3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain

G. A. Ricaurte; K. F. Finnegan; D. E. Nichols; L. E. DeLanney; I. Irwin; J. W. Langston

doi:10.1016/0014-2999(87)90233-0

3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain

G. A. Ricaurte, K. F. Finnegan, D. E. Nichols, L. E. DeLanney, I. Irwin, J. W. Langston

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Abstract

The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic neurons in the rat brain. It was found that MDE produced a long-lasting, dose-related depletion of serotonin (5HT). However, even at high dosage, MDE did not reduce the concentration of either dopamine (DA) or norepinephrine (NE) on a long-term basis. When compared to 3,4-methylenedioxymethylamphetamine (MDMA), MDE was approximately one fourth as potent as producing a long-term depletion of 5HT. These results suggest that MDE, like MDMA, may be selectively toxic to central serotonergic neurons.

Original language	English (US)
Pages (from-to)	265-268
Number of pages	4
Journal	European Journal of Pharmacology
Volume	137
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(87)90233-0
State	Published - Jun 4 1987
Externally published	Yes

Keywords

Amphetamines (and analogues)
Neurotoxicity
Serotonergic neurons

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(87)90233-0

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title = "3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain",

abstract = "The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic neurons in the rat brain. It was found that MDE produced a long-lasting, dose-related depletion of serotonin (5HT). However, even at high dosage, MDE did not reduce the concentration of either dopamine (DA) or norepinephrine (NE) on a long-term basis. When compared to 3,4-methylenedioxymethylamphetamine (MDMA), MDE was approximately one fourth as potent as producing a long-term depletion of 5HT. These results suggest that MDE, like MDMA, may be selectively toxic to central serotonergic neurons.",

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AU - Ricaurte, G. A.

AU - Finnegan, K. F.

AU - Nichols, D. E.

AU - DeLanney, L. E.

AU - Irwin, I.

AU - Langston, J. W.

PY - 1987/6/4

Y1 - 1987/6/4

N2 - The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic neurons in the rat brain. It was found that MDE produced a long-lasting, dose-related depletion of serotonin (5HT). However, even at high dosage, MDE did not reduce the concentration of either dopamine (DA) or norepinephrine (NE) on a long-term basis. When compared to 3,4-methylenedioxymethylamphetamine (MDMA), MDE was approximately one fourth as potent as producing a long-term depletion of 5HT. These results suggest that MDE, like MDMA, may be selectively toxic to central serotonergic neurons.

AB - The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic neurons in the rat brain. It was found that MDE produced a long-lasting, dose-related depletion of serotonin (5HT). However, even at high dosage, MDE did not reduce the concentration of either dopamine (DA) or norepinephrine (NE) on a long-term basis. When compared to 3,4-methylenedioxymethylamphetamine (MDMA), MDE was approximately one fourth as potent as producing a long-term depletion of 5HT. These results suggest that MDE, like MDMA, may be selectively toxic to central serotonergic neurons.

KW - Amphetamines (and analogues)

KW - Neurotoxicity

KW - Serotonergic neurons

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3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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