Yevel Flores Garcia

2024

Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

Locke, E., Flores-Garcia, Y., Mayer, B. T., MacGill, R. S., Borate, B., Salgado-Jimenez, B., Gerber, M. W., Mathis-Torres, S., Shapiro, S., King, C. R. & Zavala, F., Dec 2024, In: npj Vaccines. 9, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection

Martin, G. M., Torres, J. L., Pholcharee, T., Oyen, D., Flores-Garcia, Y., Gibson, G., Moskovitz, R., Beutler, N., Jung, D. D., Copps, J., Lee, W. H., Gonzalez-Paez, G., Emerling, D., MacGill, R. S., Locke, E., King, C. R., Zavala, F., Wilson, I. A. & Ward, A. B., Dec 2023, In: Nature communications. 14, 1, 4546.

Research output: Contribution to journal › Article › peer-review

Open Access

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

Aguirre-Botero, M. C., Wang, L. T., Formaglio, P., Aliprandini, E., Thiberge, J. M., Schön, A., Flores-Garcia, Y., Mathis-Torres, S., Flynn, B. J., da Silva Pereira, L., Le Duff, Y., Hurley, M., Nacer, A., Bowyer, P. W., Zavala, F., Idris, A. H., Francica, J. R., Seder, R. A. & Amino, R., Jul 25 2023, In: Cell Reports. 42, 7, 112681.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein

Thai, E., Murugan, R., Binter, Š., Burn Aschner, C., Prieto, K., Kassardjian, A., Obraztsova, A. S., Kang, R. W., Flores-Garcia, Y., Mathis-Torres, S., Li, K., Horn, G. Q., Huntwork, R. H. C., Bolscher, J. M., de Bruijni, M. H. C., Sauerwein, R., Dennison, S. M., Tomaras, G. D., Zavala, F., Kellam, P., & 2 othersWardemann, H. & Julien, J. P., Nov 28 2023, In: Cell Reports. 42, 11, 113330.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasmodium berghei Purified Hemozoin Associated with DNA Strongly Inhibits P. berghei Liver-Stage Development in BALB/c Mice after Intravenous Inoculation

Franco, A., Flores-Garcia, Y., Zavala, F. & Sullivan, D. J., Jan 2023, In: Infection and immunity. 91, 1

Research output: Contribution to journal › Article › peer-review

2022

A novel CSP C-Terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum

Beutler, N., Pholcharee, T., Oyen, D., Flores-Garcia, Y., MacGill, R. S., Garcia, E., Calla, J., Parren, M., Yang, L., Volkmuth, W., Locke, E., Regules, J. A., Dutta, S., Emerling, D., Early, A. M., Neafsey, D. E., Winzeler, E., Richter King, C., Zavala, F., Burton, D. R., & 2 othersWilson, I. A. & Rogers, T. F., Mar 2022, In: PLoS pathogens. 18, 3, e1010409.

Research output: Contribution to journal › Article › peer-review

Open Access

A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

Jelínková, L., Flores-Garcia, Y., Shapiro, S., Roberts, B. T., Petrovsky, N., Zavala, F. & Chackerian, B., Dec 2022, In: npj Vaccines. 7, 1, 34.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

Tursi, N. J., Reeder, S. M., Flores-Garcia, Y., Bah, M. A., Mathis-Torres, S., Salgado-Jimenez, B., Esquivel, R., Xu, Z., Chu, J. D., Humeau, L., Patel, A., Zavala, F. & Weiner, D. B., Dec 2022, In: Scientific reports. 12, 1, 14313.

Research output: Contribution to journal › Article › peer-review

Open Access

High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire

Kucharska, I., Binter, Š., Murugan, R., Scally, S. W., Ludwig, J., Prieto, K., Thai, E., Costa, G., Li, K., Horn, G. Q., Flores-Garcia, Y., Bosch, A., Sicard, T., Rubinstein, J. L., Zavala, F., Moses Dennison, S., Tomaras, G. D., Levashina, E. A., Kellam, P., Wardemann, H., & 1 othersJulien, J. P., Nov 2022, In: PLoS pathogens. 18, 11, e1010999.

Research output: Contribution to journal › Article › peer-review

Open Access

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

Wang, L. T., Hurlburt, N. K., Schön, A., Flynn, B. J., Flores-Garcia, Y., Pereira, L. S., Kiyuka, P. K., Dillon, M., Bonilla, B., Zavala, F., Idris, A. H., Francica, J. R., Pancera, M. & Seder, R. A., Feb 15 2022, In: Cell Reports. 38, 7, 110367.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Chemoprophylaxis vaccination with a Plasmodium liver stage autophagy mutant affords enhanced and long-lasting protection

Sahu, T., Gehrke, E. J., Flores-Garcia, Y., Mlambo, G., Romano, J. D. & Coppens, I., Dec 2021, In: npj Vaccines. 6, 1, 98.

