Xitiz Chamling

2024

A Novel Approach to Increase Glial Cell Populations in Brain Microphysiological Systems

Morales Pantoja, I. E., Ding, L., Leite, P. E. C., Marques, S. A., Romero, J. C., Alam El Din, D. M., Zack, D. J., Chamling, X. & Smirnova, L., Aug 2024, In: Advanced Biology. 8, 8, 2300198.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells

Li, W., Berlinicke, C., Huang, Y., Giera, S., McGrath, A. G., Fang, W., Chen, C., Takaesu, F., Chang, X., Duan, Y., Kumar, D., Chang, C., Mao, H. Q., Sheng, G., Dodge, J. C., Ji, H., Madden, S., Zack, D. J. & Chamling, X., Mar 17 2023, In: iScience. 26, 3, 106156.

Research output: Contribution to journal › Article › peer-review

Open Access

Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy

Boal, A. M., McGrady, N. R., Chamling, X., Kagitapalli, B. S., Zack, D. J., Calkins, D. J. & Risner, M. L., Apr 2023, In: Translational Vision Science and Technology. 12, 4, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

Neutral sphingomyelinase inhibition promotes local and network degeneration in vitro and in vivo

Risner, M. L., Ribeiro, M., McGrady, N. R., Kagitapalli, B. S., Chamling, X., Zack, D. J. & Calkins, D. J., Dec 2023, In: Cell Communication and Signaling. 21, 1, 305.

Research output: Contribution to journal › Article › peer-review

Open Access

Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system

Romero, J. C., Berlinicke, C., Chow, S., Duan, Y., Wang, Y., Chamling, X. & Smirnova, L., Jan 19 2023, In: Frontiers in Cellular Neuroscience. 16, 1094291.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Ex Vivo Integration of Human Stem Retinal Ganglion Cells into the Mouse Retina

Croteau, L. P., Risner, M. L., Wareham, L. K., McGrady, N. R., Chamling, X., Zack, D. J. & Calkins, D. J., Oct 2022, In: Cells. 11, 20, 3241.

Research output: Contribution to journal › Article › peer-review

Open Access

Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production

Chu, H. S., Peterson, C., Chamling, X., Berlinicke, C., Zack, D., Jun, A. S. & Foster, J., Jul 2022, In: Investigative Ophthalmology and Visual Science. 63, 8, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Smith, M. D., Chamling, X., Gill, A. J., Martinez, H., Li, W., Fitzgerald, K. C., Sotirchos, E. S., Moroziewicz, D., Bauer, L., Paull, D., Gharagozloo, M., Bhargava, P., Zack, D. J., Fossati, V. & Calabresi, P. A., May 6 2022, In: Frontiers in Molecular Neuroscience. 15, 874299.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes

Yazdankhah, M., Ghosh, S., Shang, P., Stepicheva, N., Hose, S., Liu, H., Chamling, X., Tian, S., Sullivan, M. L. G., Calderon, M. J., Fitting, C. S., Weiss, J., Jayagopal, A., Handa, J. T., Sahel, J. A., Zigler, J. S., Kinchington, P. R., Zack, D. J. & Sinha, D., 2021, In: Autophagy. 17, 10, p. 3140-3159 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intrinsic morphologic and physiologic development of human derived retinal ganglion cells in vitro

Risner, M. L., Pasini, S., Chamling, X., McGrady, N. R., Goldberg, J. L., Zack, D. J. & Calkins, D. J., Aug 2021, In: Translational Vision Science and Technology. 10, 10, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells

Chamling, X., Kallman, A., Fang, W., Berlinicke, C. A., Mertz, J. L., Devkota, P., Pantoja, I. E. M., Smith, M. D., Ji, Z., Chang, C., Kaushik, A., Chen, L., Whartenby, K. A., Calabresi, P. A., Mao, H. Q., Ji, H., Wang, T. H. & Zack, D. J., Dec 1 2021, In: Nature communications. 12, 1, 652.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2020

TNFα-mediated priming of mesenchymal stem cells enhances their neuroprotective effect on retinal ganglion cells

