3d bolus tracking with frequency-shifted burst mri

Jeff H. Duyn, Peter Van Gelderen, Peter Barker, Joseph A. Frank, Venkata S. Mattay, Chrit T.W. Moonen

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Objective: Our goal was to develop and test a 3D bolus-tracking MR technique for perfusion imaging of normal and pathological (infarcted) human brain. Materials and Methods: All experiments were performed on standard 1.5 T GE/Signa clinical scanners. Five normal volunteers and one patient with a subacute brain infarct were studied. Modified [frequency-shifted (FS)] BURST MRI was performed during injection of a bolus of Gd-DTPA (0.13 mmol/kg) in the antecubital vein. The 3D datasets were acquired with a time resolution of 2.2 s and an effective spatial resolution of 4.3 x 4.3 x 6.4 mm. Three-dimensional maps of blood volume and bolus arrival time were determined by fitting a synthetic curve to the intensity time course on a voxel-by-voxel basis. Results: Both relative cerebral blood volume and arrival time maps demonstrated sensitivity to regional differences in blood supply in both normal brain and in the subacute brain infarction. The transit time maps showed arrival time delays of 5-7 s within and around the infarct and confirmed the diagnosis of left middle cerebral artery occlusion. Conclusion: The results of the measurements on both normal and diseased human brain demonstrated the ability to acquire valuable 3D information about brain perfusion using FS BURST MRI.

Original languageEnglish (US)
Pages (from-to)680-687
Number of pages8
JournalJournal of computer assisted tomography
Issue number5
StatePublished - 1994


  • Arteries occlusion
  • Brain
  • Brain perfusion
  • Magnetic resonance imaging techniques

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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