Thomas Hartung

Research output

Research output per year 1991 2001 2002 2003 2004 2005 2006 2007 2008 2009 2013 2014 2015 2016 2017 2018 2020 2021 2022 2023 2024

• 418 Article
• 90 Review article
• 27 Editorial
• 19 Comment/debate
• 30 More
  • 18 Chapter
  • 6 Letter
  • 6 Short survey

Research output per year

Research output per year

Search results

• 2024

  Environmentally Relevant Concentrations of Tetrabromobisphenol A Exposure Impends Neurovascular Formation through Perturbing Mitochondrial Metabolism in Zebrafish Embryos and Human Primary Endothelial Cells

  Zeng, X., Ma, S., Luo, Y., Zhang, Y., Wang, Q., Zhang, Z., Ke, W., Ma, Y., Hu, H., Hartung, T., Wei, Y. & Zhong, X., Mar 26 2024, In: Environmental Science and Technology. 58, 12, p. 5267-5278 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2023

  4.2 Million and Counting… The Animal Toll for REACH Systemic Toxicity Studies

  Knight, J., Hartung, T. & Rovida, C., 2023, In: ALTEX. 40, 3, p. 389-407 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Animals 100%
  • Toxicity Tests 75%
  • Ecosystem 20%
  • Health 17%
  • Compliance 16%

• Artificial intelligence as the new frontier in chemical risk assessment

  Hartung, T., 2023, In: Frontiers in Artificial Intelligence. 6, 1269932.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Risk assessment 100%
  • Artificial intelligence 89%
  • Animals 49%
  • Big data 46%

• CellTox Days 2022 – Inside the Barriers: In Vitro Models and Their Applications

  Steimberg, N., Alloisio, S., Vincentini, O., Caloni, F., Baderna, D., Dellambra, E., Monache, F. D., Sbrana, T., Scaglione, S., Letasiova, S., Cattaneo, A., Ludovico, A., Hartung, T., Colacci, A., Markus, J., Rescigno, F., Piccapane, F., Occhetta, P. & Scagnoli, F., 2023, In: ALTEX. 40, 1, p. 160-164 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Food for Thought … REACH Out-Numbered! The Future of REACH and Animal Numbers

  Rovida, C., Busquet, F., Leist, M. & Hartung, T., 2023, In: ALTEX. 40, 3, p. 367-388 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Animals 100%
  • Compliance 32%
  • Chemical Safety 28%
  • Polymers 16%

• Human brain microphysiological systems in the study of neuroinfectious disorders

  Barreras, P., Pamies, D., Hartung, T. & Pardo, C. A., Jul 2023, In: Experimental Neurology. 365, 114409.

  Research output: Contribution to journal › Article › peer-review

  • Organoids 100%
  • Brain 74%
  • Bioprinting 57%
  • SARS Virus 56%
  • Japanese Encephalitis 55%

• Organoid Intelligence (OI) – The Ultimate Functionality of a Brain Microphysiological System

  Smirnova, L., Morales Pantoja, I. E. & Hartung, T., 2023, In: ALTEX. 40, 2, p. 191-203 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Organoids 100%
  • Intelligence 80%
  • Cognition 48%
  • Brain 37%
  • Long-Term Memory 35%

• Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development

  Jordan, R., Ford-Scheimer, S. L., Alarcon, R. M., Atala, A., Borenstein, J. T., Brimacombe, K. R., Cherry, S., Clevers, H., Davis, M. I., Funnell, S. G. P., Gehrke, L., Griffith, L. G., Grossman, A. C., Hartung, T., Ingber, D. E., Kleinstreuer, N. C., Kuo, C. J., Lee, E. M., Mummery, C. L., Pickett, T. E., & 8 othersRamani, S., Rosado-Olivieri, E. A., Struble, E. B., Wan, Z., Williams, M. S., Hall, M. D., Ferrer, M. & Markossian, S., Oct 1 2023, In: Journal of Infectious Diseases. 228, p. S337-S354

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Development 100%
  • Antiviral Agents 90%
  • Education 66%
  • National Institute of Allergy and Infectious Diseases (U.S.) 27%
  • Manuals 20%

• The Good, The Bad, and The Perplexing: Structural Alerts and Read-Across for Predicting Skin Sensitization Using Human Data

