7-Hexagon Multifocal Electroretinography for an Objective Functional Assessment of the Macula in 14 Seconds

Etienne M. Schönbach, Voraporn Chaikitmongkol, Rachel Annam, Emma C. McDonnell, Yulia Wolfson, Emily Fletcher, Hendrik P.N. Scholl

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Purpose: We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity. Methods: Healthy participants underwent mfERG testing according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards using the Espion Profile/D310 multifocal ERG system (Diagnosys, LLC, Lowell, MA, USA). One standard recording of a 61-hexagon array and 2 repeated recordings of a custom 7-hexagon array were obtained. Results: A total of 13 subjects (mean age 46.9 years) were included. The median response densities were 12.5 nV/deg2 in the center and 5.2 nV/deg2 in the periphery. Intereye correlations were strong in both the center (ρCenter = 0.821; p < 0.0001) and the periphery (ρPeriphery = 0.862; p < 0.0001). Intraeye correlations were even stronger: ρCenter = 0.904 with p < 0.0001 and ρPeriphery = 0.955 with p < 0.0001. Bland-Altman plots demonstrated an acceptable retest mean difference in both the center and periphery, and narrow limits of agreement. We found strong correlations of the center (ρCenter = 0.826; p < 0.0001) and periphery (ρPeriphery = 0.848; p < 0.0001), with recordings obtained by the 61-hexagon method. Conclusions: The 7-hexagon mfERG provides reproducible results in agreement with results obtained according to the ISCEV standard.

Original languageEnglish (US)
Pages (from-to)117-124
Number of pages8
JournalOphthalmic Research
Issue number2
StatePublished - Jul 1 2017


  • Dystrophy
  • Full-field electroretinogram
  • Macular degeneration
  • Multifocal electroretinogram
  • Outcome parameters
  • Reproducibility
  • Retina
  • Validity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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