WADE Gibson

2014

Nelfinavir inhibits maturation and export of herpes simplex virus 1

Kalu, N. N., Desai, P. J., Shirley, C. M., Gibson, W., Dennis, P. A. & Ambinder, R. F., 2014, In: Journal of virology. 88, 10, p. 5455-5461 7 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Recovery of an HMWP/hmwBP (pUL48/pUL47) complex from virions of human cytomegalovirus: Subunit interactions, oligomer composition, and deubiquitylase activity

Tullman, J. A., Harmon, M. E., Delannoy, M. & Gibson, W., 2014, In: Journal of virology. 88, 15, p. 8256-8267 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

2011

Cytomegalovirus capsid protease: Biological substrates are cleaved more efficiently by full-length enzyme (pUL80a) than by the catalytic domain (assemblin)

Fernandes, S. M., Brignole, E. J. & Gibson, W., Apr 2011, In: Journal of virology. 85, 7, p. 3526-3534 9 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

2009

Cleavage specificity of the UL48 deubiquitinating protease activity of human cytomegalovirus and the growth of an active-site mutant virus in cultured cells

Kim, E. T., Oh, S. E., Lee, Y. O., Gibson, W. & Ahn, J. H., Dec 2009, In: Journal of virology. 83, 23, p. 12046-12056 11 p.

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

2008

Nuclear localization sequences in cytomegalovirus capsid assembly proteins (UL80 proteins) are required for virus production: Inactivating NLS1, NLS2, or both affects replication to strikingly different extents

Nguyen, N. L., Loveland, A. N. & Gibson, W., Jun 2008, In: Journal of virology. 82, 11, p. 5381-5389 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2007

Enzymatic activities of human cytomegaloviras maturational protease assemblin and its precursor (pPR, pUL80a): Maximal activity of pPR requires self-interaction through its scaffolding domain

Brignole, E. J. & Gibson, W., Apr 2007, In: Journal of virology. 81, 8, p. 4091-4103 13 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

The amino-conserved domain of human cytomegalovirus UL80a proteins is required for key interactions during early stages of capsid formation and virus production

Loveland, A. N., Nguyen, N. L., Brignole, E. J. & Gibson, W., Jan 2007, In: Journal of virology. 81, 2, p. 620-628 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

The chemokine receptor homologue encoded by US27 of human cytomegalovirus is heavily glycosylated and is present in infected human foreskin fibroblasts and enveloped virus particles

Margulies, B. J. & Gibson, W., Jan 2007, In: Virus Research. 123, 1, p. 57-71 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

2006

High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: Mutant viruses altered in its active-site cysteine or histidine are viable

Wang, J., Loveland, A. N., Kattenhorn, L. M., Ploegh, H. L. & Gibson, W., Jun 2006, In: Journal of virology. 80, 12, p. 6003-6012 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

2005

Chemical rescue of I-site cleavage in living cells and in vitro discriminates between the cytomegalovirus protease, assemblin, and its precursor, pUL80a

McCartney, S. A., Brignole, E. J., Kolegraff, K. N., Loveland, A. N., Ussin, L. S. M. & Gibson, W., Sep 30 2005, In: Journal of Biological Chemistry. 280, 39, p. 33206-33212 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Cleavage of human cytomegalovirus protease pUL80a at internal and cryptic sites is not essential but enhances infectivity

Loveland, A. N., Chan, C. K., Brignole, E. J. & Gibson, W., Oct 2005, In: Journal of virology. 79, 20, p. 12961-12968 8 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2004

Assembly protein precursor (pUL80.5 homolog) of simian cytomegalovirus is phosphorylated at a glycogen synthase kinase 3 site and its downstream "priming" site: Phosphorylation affects interactions of protein with itself and with major capsid protein

Casaday, R. J., Bailey, J. R., Kalb, S. R., Brignole, E. J., Loveland, A. N., Cotter, R. J. & Gibson, W., Dec 2004, In: Journal of virology. 78, 24, p. 13501-13511 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2003

Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid

Ogawa-Goto, K., Tanaka, K., Gibson, W., Moriishi, E., Miura, Y., Kurata, T., Irie, S. & Sata, T., Aug 2003, In: Journal of virology. 77, 15, p. 8541-8547 7 p.

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

2002

Cytomegalovirus assemblin (pUL80a): Cleavage at internal site not essential for virus growth; proteinase absent from virions

Chan, C. K., Brignole, E. J. & Gibson, W., 2002, In: Journal of virology. 76, 17, p. 8667-8674 8 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2001

Cytomegalovirus basic phosphoprotein (pUL32) binds to capsids in vitro through its amino one-third

Baxter, M. K. & Gibson, W., 2001, In: Journal of virology. 75, 15, p. 6865-6873 9 p.

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

1999

Capsid structure of simian cytomegalovirus from cryoelectron microscopy: Evidence for tegument attachment sites

Trus, B. L., Gibson, W., Cheng, N. & Steven, A. C., 1999, In: Journal of virology. 73, 3, p. 2181-2192 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Phosphorylation of simian cytomegalovirus assembly protein precursor (pAPNG.5) and proteinase precursor (pAPNG1): Multiple attachment sites identified, including two adjacent serines in a casein kinase II consensus sequence

Plafker, S. M., Woods, A. S. & Gibson, W., 1999, In: Journal of virology. 73, 11, p. 9053-9062 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

1998

Cytomegalovirus assembly protein precursor and proteinase precursor contain two nuclear localization signals that mediate their own nuclear translocation and that of the major capsid protein

Plafker, S. M. & Gibson, W., Oct 1998, In: Journal of virology. 72, 10, p. 7722-7732 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Generating random parallel test forms using CTT in a computer-based environment

Gibson, W. M. & Weiner, J. A., 1998, In: Journal of Educational Measurement. 35, 4, p. 297-310 14 p.

Research output: Contribution to journal › Article › peer-review

1997

Assemblin, an essential herpesvirus proteinase

Gibson, W. & Hall, M. R. T., 1997, In: Drug Design and Discovery. 15, 1, p. 39-47 9 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Assemblin homolog of herpes simplex virus type 1 retains proteolytic activity when expressed as a recombinant two-chain enzyme

Hall, M. R. T. & Gibson, W., Jan 6 1997, In: Virology. 227, 1, p. 160-167 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Human cytomegalovirus capsid assembly protein precursor (pUL80.5) Interacts with itself and with the major capsid protein (pUL86) through two different domains

Wood, L. J., Baxter, M. K., Plafker, S. M. & Gibson, W., 1997, In: Journal of virology. 71, 1, p. 179-190 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Independently cloned halves of cytomegalovirus assemblin, A(n) and A(c), can restore proteolytic activity to assemblin mutants by intermolecular complementation

Hall, M. R. T. & Gibson, W., Feb 1997, In: Journal of virology. 71, 2, p. 956-964 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

1996

Cytomegalovirus assemblin: The amino and carboxyl domains of the proteinase form active enzyme when separately cloned and coexpressed in eukaryotic cells

Hall, M. R. T. & Gibson, W., Aug 1996, In: Journal of virology. 70, 8, p. 5395-5404 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Cytomegalovirus 'missing' capsid protein identified as heat-aggregable product of human cytomegalovirus UL46

Gibson, W., Baxter, M. K. & Clopper, K. S., Nov 1996, In: Journal of virology. 70, 11, p. 7454-7461 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Human cytomegalovirus (HCMV) smallest capsid protein identified as product of short open reading frame located between HCMV UL48 and UL49

Gibson, W., Clopper, K. S., Britt, W. J. & Baxter, M. K., Aug 1996, In: Journal of virology. 70, 8, p. 5680-5683 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Identification of the human cytomegalovirus G protein-coupled receptor homologue encoded by UL33 in infected cells and enveloped virus particles

Margulies, B. J., Browne, H. & Gibson, W., Nov 1 1996, In: Virology. 225, 1, p. 111-125 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

Structure and assembly of the virion

Gibson, W., 1996, In: Intervirology. 39, 5-6, p. 389-400 12 p.

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Virus-specific interaction between the human cytomegalovirus major capsid protein and the C terminus of the assembly protein precursor

Beaudet-Miller, M., Zhang, R., Durkin, J., Gibson, W., Kwong, A. D. & Hong, Z., Nov 1996, In: Journal of virology. 70, 11, p. 8081-8088 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

1995

Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals

Gibson, W., Welch, A. R. & Hall, M. R. T., Jul 1995, In: Perspectives in Drug Discovery and Design. 2, 3, p. 413-426 14 p.

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Cytomegalovirus protein substrates are not cleaved by the herpes simplex virus type 1 proteinase

Welch, A. R., Villarreal, E. C. & Gibson, W., Jan 1995, In: Journal of virology. 69, 1, p. 341-347 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Human cytomegalovirus proteinase: Candidate glutamic acid identified as third member of putative active-site triad

Cox, G. A., Wakulchik, M., Sassmannshausen, L. M., Gibson, W. & Villarreal, E. C., Jul 1995, In: Journal of virology. 69, 7, p. 4524-4528 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

1994

Human cytomegalovirus maturational proteinase: Expression in Escherichia coli, purification, and enzymatic characterization by using peptide substrate mimics of natural cleavage sites

Burck, P. J., Berg, D. H., Luk, T. P., Sassmannshausen, L. M., Wakulchik, M., Smith, D. P., Hsiung, H. M., Becker, G. W., Gibson, W. & Villarreal, E. C., May 1994, In: Journal of virology. 68, 5, p. 2937-2946 10 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Site-specific glycosylation of the human cytomegalovirus tegument basic phosphoprotein (UL32) at serine 921 and serine 952

Greis, K. D., Gibson, W. & Hart, G. W., Dec 1994, In: Journal of virology. 68, 12, p. 8339-8349 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Transient transfection assay of the herpesvirus maturational proteinase, assemblin

Gibson, W., Rwelch, A. & Ludford, J. M., Jan 1 1994, In: Methods in enzymology. 244, C, p. 399-411 13 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

1993

Herpesvirus proteinase: Site-directed mutagenesis used to study maturational, release, and inactivation cleavage sites of precursor and to identify a possible catalytic site serine and histidine

Welch, A. R., McNally, L. M., Hall, M. R. T. & Gibson, W., Dec 1993, In: Journal of virology. 67, 12, p. 7360-7372 13 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

1991

A herpesvirus maturational proteinase, assemblin: Identification of its gene, putative active site domain, and cleavage site

Welch, A. R., Woods, A. S., Mcnally, L. M., Cotter, R. J. & Gibson, W., 1991, In: Proceedings of the National Academy of Sciences of the United States of America. 88, 23, p. 10792-10796 5 p.

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Cytomegalovirus assembly protein nested gene family: Four 3′-coterminal transcripts encode four in-frame, overlapping proteins

Welch, A. R., McNally, L. M. & Gibson, W., Aug 1991, In: Journal of virology. 65, 8, p. 4091-4100 10 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Cytomegalovirus homologs of cellular G protein-coupled receptor genes are transcribed

Welch, A. R., Mcgregor, L. M. & Gibson, W., Jul 1991, In: Journal of virology. 65, 7, p. 3915-3918 4 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

The 45-kilodalton protein of cytomegalovirus (colburn) B-capsids is an amino-terminal extension form of the assembly protein

Schenk, P., Woods, A. S. & Gibson, W., 1991, In: Journal of virology. 65, 3, p. 1525-1529 5 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

1990

Evidence that HIV-1 gag precursor shares antigenic sites with the major capsid protein of human cytomegalovirus

Gibson, W., McNally, L. M., Benveniste, R. E. & Ward, J. M., Apr 1990, In: Virology. 175, 2, p. 595-599 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Identification of precursor to cytomegalovirus capsid assembly protein and evidence that processing results in loss of its carboxy-terminal end

Gibson, W., Marcy, A. I., Comolli, J. C. & Lee, J., 1990, In: Journal of virology. 64, 3, p. 1241-1249 9 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Identification of the lyctic origin of DNA replication in human cytomegalovirus by a novel approach utilizing ganciclovir-induced chain termination

Hamzeh, F. M., Lietman, P. S., Gibson, W. & Hayward, G. S., 1990, In: Journal of virology. 64, 12, p. 6184-6195 12 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

Sequence requirements for proteolytic processing of glycoprotein b of human cytomegalovirus strain towne

Spaete, R. R., Saxena, A., Scott, P. I., Song, G. J., Probert, W. S., Britt, W. J., Gibson, W., Rasmussen, L. & Pachl, C., 1990, In: Journal of virology. 64, 6, p. 2922-2931 10 p.

Research output: Contribution to journal › Article › peer-review