8-Hydroxyquinoline: Chronic toxicity and inhibitory effect on the carcinogenicity of N-2-fluorenylacetamide

R. S. Yamamoto, G. M. Williams, H. H. Frankel, J. H. Weisburger

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Administration of 0.8% 8-hydroxyquinoline in Wayne laboratory meal to 6-wk-old male Fischer strain rats for periods up to 18 mo resulted in reduced body weight gain compared with that of controls, but no significant difference in the incidence of neoplasia. A striking effect of the compound was its rapid induction of hemosiderosis in the liver and spleen and eventually also in the heart, kidneys, testes, adrenal glands, pancreas, and thyroid. A notable feature of the iron deposition was that it was excluded from the neoplastic cells of hepatomas and hyperplastic nodules occurring in livers in which parenchymal cells contained heavy deposits. 8-Hydroxyquinoline reduced the toxicity of N-2-fluorenylacetamide. In addition, administration of 0.8% 8-hydroxyquinoline together with 0.02% N-2-fluorenylacetamide led to a lower incidence of hepatic malignancies than when the carcinogen was fed alone in a time-limited test series. This reduction of the carcinogenicity of N-2-fluorenylacetamide was also reflected by increased survival time of rats fed 8-hydroxyquinoline together with the carcinogen compared to those fed the carcinogen alone.

Original languageEnglish (US)
Pages (from-to)687-698
Number of pages12
JournalToxicology and Applied Pharmacology
Volume19
Issue number4
DOIs
StatePublished - Aug 1971

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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