TY - JOUR
T1 - A 4-year old presenting with fever and achiness
AU - Plott, Caroline
AU - Gracie, Thomas
AU - Alvis, Courtney
AU - Schlefman, Amanda
AU - Dudas, Robert
N1 - Funding Information:
We are grateful for the contributions of the patient and her family to this report. We are appreciative for the renal biopsy images from the Anatomic Pathology division at Johns Hopkins All Children’s Hospital. The author(s) received no financial support for the research, authorship, and/or publication of this article.
Publisher Copyright:
© The Author(s) 2021.
PY - 2021
Y1 - 2021
N2 - In children under the age of 5 who have abnormalities in history, physical examination, and laboratory studies indicating multi-system disease, uncovering the correct diagnosis is challenging. Here, we report the course of a 4-year-old girl who presented with a change in behavior, fever, arthralgia, arthritis, and hematuria following three recent hospitalizations for pneumonia and impetigo. Serologic findings were suggestive of a rheumatologic etiology and a renal biopsy was consistent with Membranous Lupus Nephritis Class V which helped secure the diagnosis of pediatric systemic lupus erythematosus. We review the clinical features and diagnostic criteria of early-onset systemic lupus erythematosus and discuss diagnostic considerations and prognosis.
AB - In children under the age of 5 who have abnormalities in history, physical examination, and laboratory studies indicating multi-system disease, uncovering the correct diagnosis is challenging. Here, we report the course of a 4-year-old girl who presented with a change in behavior, fever, arthralgia, arthritis, and hematuria following three recent hospitalizations for pneumonia and impetigo. Serologic findings were suggestive of a rheumatologic etiology and a renal biopsy was consistent with Membranous Lupus Nephritis Class V which helped secure the diagnosis of pediatric systemic lupus erythematosus. We review the clinical features and diagnostic criteria of early-onset systemic lupus erythematosus and discuss diagnostic considerations and prognosis.
KW - Rheumatology/clinical immunology
KW - nephrology
KW - pathology
UR - http://www.scopus.com/inward/record.url?scp=85118305406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85118305406&partnerID=8YFLogxK
U2 - 10.1177/2050313X211056416
DO - 10.1177/2050313X211056416
M3 - Article
C2 - 34733521
AN - SCOPUS:85118305406
SN - 2050-313X
VL - 9
JO - SAGE Open Medical Case Reports
JF - SAGE Open Medical Case Reports
ER -