A 4-year old presenting with fever and achiness

Caroline Plott, Thomas Gracie, Courtney Alvis, Amanda Schlefman, Robert Dudas

Research output: Contribution to journalArticlepeer-review


In children under the age of 5 who have abnormalities in history, physical examination, and laboratory studies indicating multi-system disease, uncovering the correct diagnosis is challenging. Here, we report the course of a 4-year-old girl who presented with a change in behavior, fever, arthralgia, arthritis, and hematuria following three recent hospitalizations for pneumonia and impetigo. Serologic findings were suggestive of a rheumatologic etiology and a renal biopsy was consistent with Membranous Lupus Nephritis Class V which helped secure the diagnosis of pediatric systemic lupus erythematosus. We review the clinical features and diagnostic criteria of early-onset systemic lupus erythematosus and discuss diagnostic considerations and prognosis.

Original languageEnglish (US)
JournalSAGE Open Medical Case Reports
StatePublished - 2021


  • Rheumatology/clinical immunology
  • nephrology
  • pathology

ASJC Scopus subject areas

  • General Medicine


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