3D simulations of radiotracer uptake in deep nuclei of human brain

O. Rousset; Y. Ma; M. Kamber; A. C. Evans

doi:10.1016/0895-6111(93)90031-H

3D simulations of radiotracer uptake in deep nuclei of human brain

O. Rousset, Y. Ma, M. Kamber, A. C. Evans

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radio-labelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [¹⁸F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).

Original language	English (US)
Pages (from-to)	373-379
Number of pages	7
Journal	Computerized Medical Imaging and Graphics
Volume	17
Issue number	4-5
DOIs	https://doi.org/10.1016/0895-6111(93)90031-H
State	Published - 1993
Externally published	Yes

Keywords

Partial volume
Positron emission tomography (PET)
Simulation
Spillover effect
Tracer uptake

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Computer Vision and Pattern Recognition
Health Informatics
Computer Graphics and Computer-Aided Design

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10.1016/0895-6111(93)90031-H

Cite this

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title = "3D simulations of radiotracer uptake in deep nuclei of human brain",

abstract = "The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radio-labelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).",

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T1 - 3D simulations of radiotracer uptake in deep nuclei of human brain

AU - Rousset, O.

AU - Ma, Y.

AU - Kamber, M.

AU - Evans, A. C.

PY - 1993

Y1 - 1993

N2 - The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radio-labelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).

AB - The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radio-labelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).

KW - Partial volume

KW - Positron emission tomography (PET)

KW - Simulation

KW - Spillover effect

KW - Tracer uptake

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ER -

3D simulations of radiotracer uptake in deep nuclei of human brain

Abstract

Keywords

ASJC Scopus subject areas

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