  Golden, E., Ukaegbu, D. C., Ranslow, P., Brown, R. H., Hartung, T. & Maertens, A., May 15 2023, In: Chemical research in toxicology. 36, 5, p. 734-746 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Quantitative Structure-Activity Relationship 100%
  • Organisation for Economic Co-Operation and Development 83%
  • Sensitization 77%
  • Datasets 57%
  • Skin 40%

• ToxAIcology - The evolving role of artificial intelligence in advancing toxicology and modernizing regulatory science

  Hartung, T., 2023, In: ALTEX. 40, 4, p. 559-570 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Artificial Intelligence 100%
  • Toxicology 73%
  • Expert Systems 20%
  • Deep Learning 20%
  • Quantitative Structure-Activity Relationship 20%

• Using in silico tools to predict flame retardant metabolites for more informative exposomics-based approaches

  Kincaid, B., Piechota, P., Golden, E., Maertens, M., Hartung, T. & Maertens, A., 2023, In: Frontiers in Toxicology. 5, 1216802.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Flame Retardants 100%
  • Flame Retardant 70%
  • Computer Simulation 64%
  • Metabolic 25%
  • Hazardous Substance 14%
• 2022

  A call for a Human Exposome Project

  Hartung, T., 2022, In: ALTEX. 40, 1, p. 4-33 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exposome 100%
  • Artificial Intelligence 25%
  • Human Genome Project 13%
  • Big Data 13%
  • Biological Monitoring 12%

• A human-derived 3D brain organoid model to study JC virus infection

  Barreras, P., Pamies, D., Monaco, M. C., Muñoz, L. S., Zhong, X., Major, E. O., Hogberg, H. T., Hartung, T. & Pardo, C. A., Feb 2022, In: Journal of neurovirology. 28, 1, p. 17-26 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • JC Virus 100%
  • Organoids 93%
  • Progressive Multifocal Leukoencephalopathy 73%
  • Virus Diseases 52%
  • Brain 35%

• Alternative Methods and Citizen Science

  Caloni, F., Fossati, P., Hartung, T., Martino, P. A., Mormino, G., Vitale, A. & de Angelis, I., 2022, In: ALTEX. 39, 1, p. 159-160 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Application of Evidence-Based Methods to Construct Mechanism-Driven Chemical Assessment Frameworks

  Hoffmann, S., Aiassa, E., Angrish, M., Beausoleil, C., Bois, F. Y., Ciccolallo, L., Craig, P. S., de Vries, R. B. M., Dorne, J. L. C. M., Druwe, I. L., Edwards, S. W., Eskes, C., Georgiadis, M., Hartung, T., Kienzler, A., Kristjansson, E. A., Lam, J., Martino, L., Meek, B., Morgan, R. L., & 19 othersMunoz-Guajardo, I., Noyes, P. D., Parmelli, E., Piersma, A., Rooney, A., Sena, E., Sullivan, K., Tarazona, J., Terron, A., Thayer, K., Turner, J., Verbeek, J., Verloo, D., Vinken, M., Watford, S., Whaley, P., Wikoff, D., Willett, K. & Tsaioun, K., 2022, In: ALTEX. 39, 3, p. 499-518 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adverse Outcome Pathways 100%
  • Risk Assessment 50%
  • Education 37%
  • Food Safety 37%
  • Systematic Reviews 22%

• Assessment of the combined effects of chromium and benzene on the rat neuroendocrine and immune systems

  Karaulov, A. V., Smolyagin, A. I., Mikhailova, I. V., Stadnikov, A. A., Ermolina, E. V., Filippova, Y. V., Kuzmicheva, N. A., Vlata, Z., Djordjevic, A. B., Tsitsimpikou, C., Hartung, T., Hernandez, A. F. & Tsatsakis, A., May 1 2022, In: Environmental research. 207, 112096.

