wu, T. C., & Argani, P. (2013). A broad survey of cathepsin k immunoreactivity in human neoplasms. American journal of clinical pathology, 139(2), 151-159. https://doi.org/10.1309/AJCPDTRTO2Z4UEXD

Zheng, G, Martignoni, G, Antonescu, C, Montgomery, EA, Eberhart, C, Netto, GJ, Taube, J, Westra, WH, Epstein, JI , Lotan, T, Maitra, A, Gabrielson, E, Torbenson, MS, Iacobuzio-Donahue, C, Demarzo, A , Shih, IM , Illei, P , Wu, TC & Argani, P 2013, 'A broad survey of cathepsin k immunoreactivity in human neoplasms', American journal of clinical pathology, vol. 139, no. 2, pp. 151-159. https://doi.org/10.1309/AJCPDTRTO2Z4UEXD

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title = "A broad survey of cathepsin k immunoreactivity in human neoplasms",

abstract = "Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.",

keywords = "Cathepsin K, Immunohistochemistry, TFE3, TFEB",

author = "Gang Zheng and Guido Martignoni and Cristina Antonescu and Montgomery, {Elizabeth A} and Charles Eberhart and Netto, {Georges J} and Janis Taube and Westra, {William H} and Epstein, {Jonathan I.} and Tamara Lotan and Anirban Maitra and Edward Gabrielson and Torbenson, {Michael S} and Christine Iacobuzio-Donahue and Angelo Demarzo and Shih, {Ie Ming} and Peter Illei and Wu, {T. C.} and Pedram Argani",

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doi = "10.1309/AJCPDTRTO2Z4UEXD",

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AU - Zheng, Gang

AU - Martignoni, Guido

AU - Antonescu, Cristina

AU - Montgomery, Elizabeth A

AU - Eberhart, Charles

AU - Netto, Georges J

AU - Taube, Janis

AU - Westra, William H

AU - Epstein, Jonathan I.

AU - Lotan, Tamara

AU - Maitra, Anirban

AU - Gabrielson, Edward

AU - Torbenson, Michael S

AU - Iacobuzio-Donahue, Christine

AU - Demarzo, Angelo

AU - Shih, Ie Ming

AU - Illei, Peter

AU - Wu, T. C.

AU - Argani, Pedram

PY - 2013/2

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N2 - Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

AB - Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.

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A broad survey of cathepsin k immunoreactivity in human neoplasms

Abstract

Keywords

ASJC Scopus subject areas

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