Abstract
The displacement of 3H-diprenorphine from opiate receptors by mu-selective opiates was measured in the mouse striatum and thalamus in vivo. In addition, the regional distribution of opiate receptor binding using 3H-diprenorphine, 3H-naloxone and 3H-lofentanil was measured. The displacement of 3H-diprenorphine by naloxone and carfentanil in vivo showed no differences in the striatum and thalamus suggesting that 3H-diprenorphine binds only to one opiate receptor subtype in vivo. This finding is substantiated by the observation that the mu selective ligands 3H-naloxone and 3H-lofentanil have the same in vivo distribution of receptor binding as 3H-diprenorphine. The implication of these findings for PET imaging of opiate receptor subtypes is discussed.
Original language | English (US) |
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Pages (from-to) | 1597-1606 |
Number of pages | 10 |
Journal | Life Sciences |
Volume | 38 |
Issue number | 17 |
DOIs | |
State | Published - Apr 28 1986 |
ASJC Scopus subject areas
- Pharmacology