  Research output: Contribution to journal › Article › peer-review

  • Neurosecretory Systems 100%
  • immune system 98%
  • Benzene 94%
  • Chromium 91%
  • benzene 70%

• Development of an Evidence-Based Risk Assessment Framework

  Krewski, D., Saunders-Hastings, P., Baan, R. A., Barton-Maclaren, T. S., Browne, P., Chiu, W. A., Gwinn, M., Hartung, T., Kraft, A. D., Lam, J., Lewis, R. J., Sanaa, M., Morgan, R. L., Paoli, G., Rhomberg, L., Rooney, A., Sand, S., Schünemann, H. J., Straif, K., Thayer, K. A., & 1 othersTsaioun, K., 2022, In: ALTEX. 39, 4, p. 667-693 27 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Risk Assessment 100%
  • Consensus Development Conferences 37%
  • Private Sector 29%
  • North America 25%
  • Health 23%

• Engagement of Scientists with the Public and Policymakers to Promote Alternative Methods

  von Aulock, S., Busquet, F., Locke, P., Herrmann, K. & Hartung, T., 2022, In: ALTEX. 39, 4, p. 543-559 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Animal Testing Alternatives 100%
  • Communication 85%
  • Public Opinion 75%
  • Social Media 70%
  • Information Dissemination 67%

• Guidance Document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)

  Pamies, D., Leist, M., Coecke, S., Bowe, G., Allen, D. G., Gstraunthaler, G., Bal-Price, A., Pistollato, F., de Vries, R. B. M., Hogberg, H. T., Hartung, T. & Stacey, G., 2022, In: ALTEX. 39, 1, p. 30-70 41 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cell Culture Techniques 100%
  • Data Accuracy 46%
  • Ethics 44%
  • Documentation 40%
  • Maintenance 30%

• Human organotypic brain model as a tool to study chemical-induced dopaminergic neuronal toxicity

  Pamies, D., Wiersma, D., Katt, M. E., Zhao, L., Burtscher, J., Harris, G., Smirnova, L., Searson, P. C., Hartung, T. & Hogberg, H., Jul 2022, In: Neurobiology of Disease. 169, 105719.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dopaminergic Neurons 100%
  • Oxidopamine 82%
  • Parkinson Disease 80%
  • Oxidative Stress 70%
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 60%

• Probabilistic Risk Assessment - The Keystone for the Future of Toxicology

  Maertens, A., Golden, E., Luechtefeld, T. H., Hoffmann, S., Tsaioun, K. & Hartung, T., 2022, In: ALTEX. 39, 1, p. 3-29 27 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toxicology 100%
  • Uncertainty 94%
  • Risk Assessment 85%
  • Adverse Outcome Pathways 24%
  • Bayes Theorem 17%

• Shell microelectrode arrays (MEAs) for brain organoids

  Huang, Q., Tang, B., Romero, J. C., Yang, Y., Elsayed, S. K., Pahapale, G., Lee, T. J., Pantoja, I. E. M., Han, F., Berlinicke, C., Xiang, T., Solazzo, M., Hartung, T., Qin, Z., Caffo, B. S., Smirnova, L. & Gracias, D. H., Aug 2022, In: Science Advances. 8, 33, eabq5031.

  Research output: Contribution to journal › Article › peer-review

  • Organoids 100%
  • Microelectrodes 85%
  • Brain 37%
  • Polymers 29%
  • Signal-To-Noise Ratio 12%

• The Current Status and Work of Three Rs Centres and Platforms in Europe*

  Neuhaus, W., Reininger-Gutmann, B., Rinner, B., Plasenzotti, R., Wilflingseder, D., De Kock, J., Vanhaecke, T., Rogiers, V., Jírová, D., Kejlová, K., Knudsen, L. E., Nielsen, R. N., Kleuser, B., Kral, V., Thöne-Reineke, C., Hartung, T., Pallocca, G., Rovida, C., Leist, M., Hippenstiel, S., & 50 othersLang, A., Retter, I., Krämer, S., Jedlicka, P., Ameli, K., Fritsche, E., Tigges, J., Kuchovská, E., Buettner, M., Bleich, A., Baumgart, N., Baumgart, J., Meinhardt, M. W., Spanagel, R., Chourbaji, S., Kränzlin, B., Seeger, B., von Köckritz-Blickwede, M., Sánchez-Morgado, J. M., Galligioni, V., Ruiz-Pérez, D., Movia, D., Prina-Mello, A., Ahluwalia, A., Chiono, V., Gutleb, A. C., Schmit, M., van Golen, B., van Weereld, L., Kienhuis, A., van Oort, E., van der Valk, J., Smith, A., Roszak, J., Stępnik, M., Sobańska, Z., Reszka, E., Olsson, I. A. S., Franco, N. H., Sevastre, B., Kandarova, H., Capdevila, S., Johansson, J., Svensk, E., Cederroth, C. R., Sandström, J., Ragan, I., Bubalo, N., Kurreck, J. & Spielmann, H., Nov 2022, In: ATLA Alternatives to Laboratory Animals. 50, 6, p. 381-413 33 p.

