14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

Maria Laura Bertolaccini; Olga Amengual; Laura Andreoli; Tatsuya Atsumi; Cecilia B. Chighizola; Ricardo Forastiero; Philip de Groot; Gabriella Lakos; Marc Lambert; Pierluigi Meroni; Thomas L. Ortel; Michelle Petri; Anisur Rahman; Robert Roubey; Savino Sciascia; Melissa Snyder; Anne E. Tebo; Angela Tincani; Rohan Willis

doi:10.1016/j.autrev.2014.05.001

14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

Maria Laura Bertolaccini, Olga Amengual, Laura Andreoli, Tatsuya Atsumi, Cecilia B. Chighizola, Ricardo Forastiero, Philip de Groot, Gabriella Lakos, Marc Lambert, Pierluigi Meroni, Thomas L. Ortel, Michelle Petri, Anisur Rahman, Robert Roubey, Savino Sciascia, Melissa Snyder, Anne E. Tebo, Angela Tincani, Rohan Willis

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

Abstract

Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).

Original language	English (US)
Pages (from-to)	917-930
Number of pages	14
Journal	Autoimmunity Reviews
Volume	13
Issue number	9
DOIs	https://doi.org/10.1016/j.autrev.2014.05.001
State	Published - 2014
Externally published	Yes

Keywords

ACL
Antiprothrombin antibodies
Domain I
IgA
Lupus anticoagulant
Risk

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.autrev.2014.05.001

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Bertolaccini, M. L., Amengual, O., Andreoli, L., Atsumi, T., Chighizola, C. B., Forastiero, R., de Groot, P., Lakos, G., Lambert, M., Meroni, P., Ortel, T. L., Petri, M., Rahman, A., Roubey, R., Sciascia, S., Snyder, M., Tebo, A. E., Tincani, A., & Willis, R. (2014). 14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends. Autoimmunity Reviews, 13(9), 917-930. https://doi.org/10.1016/j.autrev.2014.05.001

Bertolaccini, ML, Amengual, O, Andreoli, L, Atsumi, T, Chighizola, CB, Forastiero, R, de Groot, P, Lakos, G, Lambert, M, Meroni, P, Ortel, TL, Petri, M, Rahman, A, Roubey, R, Sciascia, S, Snyder, M, Tebo, AE, Tincani, A & Willis, R 2014, '14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends', Autoimmunity Reviews, vol. 13, no. 9, pp. 917-930. https://doi.org/10.1016/j.autrev.2014.05.001

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abstract = "Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the {"}APS Task Force 3-Laboratory Diagnostics and Trends{"} meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).",

keywords = "ACL, Antiprothrombin antibodies, Domain I, IgA, Lupus anticoagulant, Risk",

author = "Bertolaccini, {Maria Laura} and Olga Amengual and Laura Andreoli and Tatsuya Atsumi and Chighizola, {Cecilia B.} and Ricardo Forastiero and {de Groot}, Philip and Gabriella Lakos and Marc Lambert and Pierluigi Meroni and Ortel, {Thomas L.} and Michelle Petri and Anisur Rahman and Robert Roubey and Savino Sciascia and Melissa Snyder and Tebo, {Anne E.} and Angela Tincani and Rohan Willis",

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year = "2014",

doi = "10.1016/j.autrev.2014.05.001",

language = "English (US)",

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AU - Andreoli, Laura

AU - Atsumi, Tatsuya

AU - Chighizola, Cecilia B.

AU - Forastiero, Ricardo

AU - de Groot, Philip

AU - Lakos, Gabriella

AU - Lambert, Marc

AU - Meroni, Pierluigi

AU - Ortel, Thomas L.

AU - Petri, Michelle

AU - Rahman, Anisur

AU - Roubey, Robert

AU - Sciascia, Savino

AU - Snyder, Melissa

AU - Tebo, Anne E.

AU - Tincani, Angela

AU - Willis, Rohan

PY - 2014

Y1 - 2014

N2 - Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).

AB - Current classification criteria for definite Antiphospholipid Syndrome (APS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-β2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, RJ, Brazil).

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KW - Antiprothrombin antibodies

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KW - IgA

KW - Lupus anticoagulant

KW - Risk

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14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

Abstract

Keywords

ASJC Scopus subject areas

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