Vickie Sinibaldi

2024

Bipolar androgen therapy plus nivolumab for patients with metastatic castration-resistant prostate cancer: the COMBAT phase II trial

Markowski, M. C., Taplin, M. E., Aggarwal, R., Sena, L. A., Wang, H., Qi, H., Lalji, A., Sinibaldi, V., Carducci, M. A., Paller, C. J., Marshall, C. H., Eisenberger, M. A., Sanin, D. E., Yegnasubramanian, S., Gomes-Alexandre, C., Ozbek, B., Jones, T., De Marzo, A. M., Denmeade, S. R. & Antonarakis, E. S., Dec 2024, In: Nature communications. 15, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A Multicohort Open-label Phase II Trial of Bipolar Androgen Therapy in Men with Metastatic Castration-resistant Prostate Cancer (RESTORE): A Comparison of Post-abiraterone Versus Post-enzalutamide Cohorts

Markowski, M. C., Wang, H., Sullivan, R., Rifkind, I., Sinibaldi, V., Schweizer, M. T., Teply, B. A., Ngomba, N., Fu, W., Carducci, M. A., Paller, C. J., Marshall, C. H., Eisenberger, M. A., Luo, J., Antonarakis, E. S. & Denmeade, S. R., May 2021, In: European Urology. 79, 5, p. 692-699 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Bipolar androgen therapy sensitizes castration-resistant prostate cancer to subsequent androgen receptor ablative therapy

Sena, L. A., Wang, H., Lim ScM, S. J., Rifkind, I., Ngomba, N., Isaacs, J. T., Luo, J., Pratz, C., Sinibaldi, V., Carducci, M. A., Paller, C. J., Eisenberger, M. A., Markowski, M. C., Antonarakis, E. S. & Denmeade, S. R., Feb 2021, In: European Journal of Cancer. 144, p. 302-309 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Bipolar androgen therapy in men with metastatic castration-resistant prostate cancer after progression on enzalutamide: an open-label, phase 2, multicohort study

Teply, B. A., Wang, H., Luber, B., Sullivan, R., Rifkind, I., Bruns, A., Spitz, A., DeCarli, M., Sinibaldi, V., Pratz, C. F., Lu, C., Silberstein, J. L., Luo, J., Schweizer, M. T., Drake, C. G., Carducci, M. A., Paller, C. J., Antonarakis, E. S., Eisenberger, M. A. & Denmeade, S. R., Jan 2018, In: The Lancet Oncology. 19, 1, p. 76-86 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2016

Is there a "trial effect" on outcome of patients with metastatic renal cell carcinoma treated with sunitinib?

Keizman, D., Rouvinov, K., Sella, A., Gottfried, M., Maimon, N., Kim, J. J., Eisenberger, M. A., Sinibaldi, V., Peer, A., Carducci, M. A., Mermershtain, W., Leibowitz-amit, R., Weitzen, R. & Berger, R., 2016, In: Cancer Research and Treatment. 48, 1, p. 281-287 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Metformin Use and Outcome of Sunitinib Treatment in Patients With Diabetes and Metastatic Renal Cell Carcinoma

Keizman, D., Ish-Shalom, M., Sella, A., Gottfried, M., Maimon, N., Peer, A., Hammers, H., Eisenberger, M. A., Sinibaldi, V., Neiman, V., Rosenbaum, E., Sarid, D., Mermershtain, W., Rouvinov, K., Berger, R. & Carducci, M. A., Oct 1 2016, In: Clinical Genitourinary Cancer. 14, 5, p. 420-425 6 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Outcome of patients with metastatic chromophobe renal cell carcinoma treated with sunitinib

Keizman, D., Sarid, D., Lee, J. L., Sella, A., Gottfried, M., Hammers, H., Eisenberger, M. A., Carducci, M. A., Sinibaldi, V., Neiman, V., Rosenbaum, E., Peer, A., Neumann, A., Mermershtain, W., Rouvinov, K., Berger, R. & Yildiz, I., Oct 2016, In: Oncologist. 21, 10, p. 1212-1217 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Prognostic factors for clinical outcomes in patients with metastatic castration resistant prostate cancer treated with sequential novel androgen receptor-directed therapies

Nadal, R., Tsai, H. L., Sinibaldi, V. J., Paller, C. J., Antonarakis, E. S., Denmeade, S. R., Carducci, M. A. & Eisenberger, M. A., Apr 1 2016, In: Prostate. 76, 5, p. 512-520 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2014

Active smokingmay negatively affect response rate, progression-free survival, and overall survival of patients with metastatic renal cell carcinoma treatedwith sunitinib

Keizman, D., Gottfried, M., Ish-Shalom, M., Maimon, N., Peer, A., Neumann, A., Hammers, H., Eisenberger, M. A., Sinibaldi, V., Pili, R., Hayat, H., Kovel, S., Sella, A., Boursi, B., Weitzen, R., Mermershtain, W., Rouvinov, K., Berger, R. & Carducci, M. A., 2014, In: Oncologist. 19, 1, p. 51-60 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

American Cancer Society prostate cancer survivorship care guidelines

Skolarus, T. A., Wolf, A. M. D., Erb, N. L., Brooks, D. D., Rivers, B. M., Underwood, W., Salner, A. L., Zelefsky, M. J., Aragon-Ching, J. B., Slovin, S. F., Wittmann, D. A., Hoyt, M. A., Sinibaldi, V. J., Chodak, G., Pratt-Chapman, M. L. & Cowens-Alvarado, R. L., 2014, In: CA Cancer Journal for Clinicians. 64, 4, p. 225-249 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

228 Scopus citations

Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel

Peer, A., Gottfried, M., Sinibaldi, V., Carducci, M. A., Eisenberger, M. A., Sella, A., Leibowitz-Amit, R., Berger, R. & Keizman, D., Apr 2014, In: Prostate. 74, 4, p. 433-440 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2012

Bisphosphonates combined with sunitinib may improve the response rate, progression free survival and overall survival of patients with bone metastases from renal cell carcinoma

Keizman, D., Ish-Shalom, M., Pili, R., Hammers, H., Eisenberger, M. A., Sinibaldi, V., Boursi, B., Maimon, N., Gottfried, M., Hayat, H., Peer, A., Kovel, S., Sella, A., Berger, R. & Carducci, M. A., May 2012, In: European Journal of Cancer. 48, 7, p. 1031-1037 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Pretreatment neutrophil-to-lymphocyte ratio in metastatic castration-resistant prostate cancer patients treated with ketoconazole: Association with outcome and predictive nomogram

Keizman, D., Gottfried, M., Ish-Shalom, M., Maimon, N., Peer, A., Neumann, A., Rosenbaum, E., Kovel, S., Pili, R., Sinibaldi, V., Carducci, M. A., Hammers, H., Eisenberger, M. A. & Sella, A., 2012, In: Oncologist. 17, 12, p. 1508-1514 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

2011

Phase I trial with a combination of docetaxel and ¹⁵³Sm-lexidronam in patients with castration-resistant metastatic prostate cancer

Lin, J., Sinibaldi, V. J., Carducci, M. A., Denmeade, S., Song, D., DeWeese, T. & Eisenberger, M. A., Nov 2011, In: Urologic Oncology: Seminars and Original Investigations. 29, 6, p. 670-675 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

The change of PSA doubling time and its association with disease progression in patients with biochemically relapsed prostate cancer treated with intermittent androgen Deprivation

Keizman, D., Huang, P., Antonarakis, E. S., Sinibaldi, V., Carducci, M. A., Denmeade, S., Kim, J. J., Walczak, J. & Eisenberger, M. A., Nov 2011, In: Prostate. 71, 15, p. 1608-1615 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

TNF-blockade in patients with advanced hormone refractory prostate cancer

Diaz, L. A., Messersmith, W., Sokoll, L., Sinibaldi, V., Moore, S., Carducci, M. & Eisenberger, M., Feb 2011, In: Investigational New Drugs. 29, 1, p. 192-194 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2010

Lenalidomide in nonmetastatic biochemically relapsed prostate cancer: Results of a phase I/II double-blinded, randomized study

Keizman, D., Zahurak, M., Sinibaldi, V., Carducci, M., Denmeade, S., Drake, C., Pili, R., Antonarakis, E. S., Hudock, S. & Eisenberger, M., Nov 1 2010, In: Clinical Cancer Research. 16, 21, p. 5269-5276 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2008

New science and therapeutic advances in the treatment of renal cell carcinoma: A case study review

Sinibaldi, V. J., Feb 1 2008, In: Johns Hopkins Advanced Studies in Nursing. 6, 1, p. 1+4

Research output: Contribution to journal › Article › peer-review

2007

Phase II Study of Imatinib Mesylate in Patients with Prostate Cancer with Evidence of Biochemical Relapse After Definitive Radical Retropubic Prostatectomy or Radiotherapy

Bajaj, G. K., Zhang, Z., Garrett-Mayer, E., Drew, R., Sinibaldi, V., Pili, R., Denmeade, S. R., Carducci, M. A., Eisenberger, M. A. & DeWeese, T. L., Mar 1 2007, In: Urology. 69, 3, p. 526-531 6 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Preclinical and clinical studies with the multi-kinase inhibitor CEP-701 as treatment for prostate cancer demonstrate the inadequacy of PSA response as a primary endpoint

Collins, C., Carducci, M. A., Eisenberger, M. A., Isaacs, J. T., Partin, A. W., Pili, R., Sinibaldi, V. J., Walczak, J. S. & Denmeade, S. R., Sep 2007, In: Cancer Biology and Therapy. 6, 9, p. 1356-1363 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2006

Phase II evaluation of docetaxel plus exisulind in patients with androgen independent prostate carcinoma

Sinibaldi, V. J., Elza-Brown, K., Schmidt, J., Eisenberger, M. A., Rosenbaum, E., Denmeade, S. R., Pili, R., Walczak, J., Baker, S. D., Zahurak, M. & Carducci, M. A., Aug 2006, In: American Journal of Clinical Oncology: Cancer Clinical Trials. 29, 4, p. 395-398 4 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2005

Marimastat in the treatment of patients with biochemically relapsed prostate cancer: A prospective randomized, double-blind, phase I/II trial

Rosenbaum, E., Zahurak, M., Sinibaldi, V., Carducci, M. A., Pili, R., Laufer, M., DeWeese, T. L. & Eisenberger, M. A., Jun 15 2005, In: Clinical Cancer Research. 11, 12, p. 4437-4443 7 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

2004

A Phase II Trial of Temozolomide and IFN-α in Patients with Advanced Renal Cell Carcinoma

Sunkara, U., Walczak, J. R., Summerson, L., Rogers, T., Eisenberger, M., Denmeade, S., Pili, R., Huff, C. A., Sinibaldi, V. & Carducci, M. A., Jan 2004, In: Journal of Interferon and Cytokine Research. 24, 1, p. 37-41 5 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Phase I and clinical pharmacology of a type I and II, 5-alpha-reductase inhibitor (LY320236) in prostate cancer: Elevation of estradiol as possible mechanism of action

Eisenberger, M., Laufer, M., Vogelzang, N. J., Sartor, O., Thornton, D., Neubauer, B. L., Sinibaldi, V., Lieskovsky, G., Carducci, M. A., Zahurak, M. & Raghavan, D., Jan 2004, In: Urology. 63, 1, p. 114-119 6 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

2002

Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: Safety and pharmacokinetics

Carducci, M. A., Nelson, J. B., Bowling, M. K., Rogers, T., Eisenberger, M. A., Sinibaldi, V., Donehower, R., Leahy, T. L., Carr, R. A., Isaacson, J. D., Janus, T. J., Andre, A., Hosmane, B. S. & Padley, R. J., Apr 15 2002, In: Journal of Clinical Oncology. 20, 8, p. 2171-2180 10 p.

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Phase II evaluation of docetaxel plus one-day oral estramustine phosphate in the treatment of patients with androgen independent prostate carcinoma

Sinibaldi, V. J., Carducci, M. A., Moore-Cooper, S., Laufer, M., Zahurak, M. & Eisenberger, M. A., Mar 1 2002, In: Cancer. 94, 5, p. 1457-1465 9 p.

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

2001

A phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule

Carducci, M. A., Gilbert, J., Bowling, M. K., Eisenberger, M. A., Sinibaldi, V., Grochow, L. B., Donehower, R. C., Carducci, M. A., Noe, D., Zabelina, Y., Chen, T. L. & Grochow, L. B., 2001, In: Clinical Cancer Research. 7, 10, p. 3047-3055 9 p.

Research output: Contribution to journal › Article › peer-review

189 Scopus citations

Clinical conduct and nursing quality of life in prostate cancer

Sinibaldi, V. J. & Arzoomanian, R. Z., Jan 1 2001, In: Hematology/Oncology Clinics of North America. 15, 3, p. 573-581 9 p.

Research output: Contribution to journal › Article › peer-review

1999

Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: Recommendations from the prostate- specific antigen working group

Bubley, G. J., Carducci, M., Dahut, W., Dawson, N., Daliani, D., Eisenberger, M., Figg, W. D., Freidlin, B., Halabi, S., Hudes, G., Hussain, M., Kaplan, R., Myers, C., Oh, W., Petrylak, D. P., Reed, E., Roth, B., Sartor, O., Scher, H., Simons, J., & 6 othersSinibaldi, V., Small, E. J., Smith, M. R., Trump, D. L., Vollmer, R. & Wilding, G., Nov 1999, In: Journal of Clinical Oncology. 17, 11, p. 3461-3467 7 p.

Research output: Contribution to journal › Article › peer-review

888 Scopus citations

Rapid disease progression after the administration of bicalutamide in patients with metastatic prostate cancer.

Laufer, M., Sinibaldi, V. J., Carducci, M. A. & Eisenberger, M. A., Oct 1999, In: Urology. 54, 4, p. 745 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

1998

Evaluation of biomarkers of survival response in hormone-refractory prostate cancer patients treated with suramin

Sridhara, R., Eisenberger, M. A., Sinibaldi, V. J., Reyno, L. M. & Egorin, M. J., Jul 1998, In: Cancer Epidemiology Biomarkers and Prevention. 7, 7, p. 631-634 4 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

1996

A prospective study of suramin-induced peripheral neuropathy

Chaudhry, V., Eisenberger, M. A., Sinibaldi, V. J., Sheikh, K., Griffin, J. W. & Cornblath, D. R., 1996, In: Brain. 119, 6, p. 2039-2052 14 p.

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Ocular symptoms and signs associated with suramin sodium treatment for metastatic cancer of the prostate

Hemady, R. K., Sinibaldi, V. J. & Eisenberger, M. A., 1996, In: American journal of ophthalmology. 121, 3, p. 291-296 6 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Prostate cancer treatment strategies based on tumor-specific biological principles: Future directions

Carducci, M. A., DeWeese, T. L., Nelson, W. G., Simons, J. W., Sinibaldi, V. & Eisenberger, M. A., 1996, In: Seminars in oncology. 23, 6 SUPPL. 14, p. 56-62 7 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

1995

Combined carboplatin plus bleomycin and conventional radiotherapy for advanced carcinomas of the head and neck

Espinoza-Jacobs, M. C., Suntharalingam, M., Eisenberger, M., Sinibaldi, V. & Salazar, O. M., 1995, In: American Journal of Clinical Oncology: Cancer Clinical Trials. 18, 1, p. 52-55 4 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Development and validation of a pharmacokinetically based fixed dosing scheme for suramin

Reyno, L. M., Egorin, M. J., Eisenberger, M. A., Sinibaldi, V. J., Zuhowski, E. G. & Sridhara, R., Sep 1995, In: Journal of Clinical Oncology. 13, 9, p. 2187-2195 9 p.

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Evaluation of prostate-specific antigen as a surrogate marker for response of hormone-refractory prostate cancer to suramin therapy

Sridhara, R., Eisenberger, M. A., Sinibaldi, V. J., Reyno, L. M. & Egorin, M. J., Dec 1995, In: Journal of Clinical Oncology. 13, 12, p. 2944-2953 10 p.

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Phase I and clinical evaluation of a pharmacologically guided regimen of suramin in patients with hormone-refractory prostate cancer

Eisenberger, M. A., Sinibaldi, V. J., Reyno, L. M., Sridhara, R., Jodrell, D. I., Zuhowski, E. G., Tkaczuk, K. H., Lowitt, M. H., Hemady, R. K., Jacobs, S. C., VanEcho, D. & Egorin, M. J., Sep 1995, In: Journal of Clinical Oncology. 13, 9, p. 2174-2186 13 p.

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

The experience with suramin in advanced prostate cancer

Eisenberger, M. A., Reyno, L., Sinibaldi, V., Sridhara, R., Carducci, M. & Egorin, M., Apr 1 1995, In: Cancer. 75, 7 S, p. 1927-1934 8 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

1994

Suramin: Development of a population pharmacokinetic model and its use with intermittent short infusions to control plasma drug concentration in patients with prostate cancer

Jodrell, D. I., Reyno, L. M., Sridhara, R., Eisenberger, M. A., Tkaczuk, K. H., Zuhowski, E. G., Sinibaldi, V. J., Novak, M. J. & Egorin, M. J., Jan 1994, In: Journal of Clinical Oncology. 12, 1, p. 166-175 10 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

1993

Suramin, an active drug for prostate cancer: Interim observations in a phase I trial

Eisenberger, M. A., Reyno, L. M., Jodrell, D. I., Sinibaldi, V. J., Tkaczuk, K. H., Sridhara, R., Zuhowski, E. G., Lowitt, M. H., Jacobs, S. C. & Egorin, M. J., Apr 21 1993, In: Journal of the National Cancer Institute. 85, 8, p. 611-621 11 p.

Research output: Contribution to journal › Article › peer-review

127 Scopus citations

1992

Approaches to optimal dosing of hexamethylene bisacetamide

Conley, B. A., Egorin, M. J., Sinibaldi, V., Sewack, G., Kloc, C., Roberts, L., Zuhowski, E. G., Forrest, A. & Van Echo, D. A., Jan 1992, In: Cancer Chemotherapy and Pharmacology. 31, 1, p. 37-45 9 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Carboplatin in the treatment of squamous cell head and neck cancers

Aisner, J., Sinibaldi, V. & Eisenberger, M., Feb 1992, In: Seminars in oncology. 19, 1 SUPPL. 2, p. 60-65 6 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

Kruter, F., Eisenberger, M., Sinibaldi, V., Engstrom, C., Jacobs, M., Abrams, J., Belani, C., Gray, W. & Krasnow, S., Jun 1992, In: Investigational New Drugs. 10, 2, p. 89-91 3 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

1990

Tolerance of full dose menogaril (NSC 269148) in patients with abnormal hepatic and renal function

Conley, B. A., Egorin, M. J., Sinibaldi, V. & Van Echo, D. A., Nov 1990, In: Investigational New Drugs. 8, 4, p. 365-367 3 p.

Research output: Contribution to journal › Article › peer-review

1989

A comparison of carboplatin plus methotrexate versus methotrexate alone in patients with recurrent and metastatic head and neck cancer

Eisenberger, M., Krasnow, S., Ellenberg, S., Silva, H., Abrams, J., Sinibaldi, V., Van Echo, D. & Aisner, J., 1989, In: Journal of Clinical Oncology. 7, 9, p. 1341-1345 5 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Carboplatin (CBDCA) and radiotherapy for stage IV carcinoma of the head and neck: A phase I-II study

Jacobs, M. C., Eisenberger, M., Min Chu Oh, C. O., Sinibaldi, V., Gray, W., Elias, G. & Salazar, O. M., Aug 1989, In: International journal of radiation oncology, biology, physics. 17, 2, p. 361-363 3 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Phase I Trial Using Adaptive Control Dosing of Hexamethylene Bisacetamide (NSC 95580)

Conley, B. A., Forrest, A., Egorin, M. J., Zuhowski, E. G., Sinibaldi, V. & Van Echo, D. A., Jun 15 1989, In: Cancer Research. 49, 12, p. 3436-3440 5 p.

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

1988

Salivary concentrations of hexamethylene bisacetamide (HMBA) in patients receiving 5-day continuous infusions

Conley, B. A., Egorin, M. J., Zuhowski, E. G., Sinibaldi, V. J. & Peterson, D. E., Jul 1988, In: Cancer Chemotherapy and Pharmacology. 22, 1, p. 65-68 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Simultaneous treatment with carboplatin (nsc-241-240) and radiotherapy in advanced unresectable squamous cell carcinomas of the head and neck

Eisenberger, M., Sinibaldi, V., Jacobs, M. & Gray, W., Jun 1988, In: Cancer Treatment Reviews. 15, SUPPL. B, p. 3-7 5 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Vickie Sinibaldi

Research output

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