Research output per year
Research output per year
- 44 results
Search results
-
2025
CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor
Kumar, R., Mendonca, J., Shetty, A., Yang, Y., Owoyemi, O., Wilson, L., Boyapati, K., Topiwala, D., Thomas, N., Nguyen, H., Luo, J., Paller, C. J., Denmeade, S. R., Carducci, M. A. & Kachhap, S. K., Jan 31 2025, In: FASEB Journal. 39, 2, e70342.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Phase I Trial of Intravenous Mistletoe Extract in Advanced Cancer
Paller, C. J., Wang, L., Fu, W., Kumar, R., Durham, J. N., Azad, N. S., Laheru, D. A., Browner, I., Kachhap, S. K., Boyapati, K., Odeny, T., Armstrong, D. K., Meyer, C., Gaillard, S., Brahmer, J. R., Page, I., Wang, H. & Diaz, L. A., Feb 2023, In: Cancer Research Communications. 3, 2, p. 338-346 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications
Kumar, R., Sena, L. A., Denmeade, S. R. & Kachhap, S., May 2023, In: Nature Reviews Urology. 20, 5, p. 265-278 14 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
2022
Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC
Sena, L. A., Kumar, R., Sanin, D. E., Thompson, E. A., Rosen, D. M., Dalrymple, S. L., Antony, L., Yang, Y., Gomes-Alexandre, C., Hicks, J. L., Jones, T., Bowers, K. A., Eskra, J. N., Meyers, J., Gupta, A., Skaist, A., Yegnasubramanian, S., Luo, J., Brennen, W. N. & Kachhap, S. K. & 5 others, , Dec 1 2022, In: Journal of Clinical Investigation. 132, 23, e162396.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular and Clinical Characterization of Patients With Metastatic Castration Resistant Prostate Cancer Achieving Deep Responses to Bipolar Androgen Therapy
Markowski, M. C., Kachhap, S., De Marzo, A. M., Sena, L. A., Luo, J., Denmeade, S. R. & Antonarakis, E. S., Apr 2022, In: Clinical Genitourinary Cancer. 20, 2, p. 97-101 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
HIF1 and ID1 Interplay Confers Adaptive Survival to HIF1α-Inhibition
Geng, H., Ko, H. K., Pittsenbarger, J., Harvey, C. T., Xue, C., Liu, Q., Wiens, S., Kachhap, S. K., Beer, T. M. & Qian, D. Z., Nov 8 2021, In: Frontiers in Cell and Developmental Biology. 9, 724059.Research output: Contribution to journal › Article › peer-review
Open Access -
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer
Kumar, R., Mendonca, J., Owoyemi, O., Boyapati, K., Thomas, N., Kanacharoen, S., Coffey, M., Topiwala, D., Gomes, C., Ozbek, B., Jones, T., Rosen, M., Dong, L., Wiens, S., Brennen, W. N., Isaacs, J. T., Marzo, A. M. D., Markowski, M. C., Antonarakis, E. S. & Qian, D. Z. & 5 others, , Dec 1 2021, In: Cancer Research. 81, 23, p. 5948-5962 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Extreme responses to immune checkpoint blockade following bipolar androgen therapy and enzalutamide in patients with metastatic castration resistant prostate cancer
Markowski, M. C., Shenderov, E., Eisenberger, M., Kachhap, S., Pardoll, D. M., Denmeade, S. R. & Antonarakis, E., Apr 1 2020, In: Prostate. 80, 5, p. 407-411 5 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2019
Erratum to: Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy (Nature Communications, (2018), 9, 1, (4972), 10.1038/s41467-018-07411-7)
Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2019, In: Nature communications. 10, 1, 164.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40
Ignacio, D. N., Mason, K. D., Hackett-Morton, E. C., Albanese, C., Ringer, L., Wagner, W. D., Wang, P. C., Carducci, M. A., Kachhap, S. K., Paller, C. J., Mendonca, J., Li-Ying Chan, L., Lin, B., Hartle, D. K., Green, J. E., Brown, C. A. & Hudson, T. S., Jan 2019, In: Heliyon. 5, 1, e01128.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2018