Mead, B., Chamling, X., Zack, D. J., Ahmed, Z. & Tomarev, S., Feb 2020, In: Investigative Ophthalmology and Visual Science. 61, 2, 6.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2019

Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines

Capowski, E. E., Samimi, K., Mayerl, S. J., Phillips, M. J., Pinilla, I., Howden, S. E., Saha, J., Jansen, A. D., Edwards, K. L., Jager, L. D., Barlow, K., Valiauga, R., Erlichman, Z., Hagstrom, A., Sinha, D., Sluch, V. M., Chamling, X., Zack, D. J., Skala, M. C. & Gamm, D. M., Jan 1 2019, In: Development (Cambridge). 146, 1, dev171686.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

2018

Data descriptor: Single cell RNA sequencing of stem cell-derived retinal ganglion cells

Daniszewski, M., Senabouth, A., Nguyen, Q. H., Crombie, D. E., Lukowski, S. W., Kulkarni, T., Sluch, V. M., Jabbari, J. S., Chamling, X., Zack, D. J., Pébay, A., Powell, J. E. & Hewitt, A. W., Feb 13 2018, In: Scientific Data. 5, 180013.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Highly efficient scarless knock-in of reporter genes into human and mouse pluripotent stem cells via transient antibiotic selection

Sluch, V. M., Chamling, X., Wenger, C., Duan, Y., Rice, D. S. & Zack, D. J., Nov 2018, In: PloS one. 13, 11, e0201683.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Single cell RNA sequencing of stem cell-derived retinal ganglion cells

Daniszewski, M., Senabouth, A., Nguyen, Q. H., Crombie, D. E., Lukowski, S. W., Kulkarni, T., Sluch, V. M., Jabbari, J. S., Chamling, X., Zack, D. J., Pébay, A., Powell, J. E. & Hewitt, A. W., Dec 18 2018, In: Scientific Data. 5, 1, 180013.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Thyroid hormone signaling specifies cone subtypes in human retinal organoids

Eldred, K. C., Hadyniak, S. E., Hussey, K. A., Brenerman, B., Zhang, P. W., Chamling, X., Sluch, V. M., Welsbie, D. S., Hattar, S., Taylor, J., Wahlin, K., Zack, D. J. & Johnston, R. J., Oct 12 2018, In: Science. 362, 6411, eaau6348.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

2017

Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells

Crombie, D. E., Daniszewski, M., Liang, H. H., Kulkarni, T., Li, F., Lidgerwood, G. E., Conquest, A., Hernández, D., Hung, S. S., Gill, K. P., De Smit, E., Kearns, L. S., Clarke, L., Sluch, V. M., Chamling, X., Zack, D. J., Wong, R. C. B., Hewitt, A. W. & Pébay, A., Sep 1 2017, In: SLAS Discovery. 22, 8, p. 1016-1025 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons

Welsbie, D. S., Mitchell, K. L., Jaskula-Ranga, V., Sluch, V. M., Yang, Z., Kim, J., Buehler, E., Patel, A., Martin, S. E., Zhang, P. W., Ge, Y., Duan, Y., Fuller, J., Kim, B. J., Hamed, E., Chamling, X., Lei, L., Fraser, I. D. C., Ronai, Z. A. & Berlinicke, C. A. & 1 others, Zack, D. J., Jun 21 2017, In: Neuron. 94, 6, p. 1142-1154.e6

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells

Sluch, V. M., Chamling, X., Liu, M. M., Berlinicke, C. A., Cheng, J., Mitchell, K. L., Welsbie, D. S. & Zack, D. J., Nov 2017, In: Stem Cells Translational Medicine. 6, 11, p. 1972-1986 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein

Scott, C. A., Marsden, A. N., Rebagliati, M. R., Zhang, Q., Chamling, X., Searby, C. C., Baye, L. M., Sheffield, V. C. & Slusarski, D. C., Jul 2017, In: PLoS genetics. 13, 7, e1006936.

Research output: Contribution to journal › Article › peer-review

Open Access