1.04 - Microbiota and Estrogen Metabolism

Jennifer Chen, Jacqueline Douglass, Mehran Habibi

Research output: Chapter in Book/Report/Conference proceedingChapter


The gut microbiota-estrogen axis consists of the inhabiting microorganisms in the intestines and the composite β-glucuronidase activity present to convert estrogen and its metabolites to free, circulating active estrogen. Through this interaction, the diversity and makeup of the gut microbiome is a major determinant of an individual's lifetime exposure to estrogen. Potential therapies that target the gut microbiota-estrogen connection represent a novel approach to treat pathologies mediated by hypo- and hyper-estrogenic states.

Original languageEnglish (US)
Title of host publicationComprehensive Gut Microbiota
Number of pages8
ISBN (Electronic)9780128192658
ISBN (Print)9780128220368
StatePublished - Jan 1 2022


  • Breast cancer
  • Dysbiosis
  • Endometrial hyperplasia
  • Estrobolome
  • Estrogen
  • Estrogen metabolism
  • Gut microbiome
  • Menopause
  • Metabolic syndrome
  • PCOS
  • Phytoestrogens
  • β-glucuronidase

ASJC Scopus subject areas

  • General Immunology and Microbiology


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