β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man

S. E. Antonarakis; J. A. Phillips; R. L. Mallonee; H. H. Kazazian; E. R. Fearon; P. G. Waber; H. M. Kronenberg; A. Ullrich; D. A. Meyers

doi:10.1073/pnas.80.21.6615

β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man

S. E. Antonarakis, J. A. Phillips, R. L. Mallonee, H. H. Kazazian, E. R. Fearon, P. G. Waber, H. M. Kronenberg, A. Ullrich, D. A. Meyers

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Abstract

Using a parathyroid hormone (PTH) cDNA probe we found a common Pst I polymorphic restriction site 3' to the PTH gene in all ethnic groups examined. Because the PTH, insulin, and β-globin loci have been localized to the short arm of chromosome 11 (11p) we used DNA polymorphisms adjacent to each of these three loci to determine whether they are genetically linked and to determine their order. We found that the PTH and β-globin loci are closely linked (estimated recombination fraction, 0.07; 95% confidence limits, 0.05-0.10; lod score, 4.63; odds favoring linkage, 42,000:1). Furthermore, our findings strongly indicate that the β-globin gene cluster lies between the PTH and insulin loci. Therefore, the gene order on 11p is centromere-PTH-β-globin-insulin.

Original language	English (US)
Pages (from-to)	6615-6619
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	80
Issue number	21 I
DOIs	https://doi.org/10.1073/pnas.80.21.6615
State	Published - 1983
Externally published	Yes

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Antonarakis, S. E., Phillips, J. A., Mallonee, R. L., Kazazian, H. H., Fearon, E. R., Waber, P. G., Kronenberg, H. M., Ullrich, A., & Meyers, D. A. (1983). β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man. Proceedings of the National Academy of Sciences of the United States of America, 80(21 I), 6615-6619. https://doi.org/10.1073/pnas.80.21.6615

Antonarakis, SE, Phillips, JA, Mallonee, RL, Kazazian, HH, Fearon, ER, Waber, PG, Kronenberg, HM, Ullrich, A & Meyers, DA 1983, 'β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, no. 21 I, pp. 6615-6619. https://doi.org/10.1073/pnas.80.21.6615

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title = "β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man",

abstract = "Using a parathyroid hormone (PTH) cDNA probe we found a common Pst I polymorphic restriction site 3' to the PTH gene in all ethnic groups examined. Because the PTH, insulin, and β-globin loci have been localized to the short arm of chromosome 11 (11p) we used DNA polymorphisms adjacent to each of these three loci to determine whether they are genetically linked and to determine their order. We found that the PTH and β-globin loci are closely linked (estimated recombination fraction, 0.07; 95% confidence limits, 0.05-0.10; lod score, 4.63; odds favoring linkage, 42,000:1). Furthermore, our findings strongly indicate that the β-globin gene cluster lies between the PTH and insulin loci. Therefore, the gene order on 11p is centromere-PTH-β-globin-insulin.",

author = "Antonarakis, {S. E.} and Phillips, {J. A.} and Mallonee, {R. L.} and Kazazian, {H. H.} and Fearon, {E. R.} and Waber, {P. G.} and Kronenberg, {H. M.} and A. Ullrich and Meyers, {D. A.}",

year = "1983",

doi = "10.1073/pnas.80.21.6615",

language = "English (US)",

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T1 - β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man

AU - Antonarakis, S. E.

AU - Phillips, J. A.

AU - Mallonee, R. L.

AU - Kazazian, H. H.

AU - Fearon, E. R.

AU - Waber, P. G.

AU - Kronenberg, H. M.

AU - Ullrich, A.

AU - Meyers, D. A.

PY - 1983

Y1 - 1983

N2 - Using a parathyroid hormone (PTH) cDNA probe we found a common Pst I polymorphic restriction site 3' to the PTH gene in all ethnic groups examined. Because the PTH, insulin, and β-globin loci have been localized to the short arm of chromosome 11 (11p) we used DNA polymorphisms adjacent to each of these three loci to determine whether they are genetically linked and to determine their order. We found that the PTH and β-globin loci are closely linked (estimated recombination fraction, 0.07; 95% confidence limits, 0.05-0.10; lod score, 4.63; odds favoring linkage, 42,000:1). Furthermore, our findings strongly indicate that the β-globin gene cluster lies between the PTH and insulin loci. Therefore, the gene order on 11p is centromere-PTH-β-globin-insulin.

AB - Using a parathyroid hormone (PTH) cDNA probe we found a common Pst I polymorphic restriction site 3' to the PTH gene in all ethnic groups examined. Because the PTH, insulin, and β-globin loci have been localized to the short arm of chromosome 11 (11p) we used DNA polymorphisms adjacent to each of these three loci to determine whether they are genetically linked and to determine their order. We found that the PTH and β-globin loci are closely linked (estimated recombination fraction, 0.07; 95% confidence limits, 0.05-0.10; lod score, 4.63; odds favoring linkage, 42,000:1). Furthermore, our findings strongly indicate that the β-globin gene cluster lies between the PTH and insulin loci. Therefore, the gene order on 11p is centromere-PTH-β-globin-insulin.

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β-Globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man

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