14-3-3, an integrator of cell mechanics and cytokinesis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


One of the goals of understanding cytokinesis is to uncover the molecular regulation of the cellular mechanical properties that drive cell shape change. Such regulatory pathways are likely to be used at multiple stages of a cell's life, but are highly featured during cell division. Recently, we demonstrated that 14-3-3 (encoded by a single gene in the social amoeba Dictyostelium discoideum) serves to integrate key cytoskeletal components- microtubules, Rac and myosin II-to control cell mechanics and cytokinesis. As 14-3-3 proteins are frequently altered in a variety of human tumors, we extend these observations to suggest possible additional roles for how 14-3-3 proteins may contribute to tumorigenesis.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalSmall GTPases
Issue number3
StatePublished - 2010


  • 14-3-3
  • Bipolar thick filament
  • Cancer
  • Cell mechanics
  • Cortical tension
  • Cytokinesis
  • Microtubules
  • Myosin II
  • Rac
  • Tumor suppressor
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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