2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir

F. M. Hamzeh; T. Spector; P. S. Lietman

doi:10.1128/AAC.37.3.602

2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir

F. M. Hamzeh, T. Spector, P. S. Lietman

Research output: Contribution to journal › Comment/debate › peer-review

10 Scopus citations

Abstract

We studied the effects of 2-acetylpyridine 5- [(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81 or A1110U), a potent inhibitor of the ribonucleotide reductases encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus, against human cytomegalovirus (HCMV) replication in infected MRC-5 cells. We show that 1110U81 is a potent inhibitor of HCMV DNA replication (50% inhibitory concentration [IC₅₀], 3.6 μM; IC₉₀, 5.6 μM) and also potentiates the effects of ganciclovir (GCV) against HCMV. The IC₉₀ of GCV is reduced from 65 μM when GCV alone is given to 2.8 μM when GCV is combined with 1110U81 at a molar ratio of 1:1.

Original language	English (US)
Pages (from-to)	602-604
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	37
Issue number	3
DOIs	https://doi.org/10.1128/AAC.37.3.602
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir. / Hamzeh, F. M.; Spector, T.; Lietman, P. S.
In: Antimicrobial agents and chemotherapy, Vol. 37, No. 3, 1993, p. 602-604.

Research output: Contribution to journal › Comment/debate › peer-review

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abstract = "We studied the effects of 2-acetylpyridine 5- [(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81 or A1110U), a potent inhibitor of the ribonucleotide reductases encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus, against human cytomegalovirus (HCMV) replication in infected MRC-5 cells. We show that 1110U81 is a potent inhibitor of HCMV DNA replication (50% inhibitory concentration [IC50], 3.6 μM; IC90, 5.6 μM) and also potentiates the effects of ganciclovir (GCV) against HCMV. The IC90 of GCV is reduced from 65 μM when GCV alone is given to 2.8 μM when GCV is combined with 1110U81 at a molar ratio of 1:1.",

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N2 - We studied the effects of 2-acetylpyridine 5- [(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81 or A1110U), a potent inhibitor of the ribonucleotide reductases encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus, against human cytomegalovirus (HCMV) replication in infected MRC-5 cells. We show that 1110U81 is a potent inhibitor of HCMV DNA replication (50% inhibitory concentration [IC50], 3.6 μM; IC90, 5.6 μM) and also potentiates the effects of ganciclovir (GCV) against HCMV. The IC90 of GCV is reduced from 65 μM when GCV alone is given to 2.8 μM when GCV is combined with 1110U81 at a molar ratio of 1:1.

AB - We studied the effects of 2-acetylpyridine 5- [(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81 or A1110U), a potent inhibitor of the ribonucleotide reductases encoded by herpes simplex virus types 1 and 2 and by varicella-zoster virus, against human cytomegalovirus (HCMV) replication in infected MRC-5 cells. We show that 1110U81 is a potent inhibitor of HCMV DNA replication (50% inhibitory concentration [IC50], 3.6 μM; IC90, 5.6 μM) and also potentiates the effects of ganciclovir (GCV) against HCMV. The IC90 of GCV is reduced from 65 μM when GCV alone is given to 2.8 μM when GCV is combined with 1110U81 at a molar ratio of 1:1.

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2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (1110U81) potently inhibits human cytomegalovirus replication and potentiates the antiviral effects of ganciclovir

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