  Research output: Contribution to journal › Article › peer-review

  • Anniversaries and Special Events 100%
  • Information Dissemination 92%
  • Ethics 79%
  • Animals 78%
  • Reduction 71%

• The Rise of Three Rs Centres and Platforms in Europe*

  Neuhaus, W., Reininger-Gutmann, B., Rinner, B., Plasenzotti, R., Wilflingseder, D., De Kock, J., Vanhaecke, T., Rogiers, V., Jírová, D., Kejlová, K., Knudsen, L. E., Nielsen, R. N., Kleuser, B., Kral, V., Thöne-Reineke, C., Hartung, T., Pallocca, G., Leist, M., Hippenstiel, S., Lang, A., & 45 othersRetter, I., Krämer, S., Jedlicka, P., Ameli, K., Fritsche, E., Tigges, J., Buettner, M., Bleich, A., Baumgart, N., Baumgart, J., Meinhardt, M. W., Spanagel, R., Chourbaji, S., Kränzlin, B., Seeger, B., von Köckritz-Blickwede, M., Sánchez-Morgado, J. M., Galligioni, V., Ruiz-Pérez, D., Movia, D., Prina-Mello, A., Ahluwalia, A., Chiono, V., Gutleb, A. C., Schmit, M., van Golen, B., van Weereld, L., Kienhuis, A., van Oort, E., van der Valk, J., Smith, A., Roszak, J., Stępnik, M., Sobańska, Z., Olsson, I. A. S., Franco, N. H., Sevastre, B., Kandarova, H., Capdevila, S., Johansson, J., Cederroth, C. R., Sandström, J., Ragan, I., Bubalo, N. & Spielmann, H., Mar 2022, In: ATLA Alternatives to Laboratory Animals. 50, 2, p. 90-120 31 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Food 100%
  • Drug 74%
  • Food Ingredients 65%
  • Reduction 63%
  • Anniversaries and Special Events 59%
• 2021

  Applying evidence-based methods to the development and use of adverse outcome pathways

  de Vries, R. B. M., Angrish, M., Browne, P., Brozek, J., Rooney, A. A., Wikoff, D. S., Whaley, P., Edwards, S. W., Morgan, R. L., Druwe, I. L., Hoffmann, S., Hartung, T., Thayer, K., Avey, M. T., Beverly, B. E. J., Falavigna, M., Gibbons, C., Goyak, K., Kraft, A., Nampo, F., & 7 othersQaseem, A., Sears, M., Singh, J. A., Willett, C., Yost, E. Y., Schünemann, H. & Tsaioun, K., Apr 20 2021, In: ALTEX. 38, 2, p. 336-347 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Adverse Outcome Pathways 100%
  • Education 18%
  • Systematic Reviews 14%
  • Toxicity Tests 13%
  • Automation 12%

• Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry

  Maertens, A., Golden, E. & Hartung, T., Jun 14 2021, In: ACS Sustainable Chemistry and Engineering. 9, 23, p. 7749-7758 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • toxicology 100%
  • Substitution reactions 86%
  • substitution 77%
  • Green 60%
  • Substitution Reaction 55%

• C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly

  Wang, T., Liu, H., Itoh, K., Oh, S., Zhao, L., Murata, D., Sesaki, H., Hartung, T., Na, C. H. & Wang, J., Mar 2 2021, In: Cell Metabolism. 33, 3, p. 531-546.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Frontotemporal Dementia With Motor Neuron Disease 100%
  • Oxidative Phosphorylation 72%
  • Mitochondrial Membranes 71%
  • m-AAA proteases 62%
  • Mitochondria 53%
  3 Scopus citations

