Victor Frenkel

2021

MRI Guided Focused Ultrasound-Mediated Delivery of Therapeutic Cells to the Brain: A Review of the State-of-the-Art Methodology and Future Applications

Ahmed, N., Gandhi, D., Melhem, E. R. & Frenkel, V., Jun 17 2021, In: Frontiers in Neurology. 12, 669449.

Research output: Contribution to journal › Review article › peer-review

Open Access

2020

Pulsed focused ultrasound lowers interstitial fluid pressure and increases nanoparticle delivery and penetration in head and neck squamous cell carcinoma xenograft tumors

Mohammadabadi, A., Huynh, R. N., Wadajkar, A. S., Lapidus, R. G., Kim, A. J., Raub, C. B. & Frenkel, V., Jun 21 2020, In: Physics in medicine and biology. 65, 12, 125017.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Design, characterization and evaluation of a laser-guided focused ultrasound system for preclinical investigations

Anastasiadis, P., Mohammadabadi, A., Fishman, M. J., Smith, J. A., Nguyen, B. A., Hersh, D. S. & Frenkel, V., Mar 28 2019, In: BioMedical Engineering Online. 18, 1, 36.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

MR-guided transcranial focused ultrasound safely enhances interstitial dispersion of large polymeric nanoparticles in the living brain

Hersh, D. S., Anastasiadis, P., Mohammadabadi, A., Nguyen, B. A., Guo, S., Winkles, J. A., Kim, A. J., Gullapalli, R., Keller, A., Frenkel, V. & Woodworth, G. F., Feb 2018, In: PloS one. 13, 2, e0192240.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Development of a custom biological scaffold for investigating ultrasound-mediated intracellular delivery

Bui, L., Aleid, A., Alassaf, A., Wilson, O. C., Raub, C. B. & Frenkel, V., Jan 1 2017, In: Materials Science and Engineering C. 70, p. 461-470 10 p.

Research output: Contribution to journal › Article › peer-review

Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

Fishman, P. S. & Frenkel, V., Apr 1 2017, In: Neurotherapeutics. 14, 2, p. 393-404 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Improving the therapeutic efficacy of mesenchymal stromal cells to restore perfusion in critical limb ischemia through pulsed focused ultrasound

Tebebi, P. A., Kim, S. J., Williams, R. A., Milo, B., Frenkel, V., Burks, S. R. & Frank, J. A., Feb 7 2017, In: Scientific reports. 7, 41550.

Research output: Contribution to journal › Article › peer-review

Open Access

Intracranial applications of mr imaging-guided focused ultrasound

Khanna, N., Gandhi, D., Steven, A., Frenkel, V. & Melhem, E. R., Mar 2017, In: American Journal of Neuroradiology. 38, 3, p. 426-431 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

Magnetic enhancement of stem cell–targeted delivery into the brain following MR-guided focused ultrasound for opening the blood–brain barrier

Shen, W. B., Anastasiadis, P., Nguyen, B., Yarnell, D., Yarowsky, P. J., Frenkel, V. & Fishman, P. S., Jul 2017, In: Cell Transplantation. 26, 7, p. 1235-1246 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Notice of Removal: Pulsed focused ultrasound effects on the brain interstitium

Frenkel, V., Hersh, D., Anastasiadis, P., Mohammadabadi, A., Dancy, J., Winkles, J., Keller, A., Woodworth, G. & Kim, A., Oct 31 2017, 2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 8092650. (IEEE International Ultrasonics Symposium, IUS; vol. 0).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2016

Emerging Applications of Therapeutic Ultrasound in Neuro-oncology: Moving beyond Tumor Ablation

Hersh, D. S., Kim, A. J., Winkles, J. A., Eisenberg, H. M., Woodworth, G. F. & Frenkel, V., Nov 1 2016, In: Neurosurgery. 79, 5, p. 643-654 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Evolving drug delivery strategies to overcome the blood brain barrier

Hersh, D. S., Wadajkar, A. S., Roberts, N. B., Perez, J. G., Connolly, N. P., Frenkel, V., Winkles, J. A., Woodworth, G. F. & Kim, A. J., Mar 1 2016, In: Current pharmaceutical design. 22, 9, p. 1177-1193 17 p.

Research output: Contribution to journal › Review article › peer-review

Pulsed ultrasound expands the extracellular and perivascular spaces of the brain

Hersh, D. S., Nguyen, B. A., Dancy, J. G., Adapa, A. R., Winkles, J. A., Woodworth, G. F., Kim, A. J. & Frenkel, V., Sep 1 2016, In: Brain research. 1646, p. 543-550 8 p.

Research output: Contribution to journal › Article › peer-review

2015

Cyclooxygenase-2 or tumor necrosis factor-α inhibitors attenuate the mechanotransductive effects of pulsed focused ultrasound to suppress mesenchymal stromal cell homing to healthy and dystrophic muscle

Tebebi, P. A., Burks, S. R., Kim, S. J., Williams, R. A., Nguyen, B. A., Venkatesh, P., Frenkel, V. & Frank, J. A., Apr 1 2015, In: Stem Cells. 33, 4, p. 1173-1186 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

In vitro methods for evaluating therapeutic ultrasound exposures: Present-day models and future innovations

Alassaf, A., Aleid, A. & Frenkel, V., Nov 1 2013, In: Journal of Therapeutic Ultrasound. 1, 1, 21.

Research output: Contribution to journal › Review article › peer-review

Open Access

Pulsed focused ultrasound exposures enhance locally administered gene therapy in a murine solid tumor model

Ziadloo, A., Xie, J. & Frenkel, V., Mar 2013, In: Journal of the Acoustical Society of America. 133, 3, p. 1827-1834 8 p.

Research output: Contribution to journal › Article › peer-review

2012

Enhanced homing permeability and retention of bone marrow stromal cells by noninvasive pulsed focused ultrasound

Ziadloo, A., Burks, S. R., Gold, E. M., Lewis, B. K., Chaudhry, A., Merino, M. J., Frenkel, V. & Frank, J. A., Jun 2012, In: Stem Cells. 30, 6, p. 1216-1227 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model

Ranjan, A., Jacobs, G. C., Woods, D. L., Negussie, A. H., Partanen, A., Yarmolenko, P. S., Gacchina, C. E., Sharma, K. V., Frenkel, V., Wood, B. J. & Dreher, M. R., Mar 28 2012, In: Journal of Controlled Release. 158, 3, p. 487-494 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pulsed high intensity focused ultrasound increases penetration and therapeutic efficacy of monoclonal antibodies in murine xenograft tumors

Wang, S., Shin, I. S., Hancock, H., Jang, B. S., Kim, H. S., Lee, S. M., Zderic, V., Frenkel, V., Pastan, I., Paik, C. H. & Dreher, M. R., Aug 20 2012, In: Journal of Controlled Release. 162, 1, p. 218-224 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pulsed high-intensity-focused US and tissue plasminogen activator (TPA) versus TPA alone for thrombolysis of occluded bypass graft in swine

Abi-Jaoudeh, N., Pritchard, W. F., Amalou, H., Linguraru, M., Chiesa, O. A., Adams, J. D., Gacchina, C., Wesley, R., Maruvada, S., McDowell, B., Frenkel, V., Karanian, J. W. & Wood, B. J., Jul 2012, In: Journal of Vascular and Interventional Radiology. 23, 7, p. 953-961.e2

Research output: Contribution to journal › Article › peer-review

Ultrasound mediated drug and gene delivery for the treatment of solid tumors

Hancock, H. & Frenkel, V., Jan 1 2012, Molecular Imaging Probes for Cancer Research. World Scientific Publishing Co., p. 769-794 26 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2011

Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects

Krasovitski, B., Frenkel, V., Shoham, S. & Kimmel, E., Feb 22 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 8, p. 3258-3263 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigation of cellular and molecular responses to pulsed focused ultrasound in a mouse model

Burks, S. R., Ziadloo, A., Hancock, H. A., Chaudhry, A., Dean, D. D., Lewis, B. K., Frenkel, V. & Frank, J. A., Sep 13 2011, In: PloS one. 6, 9, e24730.

Research output: Contribution to journal › Article › peer-review

Open Access

Optimization of pulsed focused ultrasound exposures for hyperthermia applications

Wang, S., Frenkel, V. & Zderic, V., Jul 2011, In: Journal of the Acoustical Society of America. 130, 1, p. 599-609 11 p.

Research output: Contribution to journal › Article › peer-review

2010

Extracorporeal, low-energy focused ultrasound for noninvasive and nondestructive targeted hyperthermia

Wang, S., Zderic, V. & Frenkel, V., Sep 2010, In: Future Oncology. 6, 9, p. 1497-1511 15 p.

Research output: Contribution to journal › Review article › peer-review

In vitro investigations into enhancement of tPA bioavailability in whole blood clots using pulsedHigh intensity focused ultrasound exposures

Jones, G., Hunter, F., Hancock, H. A., Kapoor, A., Stone, M. J., Wood, B. J., Xie, J., Dreher, M. R. & Frenkel, V., Jan 2010, In: IEEE Transactions on Biomedical Engineering. 57, 1, p. 33-36 4 p., 5374012.

Research output: Contribution to journal › Article › peer-review

New research directions and novel applications

Frenkel, V., Jan 1 2010, Therapeutic Ultrasound: Mechanisms to Applications. Nova Science Publishers, Inc., p. 297-314 18 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

The multi-faceted nature of therapeutic ultrasound

Frenkel, V., Jan 1 2010, Therapeutic Ultrasound: Mechanisms to Applications. Nova Science Publishers, Inc., p. 1-5 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Therapeutic ultrasound: Mechanisms to applications

Frenkel, V., Jan 1 2010, Nova Science Publishers, Inc. 335 p.

Research output: Book/Report › Book

2009

Evaluation of pulsed high intensity focused ultrasound exposures on metastasis in a murine model

Hancock, H., Dreher, M. R., Crawford, N., Pollock, C. B., Shih, J., Wood, B. J., Hunter, K. & Frenkel, V., Oct 2009, In: Clinical and Experimental Metastasis. 26, 7, p. 729-738 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigations into Pulsed High-Intensity Focused Ultrasound-Enhanced Delivery: Preliminary Evidence for a Novel Mechanism

Hancock, H. A., Smith, L. H., Cuesta, J., Durrani, A. K., Angstadt, M., Palmeri, M. L., Kimmel, E. & Frenkel, V., Oct 2009, In: Ultrasound in Medicine and Biology. 35, 10, p. 1722-1736 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Preliminary optimization of non-destructive high intensity focused ultrasound exposures for hyperthermia applications

Wang, S., Frenkel, V. & Zderic, V., 2009, Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. IEEE Computer Society, p. 3055-3059 5 p. 5333582. (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pulsed High Intensity Focused Ultrasound Mediated Nanoparticle Delivery: Mechanisms and Efficacy in Murine Muscle

O'Neill, B. E., Vo, H., Angstadt, M., Li, K. P. C., Quinn, T. & Frenkel, V., Mar 2009, In: Ultrasound in Medicine and Biology. 35, 3, p. 416-424 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2008

In vitro and in vivo evaluations of increased effective beam width for heat deposition using a split focus high intensity ultrasound (HIFU) transducer

Patel, P. R., Luk, A., Durrani, A., Dromi, S., Cuesta, J., Angstadt, M., Dreher, M. R., Wood, B. J. & Frenkel, V., 2008, In: International Journal of Hyperthermia. 24, 7, p. 537-549 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pulsed high-intensity focused ultrasound enhances apoptosis and growth inhibition of squamous cell carcinoma xenografts with proteasome inhibitor bortezomib

Poff, J. A., Allen, C. T., Traughber, B., Colunga, A., Xie, J., Chen, Z., Wood, B. J., Van Waes, C., Li, K. C. P. & Frenkel, V., Aug 2008, In: RADIOLOGY. 248, 2, p. 485-491 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice

Khaibullina, A., Jang, B. S., Sun, H., Le, N., Yu, S., Frenkel, V., Carrasquillo, J. A., Pastan, I., Li, K. C. P. & Paik, C. H., Feb 1 2008, In: Journal of Nuclear Medicine. 49, 2, p. 295-302 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Ultrasound mediated delivery of drugs and genes to solid tumors

Frenkel, V., Jun 30 2008, In: Advanced Drug Delivery Reviews. 60, 10, p. 1193-1208 16 p.

Research output: Contribution to journal › Review article › peer-review

2007

Investigations into the potential contribution of a thermal mechanism for pulsed high intensity focused ultrasound mediated delivery

O'Neill, B. E., Li, K. C. P., Frenkel, V., Vo, H., Angstadt, M., Wood, B. J. & Quinn, T. P., 2007, 2007 IEEE Ultrasonics Symposium Proceedings, IUS. p. 1-4 4 p. 4409589. (Proceedings - IEEE Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pulsed-high intensity focused ultrasound and low temperature - Sensitive liposomes for enhanced targeted drug delivery and antitumor effect

Dromi, S., Frenkel, V., Luk, A., Traughber, B., Angstadt, M., Bur, M., Poff, J., Xie, J., Libutti, S. K., Li, K. C. P. & Wood, B. J., May 1 2007, In: Clinical Cancer Research. 13, 9, p. 2722-2727 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pulsed-high intensity focused ultrasound enhanced tPA mediated thrombolysis in a novel in vivo clot model, a pilot study

Stone, M. J., Frenkel, V., Dromi, S., Thomas, P., Lewis, R. P., Li, K. C. P., Horne, M. & Wood, B. J., 2007, In: Thrombosis research. 121, 2, p. 193-202 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2006

CT and ultrasound guided stereotactic high intensity focused ultrasound (HIFU)

Wood, B. J., Yanof, J., Frenkel, V., Viswanathan, A., Dromi, S., Oh, K., Kruecker, J., Bauer, C., Seip, R., Kam, A. W. & Li, K. C. P., May 8 2006, THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. American Institute of Physics Inc., p. 122-126 5 p. (AIP Conference Proceedings; vol. 829).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Delivery of liposomal doxorubicin (Doxil) in a breast cancer tumor model: Investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure

Frenkel, V., Etherington, A., Greene, M., Quijano, J., Xie, J., Hunter, F., Dromi, S. & Li, K. C. P., Apr 2006, In: Academic radiology. 13, 4, p. 469-479 11 p.

Research output: Contribution to journal › Article › peer-review

Erratum: Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis (Stem Cells (March 2006) 24 (671-678) doi: 10.1634/stemcells.2005- 0017)

Arbab, A. S., Pandit, S. D., Anderson, S. A., Yocuma, G. T., Bur, M., Frenkel, V., Khuu, H. M., Read, E. J. & Frank, J. A., Apr 2006, In: Stem Cells. 24, 4, p. 1142 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Magnetic resonance imaging and confocal microscopy studies of magnetically labeled endothelial progenitor cells trafficking to sites of tumor angiogenesis

Arbab, A. S., Frenkel, V., Pandit, S. D., Anderson, S. A., Yocum, G. T., Bur, M., Khuu, H. M., Read, E. J. & Frank, J. A., Mar 2006, In: Stem Cells. 24, 3, p. 671-678 8 p.

Research output: Contribution to journal › Article › peer-review

Potential role of pulsed-high intensity focused ultrasound in gene therapy

Frenkel, V. & Li, K. C. P., Feb 2006, In: Future Oncology. 2, 1, p. 111-119 9 p.

Research output: Contribution to journal › Review article › peer-review

Pulsed-high intensity focused ultrasound (HIFU) exposures for enhanced delivery of therapeutics: Mechanisms and applications

Frenkel, V., Deng, C., O'Neill, B. E., Quijano, J., Stone, M. J., Dromi, S., Hunter, F., Xie, J., Quinn, T. P., Wood, B. J. & Li, K. C. P., May 8 2006, THERAPEUTIC ULTRASOUND: 5th International Symposium on Therapeutic Ultrasound. p. 528-532 5 p. (AIP Conference Proceedings; vol. 829).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Pulsed high-intensity focused ultrasound enhances thrombolysis in an in vitro model

Frenkel, V., Oberoi, J., Stone, M. J., Park, M., Deng, C., Wood, B. J., Neeman, Z., Horne, M. & Li, K. C. P., Apr 2006, In: RADIOLOGY. 239, 1, p. 86-93 8 p.

Research output: Contribution to journal › Article › peer-review

2005

Victor Frenkel

Research output

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