2-Methoxyestradiol, an endogenous metabolite of 17β-estradiol, inhibits adipocyte proliferation

Catalina Picó, Pere Puigserver, Paula Oliver, Andren Palou

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The effects of 2-methoxyestradiol (2ME), a naturally occurring mammalian metabolite of 17β-estradiol, on adipocyte growth has been investigated in mouse brown adipose tissue precursor cells developed in primary culture. 2ME inhibits brown adipocyte proliferation in a dose-response manner (IC50 = 1.7 x 10-6 for DNA synthesis), with much higher potency than its hormone precursor 17β-estradiol, and cells acquire the typical differentiated morphology - more round with a higher content of triglycerides. 2ME causes similar effects in the immortal brown adipocyte tumor-derived hibernoma cell line HIB 1B and the immortal 3T3-F442A white adipocyte line. These findings suggest a possible role for 2ME in adipocyte proliferation, and probably in the differentiation process, entering the cells in the adipogenic program.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - 1998
Externally publishedYes


  • 2-Methoxyestradiol
  • Adipocytes
  • Cell proliferation
  • Cultured brown adipocytes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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