Research output: Contribution to journal › Article › peer-review

Open Access

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

Kisalu, N. K., Pereira, L. D., Ernste, K., Flores-Garcia, Y., Idris, A. H., Asokan, M., Dillon, M., MacDonald, S., Shi, W., Chen, X., Pegu, A., Schön, A., Zavala, F., Balazs, A. B., Francica, J. R. & Seder, R. A., Feb 8 2021, In: JCI Insight. 6, 3, e143958.

Research output: Contribution to journal › Article › peer-review

Open Access

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

Pholcharee, T., Oyen, D., Flores-Garcia, Y., Gonzalez-Paez, G., Han, Z., Williams, K. L., Volkmuth, W., Emerling, D., Locke, E., Richter King, C., Zavala, F. & Wilson, I. A., Dec 1 2021, In: Nature communications. 12, 1, 1063.

Research output: Contribution to journal › Article › peer-review

Open Access

The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo

Flores-Garcia, Y., Wang, L. T., Park, M., Asady, B., Idris, A. H., Kisalu, N. K., Muñoz, C., Pereira, L. S., Francica, J. R., Seder, R. A. & Zavala, F., Nov 2021, In: PLoS pathogens. 17, 11, e1010042.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity

Thai, E., Costa, G., Weyrich, A., Murugan, R., Oyen, D., Flores-Garcia, Y., Prieto, K., Bosch, A., Valleriani, A., Wu, N. C., Pholcharee, T., Scally, S. W., Wilson, I. A., Wardemann, H., Julien, J. P. & Levashina, E. A., Aug 2020, In: Journal of Experimental Medicine. 217, 11, e20200061.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver

Wang, L. T., Pereira, L. S., Flores-Garcia, Y., O'Connor, J., Flynn, B. J., Schön, A., Hurlburt, N. K., Dillon, M., Yang, A. S. P., Fabra-García, A., Idris, A. H., Mayer, B. T., Gerber, M. W., Gottardo, R., Mason, R. D., Cavett, N., Ballard, R. B., Kisalu, N. K., Molina-Cruz, A., Nelson, J., & 11 othersVistein, R., Barillas-Mury, C., Amino, R., Baker, D., King, N. P., Sauerwein, R. W., Pancera, M., Cockburn, I. A., Zavala, F., Francica, J. R. & Seder, R. A., Oct 13 2020, In: Immunity. 53, 4, p. 733-744.e8

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

A Proinflammatory Immune Response Might Determine Toxoplasma gondii Vertical Transmission and Severity of Clinical Features in Congenitally Infected Newborns

Gómez-Chávez, F., Cañedo-Solares, I., Ortiz-Alegría, L. B., Flores-García, Y., Figueroa-Damián, R., Luna-Pastén, H., Gómez-Toscano, V., López-Candiani, C., Arce-Estrada, G. E., Bonilla-Ríos, C. A., Mora-González, J. C., García-Ruiz, R. & Correa, D., Mar 13 2020, In: Frontiers in immunology. 11, 390.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein

Raghunandan, R., Mayer, B. T., Flores-Garcia, Y., Gerber, M. W., Gottardo, R., Jhun, H., Herrera, S. M., Perez-Ramos, D. W., Locke, E., King, C. R. & Zavala, F., Mar 17 2020, In: Malaria journal. 19, 1, 113.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Diverse Antibody Responses to Conserved Structural Motifs in Plasmodium falciparum Circumsporozoite Protein

Pholcharee, T., Oyen, D., Torres, J. L., Flores-Garcia, Y., Martin, G. M., González-Páez, G. E., Emerling, D., Volkmuth, W., Locke, E., King, C. R., Zavala, F., Ward, A. B. & Wilson, I. A., Feb 14 2020, In: Journal of molecular biology. 432, 4, p. 1048-1063 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., Linnekin, T., Kulkarni, V., Lu, R., Slein, M. D., Luedemann, C., Marquette, M., March, S., Weiner, J., Gregory, S., Coccia, M., & 12 othersFlores-Garcia, Y., Zavala, F., Ackerman, M. E., Bergmann-Leitner, E., Hendriks, J., Sadoff, J., Dutta, S., Bhatia, S. N., Lauffenburger, D. A., Jongert, E., Wille-Reece, U. & Alter, G., Jul 22 2020, In: Science translational medicine. 12, 553, eabb4757.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein

Oyen, D., Torres, J. L., Aoto, P. C., Flores-Garcia, Y., Binter, Š., Pholcharee, T., Carroll, S., Reponen, S., Wash, R., Liang, Q., Lemiale, F., Locke, E., Bradley, A., Richter King, C., Emerling, D., Kellam, P., Zavala, F., Ward, A. B. & Wilson, I. A., 2020, In: PLoS pathogens. 16, 3, e1008373.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Vorinostat as potential antiparasitic drug

Herrera-Martínez, M., Orozco-Samperio, E., Montanõ, S., Ariza-Ortega, J. A., Flores-Garciá, Y. & López-Contreras, L., 2020, In: European review for medical and pharmacological sciences. 24, 13, p. 7412-7419 8 p.

