1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D2 receptor hypersensitivity in the mouse is transient

S. J. Peroutka; L. DeLanney; I. Irwin; P. J. Ison; G. Ricaurte; J. R. Schlegel; J. W. Langston

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D₂ receptor hypersensitivity in the mouse is transient

S. J. Peroutka, L. DeLanney, I. Irwin, P. J. Ison, G. Ricaurte, J. R. Schlegel, J. W. Langston

Research output: Contribution to journal › Article › peer-review

Abstract

Adult C57 B1 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using two dosage regimens. Following a 20 mg/kg/hour x 4 schedule, the number of dopamine D₂ receptors labeled by ³H-spiperone was significantly increased at 2 days following the last injection of MPTP (124 ± 8.0% of control values; p < 0.025). Scatchard analysis revealed an increase in the number of ³H-spiperone binding sites. No significant difference between the control and MPTP treated animals could be detected in ³H-spiperone binding at 4 and 6 days following the short term MPTP treatment. Similarly, a regimen of 30 mg/kg/day x 10 MPTP caused a transient increase in ³H-spiperone binding to dopamine D₂ receptor (1 day: 143 ± 12%, p < 0.01; 10 days: 101 ± 3.7%, p > 0.05). These results suggest that MPTP does not produce permanent supersensitivity of dopamine D₂ reeptors in the mnouse.

Original language	English (US)
Pages (from-to)	163-171
Number of pages	9
Journal	Research communications in chemical pathology and pharmacology
Volume	48
Issue number	2
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pathology and Forensic Medicine
Toxicology
Pharmacology

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title = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D2 receptor hypersensitivity in the mouse is transient",

abstract = "Adult C57 B1 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using two dosage regimens. Following a 20 mg/kg/hour x 4 schedule, the number of dopamine D2 receptors labeled by 3H-spiperone was significantly increased at 2 days following the last injection of MPTP (124 ± 8.0% of control values; p < 0.025). Scatchard analysis revealed an increase in the number of 3H-spiperone binding sites. No significant difference between the control and MPTP treated animals could be detected in 3H-spiperone binding at 4 and 6 days following the short term MPTP treatment. Similarly, a regimen of 30 mg/kg/day x 10 MPTP caused a transient increase in 3H-spiperone binding to dopamine D2 receptor (1 day: 143 ± 12%, p < 0.01; 10 days: 101 ± 3.7%, p > 0.05). These results suggest that MPTP does not produce permanent supersensitivity of dopamine D2 reeptors in the mnouse.",

author = "Peroutka, {S. J.} and L. DeLanney and I. Irwin and Ison, {P. J.} and G. Ricaurte and Schlegel, {J. R.} and Langston, {J. W.}",

year = "1985",

language = "English (US)",

volume = "48",

pages = "163--171",

journal = "Research communications in chemical pathology and pharmacology",

issn = "0034-5164",

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T1 - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D2 receptor hypersensitivity in the mouse is transient

AU - Peroutka, S. J.

AU - DeLanney, L.

AU - Irwin, I.

AU - Ison, P. J.

AU - Ricaurte, G.

AU - Schlegel, J. R.

AU - Langston, J. W.

PY - 1985

Y1 - 1985

N2 - Adult C57 B1 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using two dosage regimens. Following a 20 mg/kg/hour x 4 schedule, the number of dopamine D2 receptors labeled by 3H-spiperone was significantly increased at 2 days following the last injection of MPTP (124 ± 8.0% of control values; p < 0.025). Scatchard analysis revealed an increase in the number of 3H-spiperone binding sites. No significant difference between the control and MPTP treated animals could be detected in 3H-spiperone binding at 4 and 6 days following the short term MPTP treatment. Similarly, a regimen of 30 mg/kg/day x 10 MPTP caused a transient increase in 3H-spiperone binding to dopamine D2 receptor (1 day: 143 ± 12%, p < 0.01; 10 days: 101 ± 3.7%, p > 0.05). These results suggest that MPTP does not produce permanent supersensitivity of dopamine D2 reeptors in the mnouse.

AB - Adult C57 B1 mice were injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using two dosage regimens. Following a 20 mg/kg/hour x 4 schedule, the number of dopamine D2 receptors labeled by 3H-spiperone was significantly increased at 2 days following the last injection of MPTP (124 ± 8.0% of control values; p < 0.025). Scatchard analysis revealed an increase in the number of 3H-spiperone binding sites. No significant difference between the control and MPTP treated animals could be detected in 3H-spiperone binding at 4 and 6 days following the short term MPTP treatment. Similarly, a regimen of 30 mg/kg/day x 10 MPTP caused a transient increase in 3H-spiperone binding to dopamine D2 receptor (1 day: 143 ± 12%, p < 0.01; 10 days: 101 ± 3.7%, p > 0.05). These results suggest that MPTP does not produce permanent supersensitivity of dopamine D2 reeptors in the mnouse.

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SN - 0034-5164

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JO - Research communications in chemical pathology and pharmacology

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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced dopamine D₂ receptor hypersensitivity in the mouse is transient

Abstract

ASJC Scopus subject areas

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