William Isaacs

Research output

Research output per year 1979 2001 2002 2003 2004 2005 2007 2008 2009 2011 2012 2016 2017 2020 2021 2022 2023 2024

• 454 Article
• 36 Review article
• 28 Comment/debate
• 6 Chapter
• 12 More
  • 5 Editorial
  • 5 Letter
  • 2 Short survey

Research output per year

Research output per year

Search results

• 2022

  Health inequity drives disease biology to create disparities in prostate cancer outcomes

  Nelson, W. G., Brawley, O. W., Isaacs, W. B., Platz, E. A., Yegnasubramanian, S., Sfanos, K. S., Lotan, T. L. & De Marzo, A. M., Feb 1 2022, In: Journal of Clinical Investigation. 132, 3, e155031.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Drive 100%
  • Prostatic Neoplasms 76%
  • Health 47%
  • European Continental Ancestry Group 38%
  • Social Determinants of Health 37%

• Inherited risk assessment and its clinical utility for predicting prostate cancer from diagnostic prostate biopsies

  Xu, J., Resurreccion, W. K., Shi, Z., Wei, J., Wang, C. H., Zheng, S. L., Hulick, P. J., Ross, A. E., Pavlovich, C. P., Helfand, B. T. & Isaacs, W. B., Sep 2022, In: Prostate Cancer and Prostatic Diseases. 25, 3, p. 422-430 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Risk Assessment 100%
  • Prostatic Neoplasms 95%
  • Biopsy 72%
  • Prostate 36%
  • Mutation 18%

• The role of genetic testing in prostate cancer screening, diagnosis, and treatment

  De La Calle, C. M., Bhanji, Y., Pavlovich, C. P. & Isaacs, W. B., May 1 2022, In: Current opinion in oncology. 34, 3, p. 212-218 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genetic Testing 100%
  • Early Detection of Cancer 91%
  • Prostatic Neoplasms 76%
  • Germ-Line Mutation 18%
  • Mutation 18%
• 2021

  Prostate Cancer Predisposition

  Bhanji, Y., Isaacs, W. B., Xu, J. & Cooney, K. A., Aug 2021, In: Urologic Clinics of North America. 48, 3, p. 283-296 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
• 2020

  Inherited risk assessment of prostate cancer: it takes three to do it right

  Xu, J., Labbate, C. V., Isaacs, W. B. & Helfand, B. T., Mar 1 2020, In: Prostate Cancer and Prostatic Diseases. 23, 1, p. 59-61 3 p.

  Research output: Contribution to journal › Review article › peer-review
  3 Scopus citations
• 2019

  A systematic comparison of exercise training protocols on animal models of cardiovascular capacity

  Feng, R., Wang, L., Li, Z., Yang, R., Liang, Y., Sun, Y., Yu, Q., Ghartey-Kwansah, G., Sun, Y., Wu, Y., Zhang, W., Zhou, X., Xu, M., Bryant, J., Yan, G., Isaacs, W., Ma, J. & Xu, X., Jan 15 2019, In: Life Sciences. 217, p. 128-140 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Cardioprotective 100%
  • Animal Models 48%
  • Exercise 43%
  • Longevity 39%
  • Animals 33%
  15 Scopus citations

• Current progress and questions in germline genetics of prostate cancer

  Isaacs, W. B. & Xu, J., Jan 2019, In: Asian Journal of Urology. 6, 1, p. 3-9 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Prostatic Neoplasms 100%
  • Genetic Profile 54%
  • Genetic Testing 43%
  • Standard of Care 40%
  • Mutation 23%
  6 Scopus citations
• 2018

  Calcium and CaSR/IP3R in prostate cancer development

  Wang, L., Xu, M. M., Li, Z., Shi, M., Zhou, X., Jiang, X., Bryant, J., Balk, S., Ma, J., Isaacs, W. & Xu, X., Feb 27 2018, In: Cell and Bioscience. 8, 1, 16.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Prostatic Neoplasms 100%
  • Calcium(0) 96%
  • Calcium 86%
  • Ryanodine 20%
  • Parathyroid Hormone 20%
  8 Scopus citations
• 2016

  Inflammation, Microbiota, and Prostate Cancer

  Puhr, M., De Marzo, A., Isaacs, W., Lucia, M. S., Sfanos, K., Yegnasubramanian, S. & Culig, Z., Oct 1 2016, In: European Urology Focus. 2, 4, p. 374-382 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Microbiota 100%
  • Prostate 84%
  • Prostatic Neoplasms 80%
  • Inflammation 59%
  • Neoplasms 26%
  23 Scopus citations

• Screening for familial and hereditary prostate cancer

  Lynch, H. T., Kosoko-Lasaki, O., Leslie, S. W., Rendell, M., Shaw, T., Snyder, C., D'Amico, A. V., Buxbaum, S., Isaacs, W. B., Loeb, S., Moul, J. W. & Powell, I., Jun 1 2016, In: International Journal of Cancer. 138, 11, p. 2579-2591 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Familial Prostate cancer 100%
  • Alleles 44%
  • Prostatic Neoplasms 41%
  • Information Centers 22%
  • Genetic Databases 22%
  29 Scopus citations
• 2014

  Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

  Tubio, J. M. C., Li, Y., Ju, Y. S., Martincorena, I., Cooke, S. L., Tojo, M., Gundem, G., Pipinikas, C. P., Zamora, J., Raine, K., Menzies, A., Roman-Garcia, P., Fullam, A., Gerstung, M., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Knappskog, S., Van Loo, P., Ramakrishna, M., & 51 othersDavies, H. R., Marshall, J., Wedge, D. C., Teague, J. W., Butler, A. P., Nik-Zainal, S., Alexandrov, L., Behjati, S., Yates, L. R., Bolli, N., Mudie, L., Hardy, C., Martin, S., McLaren, S., O'Meara, S., Anderson, E., Maddison, M., Gamble, S., Foster, C., Warren, A. Y., Whitaker, H., Brewer, D., Eeles, R., Cooper, C., Neal, D., Lynch, A. G., Visakorpi, T., Isaacs, W. B., Van't Veer, L., Caldas, C., Desmedt, C., Sotiriou, C., Aparicio, S., Foekens, J. A., Eyfjörd, J. E., Lakhani, S. R., Thomas, G., Myklebost, O., Span, P. N., Børresen-Dale, A. L., Richardson, A. L., Van De Vijver, M., Vincent-Salomon, A., Van Den Eynden, G. G., Flanagan, A. M., Futreal, P. A., Janes, S. M., Bova, G. S., Stratton, M. R., McDermott, U. & Campbell, P. J., Aug 1 2014, In: Science. 345, 6196, 1251343.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Long Interspersed Nucleotide Elements 100%
  • Genome 43%
  • DNA 36%
  • Retroelements 21%
  • Neoplasms 20%
  201 Scopus citations
• 2013

  Specific structure and unique function define the hemicentin

  Xu, X., Xu, M. M., Zhou, X., Jones, O. B., Moharomd, E., Pan, Y., Yan, G., Anthony, D. D. & Isaacs, W. B., Jun 26 2013, In: Cell and Bioscience. 3, 1, 27.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Protein 100%
  • Conserved Sequence 98%
  • Cytokinesis 97%
  • Blastocyst 92%
  • Extracellular Matrix Proteins 90%
  24 Scopus citations
• 2012

  Inherited susceptibility for aggressive prostate cancer

  Isaacs, W. B., May 2012, In: Asian Journal of Andrology. 14, 3, p. 415-418 4 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Prostate Cancer, Hereditary, 7 100%
  • Prostatic Neoplasms 49%
  • DNA 35%
  5 Scopus citations

• The role of genetic markers in the management of prostate cancer

  Choudhury, A. D., Eeles, R., Freedland, S. J., Isaacs, W. B., Pomerantz, M. M., Schalken, J. A., Tammela, T. L. J. & Visakorpi, T., Oct 2012, In: European Urology. 62, 4, p. 577-587 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genetic Markers 100%
  • Prostatic Neoplasms 75%
  • Clinical Decision-Making 28%
  • Routine Diagnostic Tests 25%
  • Clinical Trials 17%
  80 Scopus citations
• 2007

  Genetic variability in inflammation pathways and prostate cancer risk

  Sun, J., Turner, A., Xu, J., Grönberg, H. & Isaacs, W., May 2007, In: Urologic Oncology: Seminars and Original Investigations. 25, 3, p. 250-259 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostatic Neoplasms 100%
  • Inflammation 74%
  • Genes 50%
  • Prostate 30%
  • Growth Differentiation Factor 15 27%
  45 Scopus citations

• Inflammation in prostate carcinogenesis

  De Marzo, A. M., Platz, E. A., Sutcliffe, S., Xu, J., Grönberg, H., Drake, C. G., Nakai, Y., Isaacs, W. B. & Nelson, W. G., Apr 2007, In: Nature Reviews Cancer. 7, 4, p. 256-269 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Prostate 100%
  • Epidemiologic Studies 99%
  • Carcinogenesis 91%
  • Inflammation 70%
  • Environmental Exposure 64%
  1104 Scopus citations
• 2006

  Systematic replication study of reported genetic associations in prostate cancer: Strong support for genetic variation in the androgen pathway

  Lindström, S., Zheng, S. L., Wiklund, F., Jonsson, B. A., Adami, H. O., Bälter, K. A., Brookes, A. J., Sun, J., Chang, B. L., Liu, W., Li, G., Isaacs, W. B., Adolfsson, J., Grönberg, H. & Xu, J., Dec 1 2006, In: Prostate. 66, 16, p. 1729-1743 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genetic Association Studies 100%
  • Genetic Variation 90%
  • Androgens 86%
  • Prostatic Neoplasms 74%
  • Neoplasm Genes 20%
  61 Scopus citations
• 2005

  Prostate carcinogenesis and inflammation: Emerging insights

  Palapattu, G. S., Sutcliffe, S., Bastian, P. J., Platz, E. A., De Marzo, A. M., Isaacs, W. B. & Nelson, W. G., Jul 2005, In: Carcinogenesis. 26, 7, p. 1170-1181 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Prostate 100%
  • Prostatic Neoplasms 94%
  • Carcinogenesis 91%
  • Inflammation 70%
  • Men's Health 16%
  295 Scopus citations
• 2004

  Cyclooxygenases in cancer: Progress and perspective

  Zha, S., Yegnasubramanian, V., Nelson, W. G., Isaacs, W. B. & De Marzo, A. M., Nov 8 2004, In: Cancer Letters. 215, 1, p. 1-20 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostaglandin-Endoperoxide Synthases 100%
  • Cyclooxygenase 2 65%
  • Enzymes 42%
  • Non-Steroidal Anti-Inflammatory Agents 33%
  • Neoplasms 30%
  351 Scopus citations

• Pathological and molecular mechanisms of prostate carcinogenesis: Implications for diagnosis, detection, prevention, and treatment

  De Marzo, A. M., DeWeese, T. L., Platz, E. A., Meeker, A. K., Nakayama, M., Epstein, J. I., Isaacs, W. B. & Nelson, W. G., 2004, In: Journal of cellular biochemistry. 91, 3, p. 459-477 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostate 100%
  • Prostatic Neoplasms 94%
  • Carcinogenesis 91%
  • Therapeutics 19%
  • Inflammation 15%
  153 Scopus citations
• 2003

  Looking Beyond Morphology: Cancer Gene Expression Profiling Using DNA Microarrays

  Luo, J., Isaacs, W. B., Trent, J. M. & Duggan, D. J., 2003, In: Cancer Investigation. 21, 6, p. 937-949 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neoplasm Genes 100%
  • Oligonucleotide Array Sequence Analysis 95%
  • Gene Expression Profiling 95%
  • Neoplasms 29%
  • Prostatic Neoplasms 20%
  40 Scopus citations

• Molecular pathways to prostate cancer

  Gonzalgo, M. L. & Isaacs, W. B., Dec 2003, In: Journal of Urology. 170, 6 I, p. 2444-2452 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostatic Neoplasms 100%
  • Molecular Biology 51%
  • Epigenomics 41%
  • Prostate 26%
  • Carcinogenesis 24%
  97 Scopus citations

• Pathological and molecular aspects of prostate cancer

  DeMarzo, A. M., Nelson, W. G., Isaacs, W. B. & Epstein, J. I., Mar 15 2003, In: Lancet. 361, 9361, p. 955-964 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostatic Neoplasms 100%
  • Needle Biopsy 69%
  • Tumor Suppressor Genes 62%
  • Prostatic Intraepithelial Neoplasia 45%
  • Telomere Shortening 41%
  374 Scopus citations

• Prostate cancer

  Nelson, W. G., De Marzo, A. M. & Isaacs, W. B., Jul 24 2003, In: New England Journal of Medicine. 349, 4, p. 366-381 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostatic Neoplasms 100%
  • Genes 36%
  • Atrophy 31%
  • Prostate 30%
  • Steroid 17-alpha-Hydroxylase 26%
  878 Scopus citations

• Where Are the Prostate Cancer Genes? - A Summary of Eight Genome Wide Searches

  Easton, D. F., Schaid, D. J., Whittemore, A. S. & Isaacs, W. J., Dec 1 2003, In: Prostate. 57, 4, p. 261-269 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neoplasm Genes 100%
  • Prostatic Neoplasms 73%
  • Genome 62%
  • Genetic Predisposition to Disease 31%
  90 Scopus citations

• β-Catenin signaling in prostate cancer: An early perspective

  Chesire, D. R. & Isaacs, W. B., Dec 2003, In: Endocrine-related cancer. 10, 4, p. 537-560 24 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Catenins 100%
  • Prostatic Neoplasms 62%
  • Prostate 41%
  • Androgens 27%
  • Androgen Receptors 21%
  105 Scopus citations
• 2001

  Oncogenes and tumor suppressor genes in prostate cancer

  Isaacs, W. & Kainu, T., 2001, In: Epidemiologic reviews. 23, 1, p. 36-41 6 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  21 Scopus citations
• 2000

  G₁/S cell cycle proteins as markers of aggressive prostate carcinoma

  Kibel, A. S. & Isaacs, W. B., Mar 2000, In: Urology. 55, 3, p. 316-322 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  11 Scopus citations
• 1999

  Absence of HinfI restriction abnormalities in renal oncocytoma mitochondrial DNA

  Brooks, J. D., Marshall, F. F., Isaacs, W. B. & Johns, D. R., Jan 1 1999, In: Molecular Urology. 3, 1, p. 1-3 3 p.

  Research output: Contribution to journal › Review article › peer-review

  • Renal oncocytoma 100%
  • Mitochondrial DNA 67%
  • Oxyphilic Adenoma 45%
  • Mitochondrial Genome 40%
  • Digestion 29%
  5 Scopus citations
• 1997

  Molecular advances in prostate cancer

  Dong, J. T., Isaacs, W. B. & Isaacs, J. T., Jan 1 1997, In: Current opinion in oncology. 9, 1, p. 101-107 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostatic Neoplasms 100%
  • Molecular Biology 22%
  • Chromosomes 22%
  • Prostatic Intraepithelial Neoplasia 20%
  • Chromosomes, Human, Pair 8 18%
  74 Scopus citations
• 1996

  DNA methylation, molecular genetic, and linkage studies in prostate cancer.

  Jarrard, D. F., Bova, G. S. & Isaacs, W. B., 1996, In: The Prostate. Supplement. 6, p. 36-44 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genetic Linkage 100%
  • DNA Methylation 75%
  • Molecular Biology 62%
  • Prostatic Neoplasms 60%
  • Sequence Deletion 29%
  14 Scopus citations
• 1995

  Molecular genetics of prostate cancer

  Isaacs, W. B., 1995, In: Cancer Surveys. 25, p. 357-380 24 p.

  Research output: Contribution to journal › Review article › peer-review

  • Molecular Biology 100%
  • Prostatic Neoplasms 97%
  • Loss of Heterozygosity 56%
  • DNA Methylation 48%
  • Point Mutation 48%
  56 Scopus citations
• 1992

  Comparative aspects of multistep prostatic carcinogenesis in humans and rodents.

  Isaacs, J. T., Isaacs, W. B. & Schalken, J., 1992, In: Progress in clinical and biological research. 376, p. 261-288 28 p.

  Research output: Contribution to journal › Review article › peer-review
  5 Scopus citations

• Molecular biology of bladder cancer

  Borland, R. N., Brendler, C. B. & Isaacs, W. B., 1992, In: Hematology/Oncology Clinics of North America. 6, 1, p. 31-40 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Urinary Bladder Neoplasms 100%
  • Molecular Biology 84%
  • Urinary Bladder 62%
  • Carcinogenesis 39%
  • Chromosomes, Human, Pair 9 34%
  21 Scopus citations
• 1991

  Genetic changes associated with prostate cancer in humans

  Isaacs, W. B. & Carter, B. S., 1991, In: Cancer Surveys. 11, p. 15-24 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Prostatic Neoplasms 100%
  • Chromosomes 99%
  • Loss of Heterozygosity 96%
  • Tumor Suppressor Genes 83%
  • ras Genes 50%
  30 Scopus citations

• Titin, a huge, elastic sarcomeric protein with a probable role in morphogenesis

  Fulton, A. B. & Isaacs, W. B., Apr 1991, In: BioEssays. 13, 4, p. 157-161 5 p.

  Research output: Contribution to journal › Review article › peer-review

  • Connectin 100%
  • Morphogenesis 70%
  • Filament 68%
  • Sarcomeres 59%
  • Protein 28%
  56 Scopus citations