Research output per year
Research output per year
- 43 results
Search results
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2025
Epitope specificity of antibody-mediated protection induced in mice by the malaria vaccine RTS,S/AS01
Flores-Garcia, Y., Salgado-Jimenez, B., Park, M., Mathis-Torres, S., Locke, E., MacGill, R. S., Moskovitz, R., Wilson, I. A. & Zavala, F., Dec 2025, In: npj Vaccines. 10, 1, 101.Research output: Contribution to journal › Article › peer-review
Open Access -
FcγR binding differentially contributes to protection by two human monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein
Kisalu, N. K., Silva Pereira, L. D., Herman, J. D., Asokan, M., Ernste, K., Merriam, J., Liu, C., DeMouth, M. E., Pegu, A., Lofgren, M., Dillon, M., Bonilla, B., MacVicar, R., Zur, Y., Kiyuka, P., Flores-Garcia, Y., Chakraborty, S., Nikolaeva, D., Ogwang, R. & Flynn, B. & 8 others, , Apr 23 2025, In: Science translational medicine. 17, 795, eadk6745.Research output: Contribution to journal › Article › peer-review
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iDC-targeting PfCSP mRNA vaccine confers superior protection against Plasmodium compared to conventional mRNA
Yanik, S., Venkatesh, V., Gordy, J. T., Alameh, M. G., Meza, J., Li, Y., Glass, E., Flores-Garcia, Y., Tam, Y., Chaiyawong, N., Sarkar, D., Weissman, D., Markham, R. & Srinivasan, P., Dec 2025, In: npj Vaccines. 10, 1, 34.Research output: Contribution to journal › Article › peer-review
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Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein
Dacon, C., Moskovitz, R., Swearingen, K., Da Silva Pereira, L., Flores-Garcia, Y., Aleshnick, M., Kanatani, S., Flynn, B., Molina-Cruz, A., Wollenberg, K., Traver, M., Kirtley, P., Purser, L., Dillon, M., Bonilla, B., Franco, A., Petros, S., Kritzberg, J., Tucker, C. & Paez, G. G. & 27 others, , Jan 3 2025, In: Science (New York, N.Y.). 387, 6729, p. eadr0510Research output: Contribution to journal › Article › peer-review
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Virus-like particle-based vaccines targeting the Anopheles mosquito salivary protein TRIO
Francian, A., Flores-Garcia, Y., Powell, J. R., Petrovsky, N., Zavala, F. & Chackerian, B., Feb 2025, In: mSphere. 10, 2Research output: Contribution to journal › Article › peer-review
Open Access -
2024
A candidate antibody drug for prevention of malaria
Williams, K. L., Guerrero, S., Flores-Garcia, Y., Kim, D., Williamson, K. S., Siska, C., Smidt, P., Jepson, S. Z., Li, K., Dennison, S. M., Mathis-Torres, S., Chen, X., Wille-Reece, U., MacGill, R. S., Walker, M., Jongert, E., King, C. R., Ockenhouse, C., Glanville, J. & Moon, J. E. & 10 others, , Jan 2024, In: Nature medicine. 30, 1, p. 117-129 13 p.Research output: Contribution to journal › Article › peer-review
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Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model
Locke, E., Flores-Garcia, Y., Mayer, B. T., MacGill, R. S., Borate, B., Salgado-Jimenez, B., Gerber, M. W., Mathis-Torres, S., Shapiro, S., King, C. R. & Zavala, F., Dec 2024, In: npj Vaccines. 9, 1, 29.Research output: Contribution to journal › Article › peer-review
Open Access -
Hemozoin-induced IFN-γ production mediates innate immune protection against sporozoite infection
Franco, A., Flores-Garcia, Y., Venezia, J., Daoud, A., Scott, A. L., Zavala, F. & Sullivan, D. J., Jul 1 2024, In: Microbes and Infection. 26, 5-6, 105343.Research output: Contribution to journal › Article › peer-review
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Mosquito salivary apyrase regulates blood meal hemostasis and facilitates malaria parasite transmission
Pala, Z. R., Alves e Silva, T. L., Minai, M., Crews, B., Patino-Martinez, E., Carmona-Rivera, C., Valenzuela Leon, P. C., Martin-Martin, I., Flores-Garcia, Y., Cachau, R. E., Muslinkina, L., Gittis, A. G., Srivastava, N., Garboczi, D. N., Alves, D. A., Kaplan, M. J., Fischer, E., Calvo, E. & Vega-Rodriguez, J., Dec 2024, In: Nature communications. 15, 1, 8194.Research output: Contribution to journal › Article › peer-review
Open Access -
ProC6C, a novel multi-stage malaria vaccine, elicits functional antibodies against the minor and central repeats of the Circumsporozoite Protein in human adults
Plieskatt, J., Ofori, E. A., Naghizadeh, M., Miura, K., Flores-Garcia, Y., Borbye-Lorenzen, N., Tiono, A. B., Skogstrand, K., Sagara, I., Zavala, F. & Theisen, M., 2024, In: Frontiers in immunology. 15, 1481829.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection
Martin, G. M., Torres, J. L., Pholcharee, T., Oyen, D., Flores-Garcia, Y., Gibson, G., Moskovitz, R., Beutler, N., Jung, D. D., Copps, J., Lee, W. H., Gonzalez-Paez, G., Emerling, D., MacGill, R. S., Locke, E., King, C. R., Zavala, F., Wilson, I. A. & Ward, A. B., Dec 2023, In: Nature communications. 14, 1, 4546.Research output: Contribution to journal › Article › peer-review
Open Access -
Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
Aguirre-Botero, M. C., Wang, L. T., Formaglio, P., Aliprandini, E., Thiberge, J. M., Schön, A., Flores-Garcia, Y., Mathis-Torres, S., Flynn, B. J., da Silva Pereira, L., Le Duff, Y., Hurley, M., Nacer, A., Bowyer, P. W., Zavala, F., Idris, A. H., Francica, J. R., Seder, R. A. & Amino, R., Jul 25 2023, In: Cell Reports. 42, 7, 112681.Research output: Contribution to journal › Article › peer-review
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Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein
Thai, E., Murugan, R., Binter, Š., Burn Aschner, C., Prieto, K., Kassardjian, A., Obraztsova, A. S., Kang, R. W., Flores-Garcia, Y., Mathis-Torres, S., Li, K., Horn, G. Q., Huntwork, R. H. C., Bolscher, J. M., de Bruijni, M. H. C., Sauerwein, R., Dennison, S. M., Tomaras, G. D., Zavala, F. & Kellam, P. & 2 others, , Nov 28 2023, In: Cell Reports. 42, 11, 113330.Research output: Contribution to journal › Article › peer-review
Open Access -
Plasmodium berghei Purified Hemozoin Associated with DNA Strongly Inhibits P. berghei Liver-Stage Development in BALB/c Mice after Intravenous Inoculation
Franco, A., Flores-Garcia, Y., Zavala, F. & Sullivan, D. J., Jan 2023, In: Infection and immunity. 91, 1Research output: Contribution to journal › Article › peer-review
Open Access -
2022
A novel CSP C-Terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum
Beutler, N., Pholcharee, T., Oyen, D., Flores-Garcia, Y., MacGill, R. S., Garcia, E., Calla, J., Parren, M., Yang, L., Volkmuth, W., Locke, E., Regules, J. A., Dutta, S., Emerling, D., Early, A. M., Neafsey, D. E., Winzeler, E., Richter King, C., Zavala, F. & Burton, D. R. & 2 others, , Mar 2022, In: PLoS pathogens. 18, 3, e1010409.Research output: Contribution to journal › Article › peer-review
Open Access -
A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model
Jelínková, L., Flores-Garcia, Y., Shapiro, S., Roberts, B. T., Petrovsky, N., Zavala, F. & Chackerian, B., Dec 2022, In: npj Vaccines. 7, 1, 34.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model
Tursi, N. J., Reeder, S. M., Flores-Garcia, Y., Bah, M. A., Mathis-Torres, S., Salgado-Jimenez, B., Esquivel, R., Xu, Z., Chu, J. D., Humeau, L., Patel, A., Zavala, F. & Weiner, D. B., Dec 2022, In: Scientific reports. 12, 1, 14313.Research output: Contribution to journal › Article › peer-review
Open Access -
High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire
Kucharska, I., Binter, Š., Murugan, R., Scally, S. W., Ludwig, J., Prieto, K., Thai, E., Costa, G., Li, K., Horn, G. Q., Flores-Garcia, Y., Bosch, A., Sicard, T., Rubinstein, J. L., Zavala, F., Moses Dennison, S., Tomaras, G. D., Levashina, E. A., Kellam, P. & Wardemann, H. & 1 others, , Nov 2022, In: PLoS pathogens. 18, 11, e1010999.Research output: Contribution to journal › Article › peer-review
Open Access -
The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria
Wang, L. T., Hurlburt, N. K., Schön, A., Flynn, B. J., Flores-Garcia, Y., Pereira, L. S., Kiyuka, P. K., Dillon, M., Bonilla, B., Zavala, F., Idris, A. H., Francica, J. R., Pancera, M. & Seder, R. A., Feb 15 2022, In: Cell Reports. 38, 7, 110367.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection
Sahu, T., Gehrke, E. J., Flores-Garcia, Y., Mlambo, G., Romano, J. D. & Coppens, I., Dec 2021, In: npj Vaccines. 6, 1, 98.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention
Kisalu, N. K., Pereira, L. D., Ernste, K., Flores-Garcia, Y., Idris, A. H., Asokan, M., Dillon, M., MacDonald, S., Shi, W., Chen, X., Pegu, A., Schön, A., Zavala, F., Balazs, A. B., Francica, J. R. & Seder, R. A., Feb 8 2021, In: JCI Insight. 6, 3, e143958.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
Pholcharee, T., Oyen, D., Flores-Garcia, Y., Gonzalez-Paez, G., Han, Z., Williams, K. L., Volkmuth, W., Emerling, D., Locke, E., Richter King, C., Zavala, F. & Wilson, I. A., Dec 1 2021, In: Nature communications. 12, 1, 1063.Research output: Contribution to journal › Article › peer-review
Open Access -
The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo
Flores-Garcia, Y., Wang, L. T., Park, M., Asady, B., Idris, A. H., Kisalu, N. K., Muñoz, C., Pereira, L. S., Francica, J. R., Seder, R. A. & Zavala, F., Nov 2021, In: PLoS pathogens. 17, 11, e1010042.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity
Thai, E., Costa, G., Weyrich, A., Murugan, R., Oyen, D., Flores-Garcia, Y., Prieto, K., Bosch, A., Valleriani, A., Wu, N. C., Pholcharee, T., Scally, S. W., Wilson, I. A., Wardemann, H., Julien, J. P. & Levashina, E. A., Aug 2020, In: Journal of Experimental Medicine. 217, 11, e20200061.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver
Wang, L. T., Pereira, L. S., Flores-Garcia, Y., O'Connor, J., Flynn, B. J., Schön, A., Hurlburt, N. K., Dillon, M., Yang, A. S. P., Fabra-García, A., Idris, A. H., Mayer, B. T., Gerber, M. W., Gottardo, R., Mason, R. D., Cavett, N., Ballard, R. B., Kisalu, N. K., Molina-Cruz, A. & Nelson, J. & 11 others, , Oct 13 2020, In: Immunity. 53, 4, p. 733-744.e8Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
A Proinflammatory Immune Response Might Determine Toxoplasma gondii Vertical Transmission and Severity of Clinical Features in Congenitally Infected Newborns
Gómez-Chávez, F., Cañedo-Solares, I., Ortiz-Alegría, L. B., Flores-García, Y., Figueroa-Damián, R., Luna-Pastén, H., Gómez-Toscano, V., López-Candiani, C., Arce-Estrada, G. E., Bonilla-Ríos, C. A., Mora-González, J. C., García-Ruiz, R. & Correa, D., Mar 13 2020, In: Frontiers in immunology. 11, 390.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein
Raghunandan, R., Mayer, B. T., Flores-Garcia, Y., Gerber, M. W., Gottardo, R., Jhun, H., Herrera, S. M., Perez-Ramos, D. W., Locke, E., King, C. R. & Zavala, F., Mar 17 2020, In: Malaria journal. 19, 1, 113.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein
Pholcharee, T., Oyen, D., Torres, J. L., Flores-Garcia, Y., Martin, G. M., González-Páez, G. E., Emerling, D., Volkmuth, W., Locke, E., King, C. R., Zavala, F., Ward, A. B. & Wilson, I. A., Feb 14 2020, In: Journal of molecular biology. 432, 4, p. 1048-1063 16 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., Linnekin, T., Kulkarni, V., Lu, R., Slein, M. D., Luedemann, C., Marquette, M., March, S., Weiner, J., Gregory, S. & Coccia, M. & 12 others, , Jul 22 2020, In: Science translational medicine. 12, 553, eabb4757.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein
Oyen, D., Torres, J. L., Aoto, P. C., Flores-Garcia, Y., Binter, Š., Pholcharee, T., Carroll, S., Reponen, S., Wash, R., Liang, Q., Lemiale, F., Locke, E., Bradley, A., Richter King, C., Emerling, D., Kellam, P., Zavala, F., Ward, A. B. & Wilson, I. A., 2020, In: PLoS pathogens. 16, 3, e1008373.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Vorinostat as potential antiparasitic drug
Herrera-Martínez, M., Orozco-Samperio, E., Montanõ, S., Ariza-Ortega, J. A., Flores-Garciá, Y. & López-Contreras, L., 2020, In: European review for medical and pharmacological sciences. 24, 13, p. 7412-7419 8 p.Research output: Contribution to journal › Article › peer-review
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2019
Irradiated sporozoite vaccination induces sex-specific immune responses and protection against malaria in mice
vom Steeg, L. G., Flores-Garcia, Y., Zavala, F. & Klein, S. L., Jul 26 2019, In: Vaccine. 37, 32, p. 4468-4476 9 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Maternal immune response during pregnancy and vertical transmission in human toxoplasmosis
Gómez-Chávez, F., Cañedo-Solares, I., Ortiz-Alegría, L. B., Flores-García, Y., Luna-Pastén, H., Figueroa-Damián, R., Mora-González, J. C. & Correa, D., 2019, In: Frontiers in immunology. 10, FEB, 285.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages
Flores-Garcia, Y., Herrera, S. M., Jhun, H., Pérez-Ramos, D. W., King, C. R., Locke, E., Raghunandan, R. & Zavala, F., Dec 18 2019, In: Malaria journal. 18, 1, 426.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2018
A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A. & Monroe, A. & 18 others, , May 1 2018, In: Nature medicine. 24, 4, p. 408-416 9 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
Antibody-mediated protection against plasmodium sporozoites begins at the dermal inoculation site
Flores-Garcia, Y., Nasir, G., Hopp, C. S., Munoz, C., Balaban, A. E., Zavala, F. & Sinnis, P., Nov 1 2018, In: mBio. 9, 6, e02194-18.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
What do anti-Toxoplasma gondii IgA and IgG subclasses in human saliva indicate?
Cañedo-Solares, I., Gómez-Chávez, F., Luna-Pastén, H., Ortiz-Alegría, L. B., Flores-García, Y., Figueroa-Damián, R., Macedo-Romero, C. A. & Correa, D., May 2018, In: Parasite Immunology. 40, 5, e12526.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
2017
Development of a novel virus-like particle vaccine platform that mimics the immature form of alphavirus
Urakami, A., Sakurai, A., Ishikawa, M., Yap, M. L., Flores-Garcia, Y., Haseda, Y., Aoshi, T., Zavala, F. P., Rossmann, M. G., Kuno, S., Ueno, R. & Akahata, W., Jul 2017, In: Clinical and Vaccine Immunology. 24, 7, e00090-17.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
Oyen, D., Torres, J. L., Wille-Reece, U., Ockenhouse, C. F., Emerling, D., Glanville, J., Volkmuth, W., Flores-Garcia, Y., Zavala, F., Ward, A. B., Richter King, C. & Wilson, I. A., Nov 28 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. E10438-E10445Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
The Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites as a candidate for preerythrocytic and transmission-blocking vaccines
Espinosa, D. A., Vega-Rodriguez, J., Flores-Garcia, Y., Noe, A. R., Muñoz, C., Coleman, R., Bruck, T., Haney, K., Stevens, A., Retallack, D., Allen, J., Vedvick, T. S., Fox, C. B., Reed, S. G., Howard, R. F., Salman, A. M., Janse, C. J., Khan, S. M., Zavala, F. & Gutierrez, G. M., 2017, In: Infection and immunity. 85, 2, e00498-16.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
2013
CD4 + CD25 + FOXP3 + treg cells induced by rSSP4 derived from T. cruzi amastigotes increase parasitemia in an experimental chagas disease model
Flores-García, Y., Rosales-Encina, J. L., Rosales-García, V. H., Satoskar, A. R. & Talamás-Rohana, P., 2013, In: BioMed research international. 2013, 632436.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Src and PI3 K inhibitors affect the virulence factors of Entamoeba histolytica
López-Contreras, L., Hernández-Ramírez, V. I., Flores-García, Y., Chávez-Munguía, B. & Talamás-Rohana, P., Feb 2013, In: Parasitology. 140, 2, p. 202-209 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
2011
IL-10-IFN-γ double producers CD4+ T cells are induced by immunization with an amastigote stage specific derived recombinant protein of Trypanosoma cruzi
Flores-García, Y., Rosales-Encina, J. L., Satoskar, A. R. & Talamás-Rohana, P., 2011, In: International Journal of Biological Sciences. 7, 7, p. 1093-1100 8 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations