γ-Aminobutyric acid A or C receptor? γ-Aminobutyric acid ρ₁ receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ- aminobutyric acid responses in Xenopus oocytes

Xenopus oocyte expression of the recently cloned γ-aminobutyric acid (GABA)(ρ1) receptor subunit cDNA yields a pharmacologic profile characteristic of the GABA(c) responses described by Johnston [Benzodiazepine/GABA Receptors and Chloride Channels. Receptor Biochemistry and Methodology (R. W. Olsen and J. C. Venter, eds.), Vol. 5. Alan R. Liss, New York, 57-71 (1986)] and the responses to retinal mRNA recently reported in the Xenopus expression system [Proc. Natl. Acad. Sci. USA 88:4318-4322 (1991)]. A rationale for defining GABA (ρ1) as forming a GABA(c) receptor is discussed.