Abstract
We have developed a fast 3D photoacoustic imaging system based on a sparse array of ultrasound detectors and iterative image reconstruction. To investigate the high frame rate capabilities of our system in the context of rotational motion, flow, and spectroscopy, we performed high frame-rate imaging on a series of targets, including a rotating graphite rod, a bolus of methylene blue flowing through a tube, and hyper-spectral imaging of a tube filled with methylene blue under a no flow condition. Our frame-rate for image acquisition was 10 Hz, which was limited by the laser repetition rate. We were able to track the rotation of the rod and accurately estimate its rotational velocity, at a rate of 0.33 rotations-per-second. The flow of contrast in the tube, at a flow rate of 180 μL/min, was also well depicted, and quantitative analysis suggested a potential method for estimating flow velocity from such measurements. The spectrum obtained did not provide accurate results, but depicted the spectral absorption signature of methylene blue, which may be sufficient for identification purposes. These preliminary results suggest that our high frame-rate photoacoustic imaging system could be used for identifying contrast agents and monitoring kinetics as an agent propagates through specific, simple structures such as blood vessels.
Original language | English (US) |
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Article number | 71770W |
Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
Volume | 7177 |
DOIs | |
State | Published - 2009 |
Externally published | Yes |
Event | Photons Plus Ultrasound: Imaging and Sensing 2009 - San Jose, CA, United States Duration: Jan 25 2009 → Jan 28 2009 |
Keywords
- Flow measurements
- Hyper-spectral imaging
- Image reconstruction algorithm
- Photoacoustic imaging
- Real-time imaging
- Sparse array
- Three-dimensional imaging
- Ultrasound detector array
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging