Research output per year
Research output per year
- 1 - 50 out of 61 results
Search results
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2023
CTRP13 ablation improves systemic glucose and lipid metabolism
Chen, F., Sarver, D. C., Saqib, M., Zhou, M., Aja, S., Seldin, M. M. & Wong, G. W., Dec 2023, In: Molecular Metabolism. 78, 101824.Research output: Contribution to journal › Article › peer-review
Open Access -
Dysregulated systemic metabolism in a Down syndrome mouse model
Sarver, D. C., Xu, C., Velez, L. M., Aja, S., Jaffe, A. E., Seldin, M. M., Reeves, R. H. & Wong, G. W., Feb 2023, In: Molecular Metabolism. 68, 101666.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypermetabolism in mice carrying a near-complete human chromosome 21
Sarver, D. C., Xu, C., Rodriguez, S., Aja, S., Jaffe, A. E., Gao, F. J., Delannoy, M., Periasamy, M., Kazuki, Y., Oshimura, M., Reeves, R. H. & Wong, G. W., 2023, In: eLife. 12, e86023.Research output: Contribution to journal › Article › peer-review
Open Access -
Kynurenine pathway metabolism evolves with development of preclinical and scleroderma-associated pulmonary arterial hypertension
Simpson, C. E., Ambade, A. S., Harlan, R., Roux, A., Aja, S., Graham, D., Shah, A. A., Hummers, L. K., Hemnes, A. R., Leopold, J. A., Horn, E. M., Berman-Rosenzweig, E. S., Grunig, G., Aldred, M. A., Barnard, J., Comhair, S. A. A., Tang, W. H. W., Griffiths, M., Rischard, F., Frantz, R. P., & 6 others, Nov 2023, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 325, 5, p. L617-L627Research output: Contribution to journal › Article › peer-review
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Metabolic profiling of in vivo right ventricular function and exercise performance in pulmonary arterial hypertension
Simpson, C. E., Coursen, J., Hsu, S., Gough, E. K., Harlan, R., Roux, A., Aja, S., Graham, D., Kauffman, M., Suresh, K., Tedford, R. J., Kolb, T. M., Mathai, S. C., Hassoun, P. M. & Damico, R. L., Jun 1 2023, In: American journal of physiology. Lung cellular and molecular physiology. 324, 6, p. L836-L848Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial β-oxidation of adiposederived fatty acids by osteoblasts fuels parathyroid hormone-induced bone formation
Alekos, N. S., Kushwaha, P., Kim, S. P., Li, Z., Abood, A., Dirckx, N., Aja, S., Kodama, J., Garcia-Diaz, J. G., Otsuru, S., Rendina-Ruedy, E., Wolfgang, M. J. & Riddle, R. C., Mar 22 2023, In: JCI Insight. 8, 6, e165604.Research output: Contribution to journal › Article › peer-review
Open Access -
Peroxisome proliferator activated receptor-γ in osteoblasts controls bone formation and fat mass by regulating sclerostin expression
Kim, S. P., Seward, A. H., Garcia-Diaz, J., Alekos, N., Gould, N. R., Aja, S., Stains, J. P., Wolfgang, M. J. & Riddle, R. C., Jul 21 2023, In: iScience. 26, 7, 106999.Research output: Contribution to journal › Article › peer-review
Open Access -
Serendipitous Discovery of T Cell–Produced KLK1b22 as a Regulator of Systemic Metabolism
Arwood, M. L., Sun, I. H., Patel, C. H., Sun, I. M., Oh, M. H., Bettencourt, I. A., Claiborne, M. D., Chan-Li, Y., Zhao, L., Waickman, A. T., Mavrothalassitis, O., Wen, J., Aja, S. & Powell, J. D., Jun 1 2023, In: ImmunoHorizons. 7, 6, p. 493-507 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
CTRP11 contributes modestly to systemic metabolism and energy balance
Sarver, D. C., Xu, C., Carreno, D., Arking, A., Terrillion, C. E., Aja, S. & Wong, G. W., Jun 2022, In: FASEB Journal. 36, 6, e22347.Research output: Contribution to journal › Article › peer-review
Open Access -
CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding
Sarver, D. C., Xu, C., Aja, S. & Wong, G. W., 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 322, 6, p. E480-E493Research output: Contribution to journal › Article › peer-review
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Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons
Alexandris, A. S., Ryu, J., Rajbhandari, L., Harlan, R., McKenney, J., Wang, Y., Aja, S., Graham, D., Venkatesan, A. & Koliatsos, V. E., Sep 2022, In: Neurobiology of Disease. 171, 105808.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
Wang, Q., Hernández-Ochoa, E. O., Viswanathan, M. C., Blum, I. D., Do, D. C., Granger, J. M., Murphy, K. R., Wei, A. C., Aja, S., Liu, N., Antonescu, C. M., Florea, L. D., Talbot, C. C., Mohr, D., Wagner, K. R., Regot, S., Lovering, R. M., Gao, P., Bianchet, M. A., Wu, M. N., & 4 others, Dec 1 2021, In: Nature communications. 12, 1, 3175.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Loss of CTRP4 alters adiposity and food intake behaviors in obese mice
Sarver, D. C., Stewart, A. N., Rodriguez, S., Little, H. C., Aja, S. & Wong, G. W., Dec 15 2020, In: American Journal of Physiology - Endocrinology and Metabolism. 319, 6, p. E1084-E1100Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice
Yoo, S., Cha, D., Kim, S., Jiang, L., Cooke, P., Adebesin, M., Wolfe, A., Riddle, R., Aja, S. & Blackshaw, S., Oct 1 2020, In: Glia. 68, 10, p. 1987-2000 14 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2019
FAM19A1, a brain-enriched and metabolically responsive neurokine, regulates food intake patterns and mouse behaviors
Lei, X., Liu, L., Terrillion, C. E., Karuppagounder, S. S., Cisternas, P., Lay, M., Martinelli, D. C., Aja, S., Dong, X., Pletnikov, M. V. & Wong, G. W., Dec 2019, In: FASEB Journal. 33, 12, p. 14734-14747 14 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
MeCP2 deficiency disrupts kainate-induced presynaptic plasticity in the mossy fiber projections in the hippocampus
Bertoldi, M. L., Zalosnik, M. I., Fabio, M. C., Aja, S., Roth, G. A., Ronnett, G. V. & Degano, A. L., May 14 2019, In: Frontiers in Cellular Neuroscience. 13, 286.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2018
DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders
Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V. L., Dawson, T. M., Aja, S., Sesaki, H. & Pletnikov, M. V., Dec 1 2018, In: Translational psychiatry. 8, 1, 76.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2017
Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance
Lopez, P. H. H., Aja, S., Aoki, K., Seldin, M. M., Lei, X., V Ronnett, G., Wong, G. W. & Schnaar, R. L., 2017, In: Glycobiology. 27, 1, p. 129-139 11 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes
Kim, S. P., Frey, J. L., Li, Z., Kushwaha, P., Zoch, M. L., Tomlinson, R. E., Da, H., Aja, S., Noh, H. L., Kim, J. K., Hussain, M., Thorek, D., Wolfgang, M. J. & Riddle, R. C., Dec 26 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11238-E11247Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
2016
D-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway
Jeon, Y., Aja, S., Ronnett, G. V. & Kim, E. K., Feb 19 2016, In: Biochemical and Biophysical Research Communications. 470, 4, p. 818-823 6 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
Slocum, S. L., Skoko, J. J., Wakabayashi, N., Aja, S., Yamamoto, M., Kensler, T. W. & Chartoumpekis, D. V., Feb 1 2016, In: Archives of Biochemistry and Biophysics. 591, p. 57-65 9 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Loss of Adipose Fatty Acid Oxidation Does Not Potentiate Obesity at Thermoneutrality
Lee, J., Choi, J., Aja, S., Scafidi, S. & Wolfgang, M. J., Feb 16 2016, In: Cell Reports. 14, 6, p. 1308-1316 9 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2015
Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast
Frey, J. L., Li, Z., Ellis, J. M., Zhang, Q., Farber, C. R., Aja, S., Wolfgang, M. J., Clemens, T. L. & Riddle, R. C., 2015, In: Molecular and cellular biology. 35, 11, p. 1979-1991 13 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
2014
Anaplerotic triheptanoin diet enhances mitochondrial substrate use to remodel the metabolome and improve lifespan, motor function, and sociability in MeCP2-null mice
Park, M. J., Aja, S., Li, Q., Degano, A. L., Penati, J., Zhuo, J., Roe, C. R. & Ronnett, G. V., 2014, In: PloS one. 9, 10, e0109527.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice
Lee, D. A., Yoo, S., Pak, T., Salvatierra, J., Velarde, E., Aja, S. & Blackshaw, S., 2014, In: Frontiers in Neuroscience. 8 JUN, Article 157.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations -
Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation
McFadden, J. W., Aja, S., Li, Q., Bandaru, V. V. R., Kim, E. K., Haughey, N. J., Kuhajda, F. P. & Ronnett, G. V., Dec 26 2014, In: PloS one. 9, 12, e115642.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Targeted deletion of C1q/TNF-related protein 9 increases food intake, decreases insulin sensitivity, and promotes hepatic steatosis in mice
Wei, Z., Lei, X., Petersen, P. S., Aja, S. & Wong, G. W., Apr 1 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 7, p. E779-E790Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
2013
CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism
Peterson, J. M., Seldin, M. M., Wei, Z., Aja, S. & Wong, G. W., Aug 1 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 305, 3, p. G214-G224Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction
Peterson, J. M., Wei, Z., Seldin, M. M., Byerly, M. S., Aja, S. & Wong, G. W., Sep 1 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 305, 5, p. R522-R533Research output: Contribution to journal › Article › peer-review
Open Access79 Scopus citations -
Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression
Byerly, M. S., Al Salayta, M., Swanson, R. D., Kwon, K., Peterson, J. M., Wei, Z., Aja, S., Moran, T. H., Blackshaw, S. & Wong, G. W., Apr 2013, In: European Journal of Neuroscience. 37, 7, p. 1033-1047 15 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite
Byerly, M. S., Swanson, R. D., Semsarzadeh, N. N., McCulloh, P. S., Kwon, K., Aja, S., Moran, T. H., William Wong, G. & Blackshaw, S., Jun 15 2013, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 304, 12, p. R1085-R1095Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2012
A novel obesity model: Synphilin-1-induced hyperphagia and obesity in mice
Li, X., Tamashiro, K. L. K., Liu, Z., Bello, N. T., Wang, X., Aja, S., Bi, S., Ladenheim, E. E., Ross, C. A., Moran, T. H. & Smith, W. W., Sep 2012, In: International Journal of Obesity. 36, 9, p. 1215-1221 7 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition
Peterson, J. M., Aja, S., Wei, Z. & Wong, G. W., Jan 6 2012, In: Journal of Biological Chemistry. 287, 2, p. 1576-1587 12 p.Research output: Contribution to journal › Article › peer-review
Open Access104 Scopus citations -
Metabolic Consequences of High-Fat Diet Are Attenuated by Suppression of HIF-1α
Shin, M. K., Drager, L. F., Yao, Q., Bevans-Fonti, S., Yoo, D. Y., Jun, J. C., Aja, S., Bhanot, S. & Polotsky, V. Y., Oct 1 2012, In: PloS one. 7, 10, e46562.Research output: Contribution to journal › Article › peer-review
Open Access40 Scopus citations -
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K. L. K., Aja, S., & 10 others, Jan 2012, In: Nature medicine. 18, 1, p. 153-158 6 p.Research output: Contribution to journal › Article › peer-review
Open Access235 Scopus citations -
Physiological oxygen level is critical for modeling neuronal metabolism in vitro
Zhu, J., Aja, S., Kim, E. K., Park, M. J., Ramamurthy, S., Jia, J., Hu, X., Geng, P. & Ronnett, G. V., Feb 2012, In: Journal of neuroscience research. 90, 2, p. 422-434 13 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Lee, D. A., Bedont, J. L., Pak, T., Wang, H., Song, J., Miranda-Angulo, A., Takiar, V., Charubhumi, V., Balordi, F., Takebayashi, H., Aja, S., Ford, E., Fishell, G. & Blackshaw, S., May 2012, In: Nature neuroscience. 15, 5, p. 700-702 3 p.Research output: Contribution to journal › Article › peer-review
Open Access290 Scopus citations -
The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal
Gietzen, D. W. & Aja, S. M., Oct 2012, In: Molecular Neurobiology. 46, 2, p. 332-348 17 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2011
Knockdown of NPY expression in the dorsomedial hypothalamus promotes development of brown adipocytes and prevents diet-induced obesity
Chao, P. T., Yang, L., Aja, S., Moran, T. H. & Bi, S., May 4 2011, In: Cell Metabolism. 13, 5, p. 573-583 11 p.Research output: Contribution to journal › Article › peer-review
Open Access142 Scopus citations -
Pharmacological glycerol-3-phosphate acyltransferase inhibition decreases food intake and adiposity and increases insulin sensitivity in diet-induced obesity
Kuhajda, F. P., Aja, S., Tu, Y., Han, W. F., Medghalchi, S. M., El Meskini, R., Landree, L. E., Peterson, J. M., Daniels, K., Wong, K., Wydysh, E. A., Townsend, C. A. & Ronnett, G. V., Jul 2011, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 301, 1, p. R116-R130Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells
Zhang, Z., Wakabayashi, N., Wakabayashi, J., Tamura, Y., Song, W. J., Sereda, S., Clerc, P., Polster, B. M., Aja, S. M., Pletnikov, M. V., Kensler, T. W., Shirihai, O. S., Iijima, M., Hussain, M. A. & Sesaki, H., Jul 1 2011, In: Molecular biology of the cell. 22, 13, p. 2235-2245 11 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
2010
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
Chiang, P. M., Ling, J., Jeong, Y. H., Price, D. L., Aja, S. M. & Wong, P. C., Sep 14 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16320-16324 5 p.Research output: Contribution to journal › Article › peer-review
188 Scopus citations -
Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Fulzele, K., Riddle, R. C., DiGirolamo, D. J., Cao, X., Wan, C., Chen, D., Faugere, M. C., Aja, S., Hussain, M. A., Brüning, J. C. & Clemens, T. L., Jul 2010, In: Cell. 142, 2, p. 309-319 11 p.Research output: Contribution to journal › Article › peer-review
Open Access528 Scopus citations -
2009
AMPK in the brain: Its roles in energy balance and neuroprotection
Ronnett, G. V., Ramamurthy, S., Kleman, A. M., Landree, L. E. & Aja, S., May 2009, In: Journal of Neurochemistry. 109, SUPPL. 1, p. 17-23 7 p.Research output: Contribution to journal › Article › peer-review
Open Access203 Scopus citations -
Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity
Davis, L. M., Michaelides, M., Cheskin, L. J., Moran, T. H., Aja, S., Watkins, P. A., Pei, Z., Contoreggi, C., McCullough, K., Hope, B., Wang, G. J., Volkow, N. D. & Thanos, P. K., Feb 2009, In: Neuroendocrinology. 89, 2, p. 152-162 11 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide
Shin, S., Wakabayashi, J., Yates, M. S., Wakabayashi, N., Dolan, P. M., Aja, S., Liby, K. T., Sporn, M. B., Yamamoto, M. & Kensler, T. W., Oct 12 2009, In: European Journal of Pharmacology. 620, 1-3, p. 138-144 7 p.Research output: Contribution to journal › Article › peer-review
Open Access192 Scopus citations -
2008
Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats
Mansouri, A., Aja, S., Moran, T. H., Ronnett, G., Kuhajda, F. P., Arnold, M., Geary, N., Langhans, W. & Leonhardt, M., Sep 2008, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 3, p. R799-R805Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Pharmacological stimulation of brain carnitine palmitoyl-transferase-1 decreases food intake and body weight
Aja, S., Landree, L. E., Kleman, A. M., Medghalchi, S. M., Vadlamudi, A., McFadden, J. M., Aplasca, A., Hyun, J., Plummer, E., Daniels, K., Kemm, M., Townsend, C. A., Thupari, J. N., Kuhajda, F. P., Moran, T. H. & Ronnett, G. V., Feb 2008, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 2, p. R352-R361Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Physiological glucose is critical for optimized neuronal viability and AMPK responsiveness in vitro
Kleman, A. M., Yuan, J. Y., Aja, S., Ronnett, G. V. & Landree, L. E., Jan 30 2008, In: Journal of Neuroscience Methods. 167, 2, p. 292-301 10 p.Research output: Contribution to journal › Article › peer-review
42 Scopus citations -
2007
Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake
Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., Ladenheim, E. E., Ronnett, G. V., Tu, Y. J., Birnbaum, M. J., Lopaschuk, G. D. & Moran, T. H., Oct 30 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 44, p. 17358-17363 6 p.Research output: Contribution to journal › Article › peer-review
166 Scopus citations