Research output: Contribution to journal › Article › peer-review

2019

Irradiated sporozoite vaccination induces sex-specific immune responses and protection against malaria in mice

vom Steeg, L. G., Flores-Garcia, Y., Zavala, F. & Klein, S. L., Jul 26 2019, In: Vaccine. 37, 32, p. 4468-4476 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Maternal immune response during pregnancy and vertical transmission in human toxoplasmosis

Gómez-Chávez, F., Cañedo-Solares, I., Ortiz-Alegría, L. B., Flores-García, Y., Luna-Pastén, H., Figueroa-Damián, R., Mora-González, J. C. & Correa, D., 2019, In: Frontiers in immunology. 10, FEB, 285.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Optimization of an in vivo model to study immunity to Plasmodium falciparum pre-erythrocytic stages

Flores-Garcia, Y., Herrera, S. M., Jhun, H., Pérez-Ramos, D. W., King, C. R., Locke, E., Raghunandan, R. & Zavala, F., Dec 18 2019, In: Malaria journal. 18, 1, 426.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2018

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A., & 18 othersBonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G. Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F., Pancera, M. & Seder, R. A., May 1 2018, In: Nature medicine. 24, 4, p. 408-416 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Antibody-mediated protection against plasmodium sporozoites begins at the dermal inoculation site

Flores-Garcia, Y., Nasir, G., Hopp, C. S., Munoz, C., Balaban, A. E., Zavala, F. & Sinnis, P., Nov 1 2018, In: mBio. 9, 6, e02194-18.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

What do anti-Toxoplasma gondii IgA and IgG subclasses in human saliva indicate?

Cañedo-Solares, I., Gómez-Chávez, F., Luna-Pastén, H., Ortiz-Alegría, L. B., Flores-García, Y., Figueroa-Damián, R., Macedo-Romero, C. A. & Correa, D., May 2018, In: Parasite Immunology. 40, 5, e12526.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2017

Development of a novel virus-like particle vaccine platform that mimics the immature form of alphavirus

Urakami, A., Sakurai, A., Ishikawa, M., Yap, M. L., Flores-Garcia, Y., Haseda, Y., Aoshi, T., Zavala, F. P., Rossmann, M. G., Kuno, S., Ueno, R. & Akahata, W., Jul 2017, In: Clinical and Vaccine Immunology. 24, 7, e00090-17.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein

Oyen, D., Torres, J. L., Wille-Reece, U., Ockenhouse, C. F., Emerling, D., Glanville, J., Volkmuth, W., Flores-Garcia, Y., Zavala, F., Ward, A. B., Richter King, C. & Wilson, I. A., Nov 28 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 48, p. E10438-E10445

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

The Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites as a candidate for preerythrocytic and transmission-blocking vaccines

Espinosa, D. A., Vega-Rodriguez, J., Flores-Garcia, Y., Noe, A. R., Muñoz, C., Coleman, R., Bruck, T., Haney, K., Stevens, A., Retallack, D., Allen, J., Vedvick, T. S., Fox, C. B., Reed, S. G., Howard, R. F., Salman, A. M., Janse, C. J., Khan, S. M., Zavala, F. & Gutierrez, G. M., 2017, In: Infection and immunity. 85, 2, e00498-16.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2013

CD4 + CD25 + FOXP3 + treg cells induced by rSSP4 derived from T. cruzi amastigotes increase parasitemia in an experimental chagas disease model

Flores-García, Y., Rosales-Encina, J. L., Rosales-García, V. H., Satoskar, A. R. & Talamás-Rohana, P., 2013, In: BioMed research international. 2013, 632436.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Src and PI3 K inhibitors affect the virulence factors of Entamoeba histolytica

López-Contreras, L., Hernández-Ramírez, V. I., Flores-García, Y., Chávez-Munguía, B. & Talamás-Rohana, P., Feb 2013, In: Parasitology. 140, 2, p. 202-209 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2011

IL-10-IFN-γ double producers CD4+ T cells are induced by immunization with an amastigote stage specific derived recombinant protein of Trypanosoma cruzi

Flores-García, Y., Rosales-Encina, J. L., Satoskar, A. R. & Talamás-Rohana, P., 2011, In: International Journal of Biological Sciences. 7, 7, p. 1093-1100 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Yevel Flores Garcia

Research output

Search results