3D left ventricular strain from unwrapped harmonic phase measurements

Bharath Ambale Venkatesh, Himanshu Gupta, Steven G. Lloyd, Louis Dell'Italia, Thomas S. Denney

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Purpose: To validate a method for measuring 3D left ventricular (LV) strain from phase-unwrapped harmonic phase (HARP) images derived from tagged cardiac magnetic resonance imaging (MRI). Materials and Methods: A set of 40 human subjects were imaged with tagged MRI. In each study the HARP phase was computed and unwrapped in each short-axis and long-axis image. Inconsistencies in unwrapped phase were resolved using branch cuts manually placed with a graphical user interface. 3D strain maps were computed for all imaged timeframes in each study. The strain from unwrapped phase (SUP) and displacements were compared to those estimated by a feature-based (FB) technique and a HARP technique. Results: 3D strain was computed in each timeframe through systole and mid-diastole in ≈30 minutes per study. The standard deviation of the difference between strains measured by the FB and the SUP methods was less than 5% of the average of the strains from the two methods. The correlation between peak circumferential strain measured using the SUP and HARP techniques was over 83%. Conclusion: The SUP technique can reconstruct full 3D strain maps from tagged MR images through the cardiac cycle in a reasonable amount of time and user interaction compared to other 3D analysis methods.

Original languageEnglish (US)
Pages (from-to)854-862
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Issue number4
StatePublished - Apr 2010
Externally publishedYes


  • 3D strain
  • Branch cuts
  • Harmonic phase
  • Left ventricle
  • Phase unwrapping
  • Tagged magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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