• CATMoS: Collaborative acute toxicity modeling suite

  Mansouri, K., Karmaus, A. L., Fitzpatrick, J., Patlewicz, G., Pradeep, P., Alberga, D., Alepee, N., Allen, T. E. H., Allen, D., Alves, V. M., Andrade, C. H., Auernhammer, T. R., Ballabio, D., Bell, S., Benfenati, E., Bhattacharya, S., Bastos, J. V., Boyd, S., Brown, J. B., Capuzzi, S. J., & 82 othersChushak, Y., Ciallella, H., Clark, A. M., Consonni, V., Daga, P. R., Ekins, S., Farag, S., Fedorov, M., Fourches, D., Gadaleta, D., Gao, F., Gearhart, J. M., Goh, G., Goodman, J. M., Grisoni, F., Grulke, C. M., Hartung, T., Hirn, M., Karpov, P., Korotcov, A., Lavado, G. J., Lawless, M., Li, X., Luechtefeld, T., Lunghini, F., Mangiatordi, G. F., Marcou, G., Marsh, D., Martin, T., Mauri, A., Muratov, E. N., Myatt, G. J., Nguyen, D. T., Nicolotti, O., Note, R., Pande, P., Parks, A. K., Peryea, T., Polash, A. H., Rallo, R., Roncaglioni, A., Rowlands, C., Ruiz, P., Russo, D. P., Sayed, A., Sayre, R., Sheils, T., Siegel, C., Silva, A. C., Simeonov, A., Sosnin, S., Southall, N., Strickland, J., Tang, Y., Teppen, B., Tetko, I. V., Thomas, D., Tkachenko, V., Todeschini, R., Toma, C., Tripodi, I., Trisciuzzi, D., Tropsha, A., Varnek, A., Vukovic, K., Wang, Z., Wang, L., Waters, K. M., Wedlake, A. J., Wijeyesakere, S. J., Wilson, D., Xiao, Z., Yang, H., Zahoranszky-Kohalmi, G., Zakharov, A. V., Zhang, F. F., Zhang, Z., Zhao, T., Zhu, H., Zorn, K. M., Casey, W. & Kleinstreuer, N. C., 2021, In: Environmental health perspectives. 129, 4, 047013.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Toxicity 100%
  • Lethal Dose 50 95%
  • Acute Toxicity Oral 69%
  • Silicon Dioxide 37%
  • Acute Toxicity Tests 24%

• Continuing Animal Tests on Cosmetic Ingredients for REACH in the EU

  Knight, J., Rovida, C., Kreiling, R., Zhu, C., Knudsen, M. & Hartung, T., 2021, In: ALTEX. 38, 4, p. 653-668 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Cosmetics 100%
  • Animals 42%
  • Formal Social Control 21%
  • Chemical Databases 16%
  • Safety 12%

• COVID-19 - Prime Time for Microphysiological Systems, as Illustrated for the Brain

  Kang, I., Smirnova, L., Kuhn, J. H., Hogberg, H. T., Kleinstreuer, N. C. & Hartung, T., 2021, In: ALTEX. 38, 4, p. 535-549 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Coronavirus 100%
  • Brain 77%
  • Organoids 69%
  • Infections 50%
  • Bioengineering 34%

• Evaluation of the Global Performance of Eight In Silico Skin Sensitization Models Using Human Data

  Golden, E., Macmillan, D. S., Dameron, G., Kern, P., Hartung, T. & Maertens, A., 2021, In: ALTEX. 38, 1, p. 33-48 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Computer Simulation 100%
  • Skin 58%
  • Local Lymph Node Assay 43%
  • Quantitative Structure-Activity Relationship 36%
  • Datasets 20%
  4 Scopus citations

• Evidence Integration in the Era of Information Flooding—The Advent of the Comprehensive Review

  Hartung, T., Sep 9 2021, In: Frontiers in Public Health. 9, 763828.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Food for Thought … the State of the Scientific Revolution in Toxicology

  Hartung, T. & Tsatsakis, A. M., 2021, In: ALTEX. 38, 3, p. 379-386 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Toxicology 100%

• Gene–environment interactions in developmental neurotoxicity: A case study of synergy between chlorpyrifos and chd8 knockout in human brainspheres

  Modafferi, S., Zhong, X., Kleensang, A., Murata, Y., Fagiani, F., Pamies, D., Hogberg, H. T., Calabrese, V., Lachman, H., Hartung, T. & Smirnova, L., Jul 2021, In: Environmental health perspectives. 129, 7, 077001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chlorpyrifos 100%
  • Neurotoxicity 85%
  • Developmental 82%
  • DNA-Binding Proteins 76%
  • synergy 69%

• Human IPSC-derived model to study myelin disruption

  Chesnut, M., Paschoud, H., Repond, C., Smirnova, L., Hartung, T., Zurich, M. G., Hogberg, H. T. & Pamies, D., Sep 1 2021, In: International journal of molecular sciences. 22, 17, 9473.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • myelin 100%
  • Myelin Sheath 67%
  • Proteins 60%
  • Axons 48%
  • proteins 29%

• Improved strategies to counter the COVID-19 pandemic: Lockdowns vs. primary and community healthcare

  Farsalinos, K., Poulas, K., Kouretas, D., Vantarakis, A., Leotsinidis, M., Kouvelas, D., Docea, A. O., Kostoff, R., Gerotziafas, G. T., Antoniou, M. N., Polosa, R., Barbouni, A., Yiakoumaki, V., Giannouchos, T. V., Bagos, P. G., Lazopoulos, G., Izotov, B. N., Tutelyan, V. A., Aschner, M., Hartung, T., & 4 othersWallace, H. M., Carvalho, F., Domingo, J. L. & Tsatsakis, A., Jan 2021, In: Toxicology Reports. 8, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cope Reaction 100%
  • Community Health Services 96%
  • Pandemics 81%
  • Wave 71%
  • Primary Health Care 60%
  7 Scopus citations

• Mapping Chemical Respiratory Sensitization: How Useful Are Our Current Computational Tools?

  Golden, E., Maertens, M., Hartung, T. & Maertens, A., Feb 15 2021, In: Chemical research in toxicology. 34, 2, p. 473-482 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sensitization 100%
  • Occupational Asthma 65%
  • Environmental Health 57%
  • Adverse Outcome Pathways 52%
  • Occupational Health 51%
  1 Scopus citations

• Methylation and Expression of Mutant FUS in Motor Neurons Differentiated From Induced Pluripotent Stem Cells From ALS Patients

  Hartung, T., Rhein, M., Kalmbach, N., Thau-Habermann, N., Naujock, M., Müschen, L., Frieling, H., Sterneckert, J., Hermann, A., Wegner, F. & Petri, S., Nov 19 2021, In: Frontiers in Cell and Developmental Biology. 9, 774751.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Induced Pluripotent Stem Cells 100%
  • Amyotrophic Lateral Sclerosis 94%
  • Motor Neurons 85%
  • Sarcoma 83%
  • Methylation 80%

• Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model

  Hogberg, H. T., de Cássia da Silveira E Sá, R., Kleensang, A., Bouhifd, M., Cemiloglu Ulker, O., Smirnova, L., Behl, M., Maertens, A., Zhao, L. & Hartung, T., Jan 2021, In: Archives of Toxicology. 95, 1, p. 207-228 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2,2',4,4'-tetrabromodiphenyl ether 100%
  • Flame Retardants 87%
  • Developmental 72%
  • Halogenated Diphenyl Ethers 68%
  • Flame Retardant 61%
  1 Scopus citations

• Pyrogen Testing Revisited on Occasion of the 25^th Anniversary of the Whole Blood Monocyte Activation Test

  Hartung, T., 2021, In: ALTEX. 38, 1, p. 3-19 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pyrogens 100%
  • Anniversaries and Special Events 87%
  • Monocytes 56%
  • Horseshoe Crabs 47%
  • endotoxin binding proteins 38%
  3 Scopus citations

• Similarities and Differences in Gene Expression Networks Between the Breast Cancer Cell Line Michigan Cancer Foundation-7 and Invasive Human Breast Cancer Tissues

  Tran, V., Kim, R., Maertens, M., Hartung, T. & Maertens, A., May 13 2021, In: Frontiers in Artificial Intelligence. 4, 674370.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gene expression 100%
  • Cells 88%
  • Tissue 77%
  • Genes 38%
  • Ligands 13%

• Social injustice in environmental health: A call for fortitude

  Aschner, M., Paoliello, M. M. B., Tsatsakis, A., Bowman, A. B., Dorea, J. G., Hartung, T., Domingo, J. L. & Barbosa, F., Mar 2021, In: Environmental research. 194, 110675.

  Research output: Contribution to journal › Article › peer-review

  • social justice 100%
  • Social Justice 87%
  • Environmental Health 85%
  • environmental health 74%
  • health 47%
  1 Scopus citations

• The Humane Research and Testing Act: Advancing Science by Creating a New Center for Alternatives at the US National Institutes of Health

  Locke, P. A., Singer, M. & Hartung, T., 2021, In: ALTEX. 38, 4, p. 678-680 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • National Institutes of Health (U.S.) 100%
  • Research Personnel 50%
  • Chemical Safety 37%
  • Technology 31%
  • Environmental Health 29%

• Using the Monocyte Activation Test as a Stand-Alone Release Test for Medical Devices

  Brown, J., Clippinger, A. J., Briglia, C. F., Casey, W., Coleman, K., Fritsch, A., Hartung, T., Maouyo, D., Muller, T., Reich, J., Robert, L., Roeder, R., Sanchez, G., Sawyer, A. Y., Solati, S., Tirumalai, R., Zwisler, W. & Allen, D., 2021, In: ALTEX. 38, 1, p. 151-156 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Monocytes 100%
  • Equipment and Supplies 72%
  • Pyrogens 58%
  • pentaerythrityl triacrylate 41%
  • Toxicology 39%
  1 Scopus citations
• 2020

  Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

  Zhong, X., Harris, G., Smirnova, L., Zufferey, V., Sá, R. D. C. D. S. E., Baldino Russo, F., Baleeiro Beltrao Braga, P. C., Chesnut, M., Zurich, M. G., Hogberg, H. T., Hartung, T. & Pamies, D., Feb 21 2020, In: Frontiers in Cellular Neuroscience. 14, 25.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Paroxetine 100%
  • Induced Pluripotent Stem Cells 88%
  • Antidepressive Agents 70%
  • Serotonin Uptake Inhibitors 42%
  • Brain 38%
  7 Scopus citations

• Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development

  Marx, U., Akabane, T., Andersson, T. B., Baker, E., Beilmann, M., Beken, S., Brendler-Schwaab, S., Cirit, M., David, R., Dehne, E. M., Durieux, I., Ewart, L., Fitzpatrick, S. C., Frey, O., Fuchs, F., Griffith, L. G., Hamilton, G. A., Hartung, T., Hoeng, J., Hogberg, H., & 26 othersHughes, D. J., Ingber, D. E., Iskandar, A., Kanamori, T., Kojima, H., Kuehnl, J., Leist, M., Li, B., Loskill, P., Mendrick, D. L., Neumann, T., Pallocca, G., Rusyn, I., Smirnova, L., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tsyb, S., Trapecar, M., Van de Water, B., Van den Eijnden-van Raaij, J., Vulto, P., Watanabe, K., Wolf, A., Zhou, X. & Roth, A., 2020, In: ALTEX. 37, 3, p. 365-394 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Animal Welfare 100%
  • Laboratory Animals 79%
  • Drug Development 65%
  • Industry 42%
  • Technology 30%
  29 Scopus citations

• COVID-19 vaccines: ethical framework concerning human challenge studies

  Calina, D., Hartung, T., Docea, A. O., Spandidos, D. A., Egorov, A. M., Shtilman, M. I., Carvalho, F. & Tsatsakis, A., Dec 2020, In: DARU, Journal of Pharmaceutical Sciences. 28, 2, p. 807-812 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vaccines 100%
  • SARS Virus 73%
  • Safety 56%
  • Pandemics 53%
  • Time 47%
  14 Scopus citations

• Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners

  on behalf of the Metabolomics Quality Assurance, Quality Control Consortium (mQACC), Oct 1 2020, In: Metabolomics. 16, 10, 113.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metabolomics 100%
  • Liquid Chromatography 94%
  • Liquid Chromatography Mass Spectrometry (LCMS) 93%
  • Quality Control 88%
  • Mass Spectrometry 81%
  2 Scopus citations

• EFSA - Johns hopkins food safety symposium 2019

  Libowitz, L., Bloem, M. W., Hugas, M., Tsaioun, K., Url, B. & Hartung, T., Mar 2020, In: ALTEX. 37, 2, p. 312-314 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations

  Maertens, A., Tran, V. H., Maertens, M., Kleensang, A., Luechtefeld, T. H., Hartung, T. & Paller, C. J., Dec 1 2020, In: Scientific reports. 10, 1, 4106.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neoplasm Genes 100%
  • Genes 37%
  • Biological Phenomena 19%
  • Inheritance Patterns 13%
  • Neoplasms 9%
  3 Scopus citations