Abstract
Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5319-5321 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 49 |
| Issue number | 46 |
| DOIs | |
| State | Published - May 14 2013 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry