Shri Bhat

2023

Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding

Egleston, M., Dong, L., Howlader, A. H., Bhat, S., Orris, B., Bianchet, M. A., Greenberg, M. M. & Stivers, J. T., Oct 20 2023, In: ACS chemical biology. 18, 10, p. 2200-2210 11 p.

Research output: Contribution to journal › Article › peer-review

Guanine-containing ssDNA and RNA induce dimeric and tetrameric structural forms of SAMHD

Orris, B., Sung, M. W., Bhat, S., Xu, Y., Huynh, K. W., Han, S., Johnson, D. C., Bosbach, B., Shields, D. J. & Stivers, J. T., Dec 11 2023, In: Nucleic acids research. 51, 22, p. 12443-12458 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a

Vinson, D. A., Stephens, K. E., O’Meally, R. N., Bhat, S., Dancy, B. C. R., Cole, R. N., Yegnasubramanian, S. & Taverna, S. D., Dec 2022, In: Epigenetics and Chromatin. 15, 1, 36.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2

Rodriguez, G., Orris, B., Majumdar, A., Bhat, S. & Stivers, J. T., Feb 2020, In: DNA Repair. 86, 102764.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2019

Rapamycin-inspired macrocycles with new target specificity

Guo, Z., Hong, S. Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., Ullman, B. R., Tse, C. M., Tarmakova, Z., Schiene-Fischer, C., Fischer, G., Coe, I., Paavilainen, V. O., Sun, Z. & Liu, J. O., Mar 1 2019, In: Nature Chemistry. 11, 3, p. 254-263 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

2018

Hydrazide Mimics for Protein Lysine Acylation to Assess Nucleosome Dynamics and Deubiquitinase Action

Bhat, S., Hwang, Y., Gibson, M. D., Morgan, M. T., Taverna, S. D., Zhao, Y., Wolberger, C., Poirier, M. G. & Cole, P. A., Aug 1 2018, In: Journal of the American Chemical Society. 140, 30, p. 9478-9485 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

Bauer, L., Ferla, S., Head, S. A., Bhat, S., Pasunooti, K. K., Shi, W. Q., Albulescu, L., Liu, J. O., Brancale, A., van Kuppeveld, F. J. M. & Strating, J. R. P. M., Aug 2018, In: Antiviral Research. 156, p. 55-63 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2013

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

Zhang, P., Yang, X., Zhang, F., Gabelli, S. B., Wang, R., Zhang, Y., Bhat, S., Chen, X., Furlani, M., Amzel, L. M., Liu, J. O. & Ma, D., May 1 2013, In: Bioorganic and Medicinal Chemistry. 21, 9, p. 2600-2617 18 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells

Zhang, F., Bhat, S., Gabelli, S. B., Chen, X., Miller, M. S., Nacev, B. A., Cheng, Y. L., Meyers, D. J., Tenney, K., Shim, J. S., Crews, P., Amzel, L. M., Ma, D. & Liu, J. O., May 23 2013, In: Journal of medicinal chemistry. 56, 10, p. 3996-4016 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Tricyclic thiazoles are a new class of angiogenesis inhibitors

Bhat, S., Shim, J. S. & Liu, J. O., May 1 2013, In: Bioorganic and Medicinal Chemistry Letters. 23, 9, p. 2733-2737 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2012

Analogs of N′-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl) methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases

Bhat, S., Olaleye, O., Meyer, K. J., Shi, W., Zhang, Y. & Liu, J. O., Jul 15 2012, In: Bioorganic and Medicinal Chemistry. 20, 14, p. 4507-4513 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

Xing, S., Bhat, S., Shroff, N. S., Zhang, H., Lopez, J. A., Margolick, J. B., Liu, J. O. & Siliciano, R. F., Feb 2012, In: Journal of Antimicrobial Chemotherapy. 67, 2, p. 398-403 6 p., dkr496.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

Krátký, M., Vinová, J., Novotná, E., Mandíková, J., Wsól, V., Trejtnar, F., Ulmann, V., Stolaíková, J., Fernandes, S., Bhat, S. & Liu, J. O., Sep 2012, In: Tuberculosis. 92, 5, p. 434-439 6 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Substituted oxines inhibit endothelial cell proliferation and angiogenesis

Bhat, S., Shim, J. S., Zhang, F., Chong, C. R. & Liu, J. O., Apr 21 2012, In: Organic and Biomolecular Chemistry. 10, 15, p. 2979-2992 14 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

2011

A simple and efficient route to the FKBP-binding domain from rapamycin

Li, W., Bhat, S. & Liu, J. O., Sep 28 2011, In: Tetrahedron Letters. 52, 39, p. 5070-5072 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis

Olaleye, O., Raghunand, T. R., Bhat, S., Chong, C., Gu, P., Zhou, J., Zhang, Y., Bishai, W. R. & Liu, J. O., Dec 2011, In: Tuberculosis. 91, SUPPL. 1, p. S61-S65

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion

Chamni, S., He, Q. L., Dang, Y., Bhat, S., Liu, J. O. & Romo, D., Nov 18 2011, In: ACS chemical biology. 6, 11, p. 1175-1181 7 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

Xing, S., Bullen, C. K., Shroff, N. S., Shan, L., Yang, H. C., Manucci, J. L., Bhat, S., Zhang, H., Margolick, J. B., Quinn, T. C., Margolis, D. M., Siliciano, J. D. & Siliciano, R. F., Jun 2011, In: Journal of virology. 85, 12, p. 6060-6064 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

147 Scopus citations

Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B

Dang, Y., Schneider-Poetsch, T., Eyler, D. E., Jewett, J. C., Bhat, S., Rawal, V. H., Green, R. & Liu, J. O., Aug 2011, In: RNA. 17, 8, p. 1578-1588 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Optimization of the potency and pharmacokinetic properties of a macrocyclic ghrelin receptor agonist (Part I): Development of ulimorelin (TZP-101) from Hit to Clinic

Hoveyda, H. R., Marsault, E., Gagnon, R., Mathieu, A. P., Vézina, M., Landry, A., Wang, Z., Benakli, K., Beaubien, S., Saint-Louis, C., Brassard, M., Pinault, J. F., Ouellet, L., Bhat, S., Ramaseshan, M., Peng, X., Foucher, L., Beauchemin, S., Bhérer, P., Veber, D. F., & 2 othersPeterson, M. L. & Fraser, G. L., Dec 22 2011, In: Journal of medicinal chemistry. 54, 24, p. 8305-8320 16 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

XPB, a subunit of TFIIH, is a target of the natural product triptolide

Titov, D. V., Gilman, B., He, Q. L., Bhat, S., Low, W. K., Dang, Y., Smeaton, M., Demain, A. L., Miller, P. S., Kugel, J. F., Goodrich, J. A. & Liu, J. O., Mar 2011, In: Nature chemical biology. 7, 3, p. 182-188 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

2010

Effect of nitroxoline on angiogenesis and growth of human bladder cancer

Shim, J. S., Matsui, Y., Bhat, S., Nacev, B. A., Xu, J., Bhang, H. E. C., Dhara, S., Han, K. C., Chong, C. R., Pomper, M. G., So, A. & Liu, J. O., Dec 15 2010, In: Journal of the National Cancer Institute. 102, 24, p. 1855-1873 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

70 Scopus citations

Impact of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole

Shi, W., Nacev, B. A., Bhat, S. & Liu, J. O., 2010, In: ACS Medicinal Chemistry Letters. 1, 4, p. 155-159 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

Schneider-Poetsch, T., Ju, J., Eyler, D. E., Dang, Y., Bhat, S., Merrick, W. C., Green, R., Shen, B. & Liu, J. O., Mar 2010, In: Nature chemical biology. 6, 3, p. 209-217 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

464 Scopus citations

Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets

Olaleye, O., Raghunand, T. R., Bhat, S., He, J., Tyagi, S., Lamichhane, G., Gu, P., Zhou, J., Zhang, Y., Grosset, J., Bishai, W. R. & Liu, J. O., Jan 29 2010, In: Chemistry and Biology. 17, 1, p. 86-97 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

2009

Fumagillin and Fumarranol Interact with P. falciparum Methionine Aminopeptidase 2 and Inhibit Malaria Parasite Growth In Vitro and In Vivo

Chen, X., Xie, S., Bhat, S., Kumar, N., Shapiro, T. A. & Liu, J. O., Feb 27 2009, In: Chemistry and Biology. 16, 2, p. 193-202 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

High throughput solid phase parallel synthesis of macrocyclic peptidomimetics.

Marsault, E., Hoveyda, H. R., Peterson, M. L., Gagnon, R., Vézina, M., Pinault, J. F., Landry, A., Saint-Louis, C., Ouellet, L. G., Beauchemin, S., Benakli, K., Beaubien, S., Brassard, M., Wang, Z., Champagne, M., Galaud, F., Fortin, N., Fortin, D., Plourde, V., Ramaseshan, M., & 10 othersBhat, S., Bilodeau, F., Lonergan, D., Lan, R., Li, S., Berthiaume, G., Foucher, L., Peng, X., Dory, Y. & Deslongchamps, P., 2009, In: Advances in experimental medicine and biology. 611, p. 15-16 2 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

It Takes Two Binding Sites for Calcineurin and NFAT to Tango

Liu, J. O., Nacev, B. A., Xu, J. & Bhat, S., Mar 27 2009, In: Molecular cell. 33, 6, p. 676-678 3 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

6 Scopus citations

2008

Efficient parallel synthesis of macrocyclic peptidomimetics

Marsault, E., Hoveyda, H. R., Gagnon, R., Peterson, M. L., Vézina, M., Saint-Louis, C., Landry, A., Pinault, J. F., Ouellet, L., Beauchemin, S., Beaubien, S., Mathieu, A., Benakli, K., Wang, Z., Brassard, M., Lonergan, D., Bilodeau, F., Ramaseshan, M., Fortin, N., Lan, R., & 20 othersLi, S., Galaud, F., Plourde, V., Champagne, M., Doucet, A., Bhérer, P., Gauthier, M., Olsen, G., Villeneuve, G., Bhat, S., Foucher, L., Fortin, D., Peng, X., Bernard, S., Drouin, A., Déziel, R., Berthiaume, G., Dory, Y. L., Fraser, G. L. & Deslongchamps, P., Aug 15 2008, In: Bioorganic and Medicinal Chemistry Letters. 18, 16, p. 4731-4735 5 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

2007

Inhibition of angiogenesis by the antifungal drug itraconazole

Chong, C. R., Xu, J., Lu, J., Bhat, S., Sullivan, D. J. & Liu, J. O., Apr 2007, In: ACS chemical biology. 2, 4, p. 263-270 8 p.

