Research output per year
Research output per year
- 1 - 50 out of 55 results
Search results
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2025
Corrigendum to “Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis” [Europ. J. Med. Chem. 283 (2025) 117148] (European Journal of Medicinal Chemistry (2025) 283, (S0223523424010304), (10.1016/j.ejmech.2024.117148))
Zhang, X., Lun, S., Li, Y. X., Zhang, W., Zhou, R. Y., Liu, T., Yang, F., Tang, J., Bishai, W. R. & Yu, L. F., Mar 5 2025, In: European Journal of Medicinal Chemistry. 285, 117239.Research output: Contribution to journal › Comment/debate › peer-review
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Structure-based development of N-Arylindole derivatives as Pks13 inhibitors against Mycobacterium tuberculosis
Zhang, X., Lun, S., Li, Y. X., Zhang, W., Zhou, R. Y., Liu, T., Yang, F., Tang, J., Bishai, W. R. & Yu, L. F., Feb 5 2025, In: European Journal of Medicinal Chemistry. 283, 117148.Research output: Contribution to journal › Article › peer-review
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2024
Design, synthesis, and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents
Wen, Y., Lun, S., Jiao, Y., Zhang, W., Hu, T., Liu, T., Yang, F., Tang, J., Zhang, B., Bishai, W. R. & Yu, L. F., Mar 2024, In: Chinese Chemical Letters. 35, 3, 108464.Research output: Contribution to journal › Article › peer-review
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Total Syntheses of Cyclomarin and Metamarin Natural Products
Fei, F., Lun, S., Saxena, A., Raghavan, M., DeRisi, J. L., Bishai, W. R. & Sello, J. K., Nov 15 2024, In: Organic Letters. 26, 45, p. 9698-9703 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Adjunctive Integrated Stress Response Inhibition Accelerates Tuberculosis Clearance in Mice
Krug, S., Prasad, P., Xiao, S., Lun, S., Ruiz-Bedoya, C. A., Klunk, M., Ordonez, A. A., Jain, S. K., Srikrishna, G., Kramnik, I. & Bishai, W. R., Mar 2023, In: mBio. 14, 2Research output: Contribution to journal › Article › peer-review
Open Access -
Glutamine metabolism inhibition has dual immunomodulatory and antibacterial activities against Mycobacterium tuberculosis
Parveen, S., Shen, J., Lun, S., Zhao, L., Alt, J., Koleske, B., Leone, R. D., Rais, R., Powell, J. D., Murphy, J. R., Slusher, B. S. & Bishai, W. R., Dec 2023, In: Nature communications. 14, 1, 7427.Research output: Contribution to journal › Article › peer-review
Open Access -
MDA5 RNA-sensing pathway activation by Mycobacterium tuberculosis promotes innate immune subversion and pathogen survival
Korin Bullen, C., Singh, A. K., Krug, S., Lun, S., Thakur, P., Srikrishna, G. & Bishai, W. R., Oct 2023, In: JCI Insight. 8, 20, e166242.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure-directed identification of pyridine-2-methylamine derivatives as MmpL3 inhibitors for use as antitubercular agents
Wen, Y., Lun, S., Jiao, Y., Zhang, W., Liu, T., Yang, F., Tang, J., Bishai, W. R. & Yu, L. F., Jul 5 2023, In: European Journal of Medicinal Chemistry. 255, 115351.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Design, Synthesis and Biological Evaluation of N-phenylindole Derivatives as Pks13 Inhibitors against Mycobacterium tuberculosis
Cai, Y., Zhang, W., Lun, S., Zhu, T., Xu, W., Yang, F., Tang, J., Bishai, W. R. & Yu, L., May 1 2022, In: Molecules. 27, 9, 2844.Research output: Contribution to journal › Article › peer-review
Open Access -
Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment
Zhang, W., Lun, S., Wang, S. S., Cai, Y. P., Yang, F., Tang, J., Bishai, W. R. & Yu, L. F., Oct 13 2022, In: Journal of medicinal chemistry. 65, 19, p. 13240-13252 13 p.Research output: Contribution to journal › Article › peer-review
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2021
Design, synthesis and antimycobacterial evaluation of novel adamantane and adamantanol analogues effective against drug-resistant tuberculosis
Alsayed, S. S. R., Lun, S., Payne, A., Bishai, W. R. & Gunosewoyo, H., Jan 2021, In: Bioorganic Chemistry. 106, 104486.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells
Alsayed, S. S. R., Lun, S., Bailey, A. W., Suri, A., Huang, C. C., Mocerino, M., Payne, A., Sredni, S. T., Bishai, W. R. & Gunosewoyo, H., Apr 10 2021, In: RSC Advances. 11, 26, p. 15497-15511 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules
Zhang, W., Liu, L. L., Lun, S., Wang, S. S., Xiao, S., Gunosewoyo, H., Yang, F., Tang, J., Bishai, W. R. & Yu, L. F., Mar 5 2021, In: European Journal of Medicinal Chemistry. 213, 113202.Research output: Contribution to journal › Article › peer-review
Open Access -
Effective Host-Directed Therapy for Tuberculosis by Depletion of Myeloid-Derived Suppressor Cells and Related Cells Using a Diphtheria Toxin Fusion Protein
Parveen, S., Lun, S., Urbanowski, M. E., Cardin, M., Shen, J., Murphy, J. R. & Bishai, W. R., Dec 1 2021, In: Journal of Infectious Diseases. 224, 11, p. 1962-1972 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Facile synthesis and antimycobacterial activity of isoniazid, pyrazinamide and ciprofloxacin derivatives
Alsayed, S. S. R., Lun, S., Payne, A., Bishai, W. R. & Gunosewoyo, H., Jun 2021, In: Chemical Biology and Drug Design. 97, 6, p. 1137-1150 14 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
The integrated stress response mediates necrosis in murine Mycobacterium tuberculosis granulomas
Bhattacharya, B., Xiao, S., Chatterjee, S., Urbanowski, M., Ordonez, A., Ihms, E. A., Agrahari, G., Lun, S., Berland, R., Pichugin, A., Gao, Y., Connor, J., Ivanov, A. R., Yan, B. S., Kobzik, L., Koo, B. B., Jain, S., Bishai, W. & Kramnik, I., Feb 1 2021, In: Journal of Clinical Investigation. 131, 3, e130319.Research output: Contribution to journal › Article › peer-review
Open Access -
Therapeutic potential of coumestan pks13 inhibitors for tuberculosis
Lun, S., Xiao, S., Zhang, W., Wang, S., Gunosewoyo, H., Yu, L. F. & Bishai, W. R., May 2021, In: Antimicrobial agents and chemotherapy. 65, 5, e02190-20.Research output: Contribution to journal › Article › peer-review
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2020
Design, synthesis, and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents
Alsayed, S. S. R., Lun, S., Luna, G., Beh, C. C., Payne, A. D., Foster, N., Bishai, W. R. & Gunosewoyo, H., Feb 19 2020, In: RSC Advances. 10, 13, p. 7523-7540 18 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Design, synthesis, and biological evaluation of novel imidazo[1,2-a]pyridinecarboxamides as potent anti-tuberculosis agents
Onajole, O. K., Lun, S., Yun, Y. J., Langue, D. Y., Jaskula-Dybka, M., Flores, A., Frazier, E., Scurry, A. C., Zavala, A., Arreola, K. R., Pierzchalski, B., Ayitou, A. J. L. & Bishai, W. R., Dec 2020, In: Chemical Biology and Drug Design. 96, 6, p. 1362-1371 10 p.Research output: Contribution to journal › Letter › peer-review
1 Scopus citations -
The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes
Cao, R., Islamoglu, H., Teskey, G., Gyurjian, K., Abrahem, R., Onajole, O. K., Lun, S., Bishai, W., Kozikowski, A. P., Fraix, M. P., Sathananthan, A., Zhong, L., Stec, J. & Venketaraman, V., May 1 2020, In: International Microbiology. 23, 2, p. 161-170 10 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
2019
Advancing the therapeutic potential of indoleamides for tuberculosis
Lun, S., Tasneen, R., Chaira, T., Stec, J., Onajole, O. K., Yang, T. J., Cooper, C. B., Mdluli, K., Converse, P., Nuermberger, E. L., Samuel Raj, V., Kozikowski, A. & Bishai, W. R., 2019, In: Antimicrobial agents and chemotherapy. 63, 7, e00343-19.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Correction: Mycobacterial Gene cuvA Is Required for Optimal Nutrient Utilization and Virulence (Infection and Immunity (2014) 82:10 (4104-4117) DOI: 10.1128/IAI.02207-14)
Mir, M., Prisic, S., Kang, C. M., Lun, S., Guo, H., Murry, J. P., Rubin, E. J. & Husson, R. N., 2019, In: Infection and immunity. 87, 8, e00414.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II
Zhang, W., Lun, S., Liu, L. L., Xiao, S., Duan, G., Gunosewoyo, H., Yang, F., Tang, J., Bishai, W. R. & Yu, L. F., Apr 11 2019, In: Journal of medicinal chemistry. 62, 7, p. 3575-3589 15 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Revisiting the β-lactams for tuberculosis therapy with a compound-compound synthetic lethality approach
Xiao, S., Guo, H., Weiner, W. S., Maddox, C., Mao, C., Gunosewoyo, H., Pelly, S., Lucile White, E., Rasmussen, L., Schoenen, F. J., Aubé, J., Bishai, W. R. & Lun, S., 2019, In: Antimicrobial agents and chemotherapy. 63, 11, e0131919.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2018
Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis
Zhang, W., Lun, S., Wang, S. H., Jiang, X. W., Yang, F., Tang, J., Manson, A. L., Earl, A. M., Gunosewoyo, H., Bishai, W. R. & Yu, L. F., Feb 8 2018, In: Journal of medicinal chemistry. 61, 3, p. 791-803 13 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations -
2017
Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections
Kozikowski, A. P., Onajole, O. K., Stec, J., Dupont, C., Viljoen, A., Richard, M., Chaira, T., Lun, S., Bishai, W., Raj, V. S., Ordway, D. & Kremer, L., Jul 13 2017, In: Journal of medicinal chemistry. 60, 13, p. 5876-5888 13 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2016
Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection
Stec, J., Onajole, O. K., Lun, S., Guo, H., Merenbloom, B., Vistoli, G., Bishai, W. R. & Kozikowski, A. P., Jul 14 2016, In: Journal of medicinal chemistry. 59, 13, p. 6232-6247 16 p.Research output: Contribution to journal › Article › peer-review
73 Scopus citations -
2015
Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis
Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R., Aug 1 2015, In: EBioMedicine. 2, 8, p. 868-873 6 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873] DOI: 10.1016/j.ebiom.2015.07.014
Maiga, M., Ahidjo, B. A., Maiga, M. C., Cheung, L., Pelly, S., Lun, S., Bougoudogo, F. & Bishai, W. R., Nov 1 2015, In: EBioMedicine. 2, 11, p. 1834 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Mutation of Rv2887, a marR-Like gene, confers mycobacterium tuberculosis resistance to an imidazopyridine-based agent
Winglee, K., Lun, S., Pieroni, M., Kozikowski, A. & Bishai, W., Nov 1 2015, In: Antimicrobial agents and chemotherapy. 59, 11, p. 6873-6881 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2014
Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of mycobacterium tuberculosis
Stec, J., Vilchèze, C., Lun, S., Perryman, A. L., Wang, X., Freundlich, J. S., Bishai, W., Jacobs, W. R. & Kozikowski, A. P., Nov 1 2014, In: ChemMedChem. 9, 11, p. 2528-2537 10 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence
Mir, M., Prisic, S., Kang, C. M., Lun, S., Guo, H., Murry, J. P., Rubin, E. J. & Husson, R. N., 2014, In: Infection and immunity. 82, 10, p. 4104-4117 14 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Synthetic lethality reveals mechanisms of Mycobacterium tuberculosis resistance to β-lactams
Lun, S., Miranda, D., Kubler, A., Guo, H., Maiga, M. C., Winglee, K., Pelly, S. & Bishai, W. R., Sep 16 2014, In: mBio. 5, 5, e01767-14.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2013
Detection of inhibitors of phenotypically drug-tolerant Mycobacterium tuberculosis using an in vitro bactericidal screen
Bassett, I. M., Lun, S., Bishai, W. R., Guo, H., Kirman, J. R., Altaf, M. & O'Toole, R. F., Oct 2013, In: Journal of Microbiology. 51, 5, p. 651-658 8 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Indoleamides are active against drug-resistant mycobacterium tuberculosis
Lun, S., Guo, H., Onajole, O. K., Pieroni, M., Gunosewoyo, H., Chen, G., Tipparaju, S. K., Ammerman, N. C., Kozikowski, A. P. & Bishai, W. R., Dec 19 2013, In: Nature communications. 4, 2907.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice
Lun, S., Guo, H., Adamson, J., Cisar, J. S., Davis, T. D., Chavadi, S. S., Warren, J. D., Quadri, L. E. N., Tan, D. S. & Bishai, W. R., Oct 2013, In: Antimicrobial agents and chemotherapy. 57, 10, p. 5138-5140 3 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Preliminary structure - Activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains
Onajole, O. K., Pieroni, M., Tipparaju, S. K., Lun, S., Stec, J., Chen, G., Gunosewoyo, H., Guo, H., Ammerman, N. C., Bishai, W. R. & Kozikowski, A. P., May 23 2013, In: Journal of medicinal chemistry. 56, 10, p. 4093-4103 11 p.Research output: Contribution to journal › Article › peer-review
84 Scopus citations -
2012
Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis
Chopra, S., Matsuyama, K., Tran, T., Malerich, J. P., Wan, B., Franzblau, S. G., Lun, S., Guo, H., Maiga, M. C., Bishai, W. R. & Madrid, P. B., Feb 2012, In: Journal of Antimicrobial Chemotherapy. 67, 2, p. 415-421 7 p., dkr449.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis
Lee, J. H., Ammerman, N., Nolan, S., Geiman, D. E., Lun, S., Guo, H. & Bishai, W. R., 2012, In: Nature communications. 3, 753.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Risk of tuberculosis reactivation with tofacitinib (CP-690550)
Maiga, M., Lun, S., Guo, H., Winglee, K., Ammerman, N. C. & Bishai, W. R., Jun 1 2012, In: Journal of Infectious Diseases. 205, 11, p. 1705-1708 4 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Rv2190c, an NlpC/P60 Family Protein, Is Required for Full Virulence of Mycobacterium tuberculosis
Parthasarathy, G., Lun, S., Guo, H., Ammerman, N. C., Geiman, D. E. & Bishai, W. R., Aug 31 2012, In: PloS one. 7, 8, e43429.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model
Maiga, M., Agarwal, N., Ammerman, N. C., Gupta, R., Guo, H., Maiga, M. C., Lun, S. & Bishai, W. R., Feb 3 2012, In: PloS one. 7, 2, e30749.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
2011
Alterations in phospholipid catabolism in Mycobacterium tuberculosis lysX mutant
Maloney, E., Lun, S., Stankowska, D., Guo, H., Rajagoapalan, M., Bishai, W. R. & Madiraju, M. V., 2011, In: Frontiers in Microbiology. 2, FEBResearch output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Pyrido[1,2-a]benzimidazole-Based Agents Active Against Tuberculosis (TB), Multidrug-Resistant (MDR) TB and Extensively Drug-Resistant (XDR) TB
Pieroni, M., Tipparaju, S. K., Lun, S., Song, Y., Sturm, A. W., Bishai, W. R. & Kozikowski, A. P., Feb 7 2011, In: ChemMedChem. 6, 2, p. 334-342 9 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
2010
Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery
Nisa, S., Blokpoel, M. C. J., Robertson, B. D., Tyndall, J. D. A., Lun, S., Bishai, W. R. & O'Toole, R., Sep 1 2010, In: Journal of Antimicrobial Chemotherapy. 65, 11, p. 2347-2358 12 p., dkq311.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
The Impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models
Converse, P., Eisenach, K. D., Theus, S. A., Nuermberger, E. L., Tyagi, S., Ly, L. H., Geiman, D. E., Guo, H., Nolan, S. T., Akar, N. C., Klinkenberg, L., Gupta, R., Lun, S., Karakousis, P. C., Lamichhane, G., McMurray, D. N., Grosset, J. H. & Bishai, W. R., 2010, In: PloS one. 5, 4, e10292.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2009
Extrapulmonary dissemination of mycobacterium bovis but not mycobacterium tuberculosis in a bronchoscopic rabbit model of cavitary tuberculosis
Nedeltchev, G. G., Raghunand, T. R., Jassal, M. S., Lun, S., Cheng, Q. J. & Bishai, W. R., Feb 2009, In: Infection and immunity. 77, 2, p. 598-603 6 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides
Maloney, E., Stankowska, D., Zhang, J., Fol, M., Cheng, Q. J., Lun, S., Bishai, W. R., Rajagopalan, M., Chatterjee, D. & Madiraju, M. V., Jul 2009, In: PLoS pathogens. 5, 7, e1000534.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2008
Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin
Östensson, K. & Lun, S., 2008, In: Acta Veterinaria Scandinavica. 50, 1, 26.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2007
Characterization of a novel cell wall-anchored protein with carboxylesterase activity required for virulence in Mycobacterium tuberculosis
Lun, S. & Bishai, W. R., Jun 22 2007, In: Journal of Biological Chemistry. 282, 25, p. 18348-18356 9 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations