Yuejin Wu

2021

Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death

Umapathi, P., Mesubi, O. O., Banerjee, P. S., Abrol, N., Wang, Q., Luczak, E. D., Wu, Y., Granger, J. M., Wei, A. C., Reyes Gaido, O. E., Florea, L., Talbot, C. C., Hart, G. W., Zachara, N. E. & Anderson, M. E., Apr 27 2021, In: Circulation. 143, 17, p. 1687-1703 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms

Mesubi, O. O., Rokita, A. G., Abrol, N., Wu, Y., Chen, B., Wang, Q., Granger, J. M., Tucker-Bartley, A., Luczak, E. D., Murphy, K. R., Umapathi, P., Banerjee, P. S., Boronina, T. N., Cole, R. N., Maier, L. S., Wehrens, X. H., Pomerantz, J. L., Song, L. S., Ahima, R. S., Hart, G. W., & 2 othersZachara, N. E. & Anderson, M. E., Jan 19 2021, In: Journal of Clinical Investigation. 131, 2, e95747.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Pde1 inhibition modulates cav1.2 channel to stimulate cardiomyocyte contraction

Muller, G. K., Song, J., Jani, V., Wu, Y., Liu, T., Jeffreys, W. P. D., O'Rourke, B., Anderson, M. E. & Kass, D. A., Oct 15 2021, In: Circulation research. 129, 9, p. 872-886 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII

Konstantinidis, K., Bezzerides, V. J., Lai, L., Isbell, H. M., Wei, A. C., Wu, Y., Viswanathan, M. C., Blum, I. D., Granger, J. M., Heims-Waldron, D., Zhang, D., Luczak, E. D., Murphy, K. R., Lu, F., Gratz, D. H., Manta, B., Wang, Q., Wang, Q., Kolodkin, A. L., Gladyshev, V. N., & 8 othersHund, T. J., Pu, W. T., Wu, M. N., Cammarato, A., Bianchet, M. A., Shea, M. A., Levine, R. L. & Anderson, M. E., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 4663-4678 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

Luczak, E. D., Wu, Y., Granger, J. M., Joiner, M. L. A., Wilson, N. R., Gupta, A., Umapathi, P., Murphy, K. R., Reyes Gaido, O. E., Sabet, A., Corradini, E., Tseng, W. W., Wang, Y., Heck, A. J. R., Wei, A. C., Weiss, R. G. & Anderson, M. E., Dec 1 2020, In: Nature communications. 11, 1, 4416.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2019

Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIδ oxidation

Wu, Y., Wang, Q., Feng, N., Granger, J. M. & Anderson, M. E., Dec 1 2019, In: Scientific reports. 9, 1, 9291.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2016

A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca²⁺ Clock

Wu, Y., Valdivia, H. H., Wehrens, X. H. T. & Anderson, M. E., Feb 1 2016, In: Circulation: Arrhythmia and Electrophysiology. 9, 2, e003180.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2015

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Rasmussen, T. P., Wu, Y., Joiner, M. L. A., Koval, O. M., Wilson, N. R., Luczak, E. D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., Wagnerd, B. A., Soto, J., McCormick, M. L., Kutschke, W., Weiss, R. M., Yu, L., Boudreau, R. L., Abel, E. D., Zhan, F., Spitz, D. R., & 4 othersBuettner, G. R., Song, L. S., Zingmanb, L. V. & Anderson, M. E., Jul 21 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. 9129-9134 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Scopus citations

The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Y., Rasmussen, T. P., Koval, O. M., Joiner, M. L. A., Hall, D. D., Chen, B., Luczak, E. D., Wang, Q., Rokita, A. G., Wehrens, X. H. T., Song, L. S. & Anderson, M. E., Jan 20 2015, In: Nature communications. 6, 6081.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

2014

BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo

Lai, M. H., Wu, Y., Gao, Z., Anderson, M. E., Dalziel, J. E. & Meredith, A. L., Nov 1 2014, In: American Journal of Physiology - Heart and Circulatory Physiology. 307, 9, p. H1327-H1338

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival

Hall, D. D., Wu, Y., Domann, F. E., Spitz, D. R. & Anderson, M. E., May 6 2014, In: PloS one. 9, 5, e96866.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Sarcolemmal ATP-sensitive potassium channels modulate skeletal muscle function under low-intensity workloads

Zhu, Z., Sierra, A., Burnett, C. M. L., Chen, B., Subbotina, E., Koganti, S. R. K., Gao, Z., Wu, Y., Anderson, M. E., Song, L. S., Goldhamer, D. J., Coetzee, W. A., Hodgson-Zingman, D. M. & Zingman, L. V., Jan 2014, In: Journal of General Physiology. 143, 1, p. 119-134 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2013

Genetic inhibition of Na⁺-Ca²⁺ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate

Gao, Z., Rasmussen, T. P., Li, Y., Kutschke, W., Koval, O. M., Wu, Y., Wu, Y., Hall, D. D., Joiner, M. L. A., Wu, X. Q., Swaminathan, P. D., Purohit, A., Zimmerman, K., Weiss, R. M., Philipson, K. D., Song, L. S., Hund, T. J. & Anderson, M. E., Jan 18 2013, In: Circulation research. 112, 2, p. 309-317 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2011

Catecholamine-independent heart rate increases require Ca ²⁺/calmodulin-dependent protein kinase II

Gao, Z., Singh, M. V., Hall, D. D., Koval, O. M., Luczak, E. D., Joiner, M. L. A., Chen, B., Wu, Y., Chaudhary, A. K., Martins, J. B., Hund, T. J., Mohler, P. J., Song, L. S. & Anderson, M. E., Jun 2011, In: Circulation: Arrhythmia and Electrophysiology. 4, 3, p. 379-387 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2010

Ca_V1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations

Koval, O. M., Guan, X., Wu, Y., Joiner, M. L., Gao, Z., Chen, B., Grumbach, I. M., Luczak, E. D., Colbran, R. J., Song, L. S., Hund, T. J., Mohler, P. J. & Anderson, M. E., Mar 16 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4996-5000 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

I_f and SR Ca²⁺ release both contribute to pacemaker activity in canine sinoatrial node cells

Gao, Z., Chen, B., Joiner, M. L. A., Wu, Y., Guan, X., Koval, O. M., Chaudhary, A. K., Cunha, S. R., Mohler, P. J., Martins, J. B., Song, L. S. & Anderson, M. E., Jul 2010, In: Journal of Molecular and Cellular Cardiology. 49, 1, p. 33-40 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2009

Calmodulin kinase II is required for fight or flight sinoatrial node physiology

Wu, Y., Gao, Z., Chen, B., Koval, O. M., Singh, M. V., Guan, X., Hund, T. J., Kutschke, W., Sarma, S., Grumbach, I. M., Wehrens, X. H. T., Mohler, P. J., Song, L. S. & Anderson, M. E., Apr 7 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 14, p. 5972-5977 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Local control of Ca²⁺-induced Ca²⁺ release in mouse sinoatrial node cells

Chen, B., Wu, Y., Mohler, P. J., Anderson, M. E. & Song, L. S., Nov 2009, In: Journal of Molecular and Cellular Cardiology. 47, 5, p. 706-715 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2008

Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel β subunits

Grueter, C. E., Abiria, S. A., Wu, Y., Anderson, M. E. & Colbran, R. J., Feb 12 2008, In: Biochemistry. 47, 6, p. 1760-1767 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

Le Scouarnec, S., Bhasin, N., Vieyres, C., Hund, T. J., Cunha, S. R., Koval, O., Marionneau, C., Chen, B., Wu, Y., Demolombe, S., Song, L. S., Le Marec, H., Probst, V., Schott, J. J., Anderson, M. E. & Mohler, P. J., Oct 7 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 40, p. 15617-15622 6 p.

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

2006

Death, cardiac dysfunction, and arrhythmias are increased by calmodulin kinase II in calcineurin cardiomyopathy

Khoo, M. S. C., Li, J., Singh, M. V., Yang, Y., Kannankeril, P., Wu, Y., Grueter, C. E., Guan, X., Oddis, C. V., Zhang, R., Mendes, L., Ni, G., Madu, E. C., Yang, J., Bass, M., Gomez, R. J., Wadzinski, B. E., Olson, E. N., Colbran, R. J. & Anderson, M. E., Sep 2006, In: Circulation. 114, 13, p. 1352-1359 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

L-Type Ca²⁺ Channel Facilitation Mediated by Phosphorylation of the β Subunit by CaMKII

Grueter, C. E., Abiria, S. A., Dzhura, I., Wu, Y., Ham, A. J. L., Mohler, P. J., Anderson, M. E. & Colbran, R. J., Sep 1 2006, In: Molecular cell. 23, 5, p. 641-650 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

161 Scopus citations

Suppression of dynamic Ca²⁺ transient responses to pacing in ventricular myocytes from mice with genetic calmodulin kinase II inhibition

Wu, Y., Shintani, A., Grueter, C., Zhang, R., Hou, Y., Yang, J., Kranias, E. G., Colbran, R. J. & Anderson, M. E., Feb 2006, In: Journal of Molecular and Cellular Cardiology. 40, 2, p. 213-223 11 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2005

Atrial fibrillation in KCNE1-null mice

Temple, J., Frias, P., Rottman, J., Yang, T., Wu, Y., Verheijck, E. E., Zhang, W., Siprachanh, C., Kanki, H., Atkinson, J. B., King, P., Anderson, M. E., Kupershmidt, S. & Roden, D. M., Jul 8 2005, In: Circulation research. 97, 1, p. 62-69 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Calmodulin kinase II inhibition protects against structural heart disease

Zhang, R., Khoo, M. S. C., Wu, Y., Yang, Y., Grueter, C. E., Ni, G., Price, E. E., Thiel, W., Guatimosim, S., Song, L. S., Madu, E. C., Shah, A. N., Vishnivetskaya, T. A., Atkinson, J. B., Gurevich, V. V., Salama, G., Lederer, W. J., Colbran, R. J. & Anderson, M. E., Apr 2005, In: Nature medicine. 11, 4, p. 409-417 9 p.

Research output: Contribution to journal › Article › peer-review

444 Scopus citations

2004

Calmodulin kinase is functionally targeted to the action potential plateau for regulation of L-type Ca²⁺ current in rabbit cardiomyocytes

Wu, Y., Kimbrough, J. T., Colbran, R. J. & Anderson, M. E., Jan 1 2004, In: Journal of Physiology. 554, 1, p. 145-155 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2003

C terminus L-type Ca²⁺ channel calmodulin-binding domains are 'auto-agonist' ligands in rabbit ventricular myocytes

Dzhura, I., Wu, Y., Zhang, R., Colbran, R. J., Hamilton, S. L. & Anderson, M. E., Aug 1 2003, In: Journal of Physiology. 550, 3, p. 731-738 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2002

Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy

Wu, Y., Temple, J., Zhang, R., Dzhura, I., Zhang, W., Trimble, R., Roden, D. M., Passier, R., Olson, E. N., Colbran, R. J. & Anderson, M. E., Sep 3 2002, In: Circulation. 106, 10, p. 1288-1293 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

217 Scopus citations

Cytoskeletal disrupting agents prevent calmodulin kinase, IQ domain and voltage-dependent facilitation of L-type Ca²⁺ channels

Dzhura, I., Wu, Y., Colbran, R. J., Corbin, J. D., Balser, J. R. & Anderson, M. E., Dec 1 2002, In: Journal of Physiology. 545, 2, p. 399-406 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Reduced repolarization reserve in ventricular myocytes from female mice

Wu, Y. & Anderson, M. E., Feb 15 2002, In: Cardiovascular research. 53, 3, p. 763-769 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2001

Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca²⁺ current in rabbit ventricular myocytes by a common mechanism

Wu, Y., Dzhura, I., Colbran, R. J. & Anderson, M. E., Sep 15 2001, In: Journal of Physiology. 535, 3, p. 679-687 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Calmodulin kinase is a molecular switch for cardiac excitation-contraction coupling

Wu, Y., Colbran, R. J. & Anderson, M. E., Feb 27 2001, In: Proceedings of the National Academy of Sciences of the United States of America. 98, 5, p. 2877-2881 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2000

Altered L-type Ca²⁺ channel currents in vascular smooth muscle cells from experimental diabetic rats

Wang, R., Wu, Y., Tang, G., Wu, L. & Hanna, S. T., Mar 2000, In: American Journal of Physiology - Heart and Circulatory Physiology. 278, 3 47-3, p. H714-H722

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Ca²⁺-activated non-selective cation current in rabbit ventricular myocytes

Wu, Y. & Anderson, M. E., Jan 1 2000, In: Journal of Physiology. 522, 1, p. 51-57 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels

Dzhura, I., Wu, Y., Colbran, R. J., Balser, J. R. & Anderson, M. E., 2000, In: Nature cell biology. 2, 3, p. 173-177 5 p.

Research output: Contribution to journal › Article › peer-review

297 Scopus citations

Determinants for calmodulin binding on voltage-dependent Ca²⁺ channels

Pate, P., Mochca-Morales, J., Wu, Y., Zhang, J. Z., Rodney, G. G., Serysheva, I. I., Williams, B. Y., Anderson, M. E. & Hamilton, S. L., Dec 15 2000, In: Journal of Biological Chemistry. 275, 50, p. 39786-39792 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

116 Scopus citations

1999

Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current

Wu, Y., Roden, D. M. & Anderson, M. E., Apr 30 1999, In: Circulation research. 84, 8, p. 906-912 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

92 Scopus citations

CaM kinase augments cardiac L-type Ca²⁺ current: A cellular mechanism for long Q-T arrhythmias

Yuejin, W. U., Leigh, B., MacMillan, Blair McNeill, R., Colbran, R. J. & Anderson, M. E., 1999, In: American Journal of Physiology. 276, 6 PART 2, p. H2168-H2178

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

CaM kinase augments cardiac L-type Ca²⁺ current: A cellular mechanism for long Q-T arrhythmias

Wu, Y., MacMillan, L. B., McNeill, R. B., Colbran, R. J. & Anderson, M. E., Jun 1999, In: American Journal of Physiology - Heart and Circulatory Physiology. 276, 6 45-6, p. H2168-H2178

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

1997

Altered L-type Ca2+ channel currents in vascular smooth muscle cells from diabetic rats

Wang, R., Wu, Y. & Wu, L., 1997, In: FASEB Journal. 11, 3, p. A60

Research output: Contribution to journal › Article › peer-review

Yuejin Wu

Research output

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