3D simulations of radiotracer uptake in deep nuclei of human brain

O. Rousset, Y. Ma, M. Kamber, A. C. Evans

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The accuracy of Positron Emission Tomography (PET) for measuring in vivo concentrations of radio-labelled pharmaceuticals is affected by the limited tomograph resolution. Using computer simulations, we developed a model reproducing the distribution of the tracer [18F]FJfluoroDOPA which is specifically taken up in the normal human striatum. Validation of the model was performed by comparing the simulated images with real PET scans of the same brain. The simulation was used to examine the effect of axial displacement of the brain relative to the PET imaging planes, and that of image contrast on signal recovery (partial volume effects).

Original languageEnglish (US)
Pages (from-to)373-379
Number of pages7
JournalComputerized Medical Imaging and Graphics
Issue number4-5
StatePublished - 1993
Externally publishedYes


  • Partial volume
  • Positron emission tomography (PET)
  • Simulation
  • Spillover effect
  • Tracer uptake

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design


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