9. The neural basis of interference resolution: Manipulations of interference

S. A. Bunge, A. Matsumoto, J. E. Desmond, G. H. Glover, J. D.E. Gabrieli

Research output: Contribution to journalArticlepeer-review


The goal of this experiment was to investigate the neural basis of interference resolution within WM through separate manipulations of WM load and interference in Sternberg's Item Recognition paradigm. We acquired whole-brain fMRI data for eight young volunteers while they performed blocks of four different Item Recognition trial types: Load1 (Baseline), Load4 Low Recency (LR), Load4 High Recency (HR), and Load6. Both the load manipulation and, to a lesser extent, the interference manipulation resulted in slowing of response times. The interference manipulation was associated with greater brain activation than the load manipulation in a number of brain regions including dorsolateral prefrontal and anterior cingulate cortices. These results suggest that interference resolution involves specific prefrontal circuits that cannot be accounted for simply by WM task difficulty.

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalBrain and Cognition
Issue number1-2
StatePublished - Dec 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience


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