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Substrate-Dependent Targeting of Eukaryotic Translation Initiation Factor 4A by Pateamine A: Negation of Domain-Linker Regulation of Activity

Low, W. K., Dang, Y., Bhat, S., Romo, D. & Liu, J. O., Jun 25 2007, In: Chemistry and Biology. 14, 6, p. 715-727 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

The HBV drug entecavir - Effects on HIV-1 replication and resistance

McMahon, M. A., Jilek, B. L., Brennan, T. P., Shen, L., Zhou, Y., Wind-Rotolo, M., Xing, S., Bhat, S., Hale, B., Hegarty, R., Chong, C. R., Liu, J. O., Siliciano, R. F. & Thio, C. L., Jun 21 2007, In: New England Journal of Medicine. 356, 25, p. 2614-2621 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

223 Scopus citations

2006

UDP-Gal: GlcNAc-R β1,4-galactosyltransferase - A target enzyme for drug design. Acceptor specificity and inhibition of the enzyme

Brockhausen, I., Benn, M., Bhat, S., Marone, S., Riley, J. G., Montoya-Peleaz, P., Vlahakis, J. Z., Paulsen, H., Schutzbach, J. S. & Szarek, W. A., Nov 2006, In: Glycoconjugate Journal. 23, 7-8, p. 525-541 17 p.

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

2004

Inhibition of amyloid A amyloidogenesis in vivo and in tissue culture by 4-deoxy analogues of peracetylated 2-acetamido-2-deoxy-α- and β-D-glucose: Implications for the treatment of various amyloidoses

Kisilevsky, R., Szarek, W. A., Ancsin, J. B., Elimova, E., Marone, S., Bhat, S. & Berkin, A., Jun 2004, In: American Journal of Pathology. 164, 6, p. 2127-2137 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

2003

Novel Glycosaminoglycan Precursors as Anti-Amyloid Agents, Part III

Kisilevsky, R., Szarek, W. A., Ancsin, J., Bhat, S., Li, Z. & Marone, S., 2003, In: Journal of Molecular Neuroscience. 20, 3, p. 291-297 7 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

2002

Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells

Kisilevsky, R., Crandall, I., Szarek, W. A., Bhat, S., Tan, C., Boudreau, L. & Kain, K. C., 2002, In: Antimicrobial agents and chemotherapy. 46, 8, p. 2619-2626 8 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

2000

Targeting of phosphonoacetate to the liver: Synthesis of a phosphonoacetate-trilactoside conjugate

Bhat, S., Vaino, A. R. & Szarek, W. A., 2000, In: Israel Journal of Chemistry. 40, 3-4, p. 335-341 7 p.

Research output: Contribution to journal › Article › peer-review

1999

Isomerization of longifolene to isolongifolene catalyzed by montmorillonite clay

Ramesha, A. R., Bhat, S. & Prabhu, K. R., Apr 1999, In: Organic Preparations and Procedures International. 31, 2, p. 227-230 4 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

1996

Oxygenation of alkenes with t-BuOOH catalysed by β-cyclodextrin borate

Bhat, S. & Chandrasekaran, S., May 13 1996, In: Tetrahedron Letters. 37, 20, p. 3581-3584 4 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

1995

Reaction of Azides with Tetrathiomolybdate: Reduction and Imine Formation

Ramesha, A. R., Bhat, S. & Chandrasekaran, S., Nov 1 1995, In: Journal of Organic Chemistry. 60, 23, p. 7682-7683 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

60 Scopus citations

Sodium Perborate/Acetic Anhydride: A Convenient Reagent for the Conversion of Cyclic Acetals to Esters

Bhat, S., Ramesha, A. R. & Chandrasekaran, S., Apr 1995, In: Synlett. 1995, 4, p. 329-330 2 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

1993

A novel synthesis of 4-dioxy-2-enones from 1,3-dienes using pyridinium dichromate-tret-butyl hydroperoxide

Bhat, S., Chidambaram, N. & Chandrasekaran, S., 1993, In: Journal of the Chemical Society, Chemical Communications. 7, p. 651-652 2 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

1992

A Highly Selective Methodology for the Direct Conversion of Acetals to Esters

Chidambaram, N., Bhat, S. & Chandrasekaran, S., Aug 1 1992, In: Journal of Organic Chemistry. 57, 18, p. 5013-5015 3 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Shri Bhat

Research output

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