Interplay between hypoxia and androgen controls a metabolic switch conferring resistance to androgen/AR-targeted therapy
Geng, H., Xue, C., Mendonca, J., Sun, X. X., Liu, Q., Reardon, P. N., Chen, Y., Qian, K., Hua, V., Chen, A., Pan, F., Yuan, J., Dang, S., Beer, T. M., Dai, M. S., Kachhap, S. K. & Qian, D. Z., Dec 1 2018, In: Nature communications. 9, 1, 4972.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2017
Extreme Response to High-dose Testosterone in BRCA2- and ATM-mutated Prostate Cancer
Teply, B. A., Kachhap, S., Eisenberger, M. & Denmeade, S. R., Mar 1 2017, In: European Urology. 71, 3, p. 499 1 p.Research output: Contribution to journal › Letter › peer-review
14 Scopus citations -
The prostate metastasis suppressor gene NDRG1 differentially regulates cell motility and invasion
Sharma, A., Mendonca, J., Ying, J., Kim, H. S., Verdone, J. E., Zarif, J. C., Carducci, M., Hammers, H.-J., Pienta, K. J. & Kachhap, S., Jun 2017, In: Molecular oncology. 11, 6, p. 655-669 15 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2016
C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion
Barakat, D. J., Mendonca, J., Barberi, T., Zhang, J., Kachhap, S. K., Paz-Priel, I. & Friedman, A. D., May 28 2016, In: Cancer Letters. 375, 1, p. 152-161 10 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2015
NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability
Croessmann, S., Wong, H. Y., Zabransky, D. J., Chu, D., Mendonca, J., Sharmaa, A., Mohseni, M., Rosen, D. M., Scharpf, R. B., Cidado, J., Cochran, R. L., Parsons, H. A., Dalton, W. B., Erlanger, B., Button, B., Cravero, K., Kyker-Snowman, K., Beaver, J., Kachhap, S. & Hurley, P. & 2 others, , Sep 15 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 37, p. 11583-11588 6 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Transcriptome sequencing in prostate cancer identifies inter-tumor heterogeneity
Mendonca, J., Sharma, A. & Kachhap, S., May 1 2015, In: Asian Journal of Andrology. 17, 3, p. 435-436 2 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2014
Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer
Paller, C. J., Wissing, M. D., Mendonca, J., Sharma, A., Kim, E., Kim, H. S., Kortenhorst, M. S. Q., Gerber, S., Rosen, M., Shaikh, F., Zahurak, M. L., Rudek, M. A., Hammers, H., Rudin, C. M., Carducci, M. A. & Kachhap, S. K., Oct 1 2014, In: Cancer medicine. 3, 5, p. 1322-1335 14 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Selective inhibitors of nuclear export (SINE) as novel therapeutics for prostate cancer
Mendonca, J., Sharma, A., Kim, H. S., Hammers, H., Meeker, A., Marzo, A. D., Carducci, M., Kauffman, M., Shacham, S. & Kachhap, S., 2014, In: Oncotarget. 5, 15, p. 6102-6112 11 p.Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression
Wissing, M. D., Dadon, T., Kim, E., Piontek, K. B., Shim, J. S., Kaelber, N. S., Liu, J. O., Kachhap, S. K. & Nelkin, B. D., Jul 2014, In: Oncology reports. 32, 1, p. 419-424 6 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2013
Analysis of the genomic response of human prostate cancer cells to histone deacetylase inhibitors
Kortenhorst, M. S. Q., Wissing, M. D., Rodriguez, R., Kachhap, S. K., Jans, J. J. M., van der Groep, P., Verheul, H. M. W., Gupta, A., Aiyetan, P. O., van der Wall, E., Carducci, M. A., Van Diest, P. J. & Marchionni, L., Sep 2013, In: Epigenetics. 8, 9, p. 907-920 14 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells
Wissing, M. D., Mendonca, J., Kim, E., Kim, E., Shim, J. S., Kaelber, N. S., Kant, H., Hammers, H.-J., Commes, T., van Diest, P. J., Liu, J. O. & Kachhap, S. K., May 2013, In: Cancer Biology and Therapy. 14, 5, p. 401-410 10 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Repurposing itraconazole as a treatment for advanced prostate cancer: A noncomparative randomized phase ii trial in men with metastatic castration-resistant prostate cancer
Antonarakis, E. S., Heath, E. I., Smith, D. C., Rathkopf, D., Blackford, A. L., Danila, D. C., King, S., Frost, A., Seun Ajiboye, A., Zhao, M., Mendonca, J., Kachhap, S. K., Rudek, M. A. & Carducci, M. A., 2013, In: Oncologist. 18, 2, p. 163-173 11 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
Screening assay for blood vessel maturation inhibitors
Fu, C., van der Zwan, A., Gerber, S., Van Den Berg, S., No, E., C.H.Wang, W., Sheibani, N., Carducci, M. A., Kachhap, S. & Hammers, H. J., Aug 23 2013, In: Biochemical and Biophysical Research Communications. 438, 2, p. 364-369 6 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Targeting prostate cancer cell lines with polo-like kinase 1 inhibitors as a single agent and in combination with histone deacetylase inhibitors
Wissing, M. D., Mendonca, J., Kortenhorst, M. S. Q., Kaelber, N. S., Gonzalez, M., Kim, E., Hammers, H., Van Diest, P. J., Carducci, M. A. & Kachhap, S. K., Oct 1 2013, In: FASEB Journal. 27, 10, p. 4279-4293 15 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment
Isaacs, J. T., Antony, L., Dalrymple, S. L., Brennen, W. N., Gerber, S., Hammers, H., Wissing, M., Kachhap, S., Luo, J., Xing, L., Bjork, P., Olsson, A., Bjork, A. & Leanderson, T., Jan 15 2013, In: Cancer Research. 73, 4, p. 1386-1399 14 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
2012
Metastasis: Genetics, mechanism, and diagnostic and therapeutic strategies
Gunduz, M., Gunduz, E., Beder, L., Pehlivan, D., Hatipoglu, O. F., Kachhap, S. & Grenman, R., 2012, In: Journal of Oncology. 390835.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Scopus citations -
2011
Cigarette smoke and cancer
Kachhap, S., Keshamouni, V. G., Qian, D. Z. & Chatterjee, A., 2011, In: Journal of Oncology. 172678.Research output: Contribution to journal › Editorial › peer-review
Open Access2 Scopus citations -
Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth
Lin, J., Haffner, M. C., Zhang, Y., Lee, B. H., Brennen, W. N., Britton, J., Kachhap, S. K., Shim, J. S., Liu, J. O., Nelson, W. G., Yegnasubramanian, S. & Carducci, M. A., Mar 1 2011, In: Prostate. 71, 4, p. 333-343 11 p.Research output: Contribution to journal › Article › peer-review
Open Access121 Scopus citations -
2010
Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor
Kachhap, S. K., Rosmus, N., Collis, S. J., Kortenhorst, M. S. Q., Wissing, M. D., Hedayati, M., Shabbeer, S., Mendonca, J., Deangelis, J., Marchionni, L., Lin, J., Höti, N., Nortier, J. W. R., Deweese, T. L., Hammers, H. & Carducci, M. A., 2010, In: PloS one. 5, 6, e11208.Research output: Contribution to journal › Article › peer-review
Open Access109 Scopus citations -
2009
Fenugreek a naturally occurring edible spice as an anticancer agent
Shabbeer, S., Sobolewski, M., Anchoori, R. K., Kachhap, S., Davidson, N., Carducci, M. A. & Khan, S. R., Feb 2009, In: Cancer Biology and Therapy. 8, 3, p. 272-278 7 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
2008
A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors
Kortenhorst, M. S. Q., Zahurak, M., Shabbeer, S., Kachhap, S., Galloway, N., Parmigiani, G., Verheul, H. M. W. & Carducci, M. A., Nov 1 2008, In: Clinical Cancer Research. 14, 21, p. 6886-6894 9 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2007
Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck
Zhou, S., Kachhap, S., Sun, W., Wu, G., Chuang, A., Poeta, L., Grumbine, L., Mithani, S. K., Chatterjee, A., Koch, W., Westra, W. H., Maitra, A., Glazer, C., Carducci, M., Sidransky, D., McFate, T., Verma, A. & Califano, J. A., May 1 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 18, p. 7540-7545 6 p.Research output: Contribution to journal › Article › peer-review
Open Access151 Scopus citations -
Multiple molecular pathways explain the anti-proliferative effect of valproic acid on prostate cancer cells in vitro and in vivo
Shabbeer, S., Kortenhorst, M. S. Q., Kachhap, S., Galloway, N., Rodriguez, R. & Carducci, M. A., Jul 1 2007, In: Prostate. 67, 10, p. 1099-1110 12 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
The N-Myc down regulated gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin
Kachhap, S. K., Faith, D., Qian, D. Z., Shabbeer, S., Galloway, N. L., Pili, R., Denmeade, S. R., DeMarzo, A. M. & Carducci, M. A., Sep 5 2007, In: PloS one. 2, 9, e844.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
2006
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α
Qian, D. Z., Kachhap, S. K., Collis, S. J., Verheul, H. M. W., Carducci, M. A., Atadja, P. & Pili, R., Sep 1 2006, In: Cancer Research. 66, 17, p. 8814-8821 8 p.Research output: Contribution to journal › Article › peer-review
252 Scopus citations -
2004
Blocking angiogenesis and histone deacetylases in prostate and breast cancer bearing mice
Qian, D. Z., Wang, X., Kachhap, S. K., Kato, Y., Wei, Y., Zhang, L. & Atadja, P., Oct 2004, In: Cancer Biology and Therapy. 3, 10, p. 297-928 632 p.Research output: Contribution to journal › Comment/debate › peer-review
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Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
Kachhap, S. & Singh, K. K., Dec 1 2004, In: Molecular Cancer. 3, 32.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
The histone deacetylase inhibitor NVP-LAQ824 Inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584
Qian, D. Z., Wang, X., Kachhap, S. K., Kato, Y., Wei, Y., Zhang, L., Atadja, P. & Pili, R., Sep 15 2004, In: Cancer Research. 64, 18, p. 6626-6634 9 p.Research output: Contribution to journal › Article › peer-review
199 Scopus citations -
2003
Mitochondrial impairment in p53-deficient human cancer cells
Zhou, S., Kachhap, S. & Singh, K. K., May 2003, In: Mutagenesis. 18, 3, p. 287-292 6 p.Research output: Contribution to journal › Article › peer-review
96 Scopus citations -
2002
Nuclear genes involved in mitochondria-to-nucleus communication in breast cancer cells
Delsite, R., Kachhap, S., Anbazhagan, R., Gabrielson, E. & Singh, K. K., Nov 12 2002, In: Molecular Cancer. 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
2001
Effect of ω-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line
Kachhap, S. K., Dange, P. P., Santani, R. H., Sawant, S. S. & Ghosh, S. N., 2001, In: Cancer Biotherapy and Radiopharmaceuticals. 16, 3, p. 257-263 7 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Implication of BRCA1 gene in breast cancer
Kachhap, S. K. & Ghosh, S. N., 2001, In: Indian journal of experimental biology. 39, 5, p. 391-400 10 p.Research output: Contribution to journal › Review article › peer-review
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Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line
Kachhap, S. K., Vetale, S. P., Dange, P. & Ghosh, S. N., 2001, In: Cell biology international. 25, 6, p. 547-551 5 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2000
Effect of ω-6 polyunsaturated fatty acid (linoleic acid) on BRCA1 gene expression in MCF-7 cell line
Kachhap, S. K., Dange, P. & Nath Ghosh, S., Jun 30 2000, In: Cancer Letters. 154, 2, p. 115-120 6 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations