Research output per year
Research output per year
- 1 - 50 out of 197 results
Search results
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2024
Magnetic Resonance Imaging–Based Assessment of Pancreatic Fat Strongly Correlates With Histology-Based Assessment of Pancreas Composition
Kiemen, A. L., Dbouk, M., Diwan, E. A., Forjaz, A., Dequiedt, L., Baghdadi, A., Madani, S. P., Grahn, M. P., Jones, C., Vedula, S., Wu, P. H., Wirtz, D., Kern, S., Goggins, M., Hruban, R., Kamel, I. R. & Canto, M. I., Feb 1 2024, In: Pancreas. 53, 2, p. E180-E186Research output: Contribution to journal › Article › peer-review
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2015
Are we systematically under-dosing patients with fluorouracil?
Gormley, P. E., Kern, S. E. & Cunningham, S. C., Mar 1 2015, In: Journal of Clinical Oncology. 33, 7, p. e36-e37Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Genome annotation by shotgun inactivation of a native gene in hemizygous cells: Application to BRCA2 with implication of hypomorphic variants
Ghosh, S., Bhunia, A. K., Paun, B. C., Gilbert, S. F., Dhru, U., Patel, K. & Kern, S. E., Feb 1 2015, In: Human mutation. 36, 2, p. 260-269 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2014
Hypersensitivities for acetaldehyde and other agents among cancer cells null for clinically relevant fanconi anemia genes
Ghosh, S., Sur, S., Yerram, S. R., Rago, C., Bhunia, A. K., Hossain, M. Z., Paun, B. C., Ren, Y. R., Iacobuzio-Donahue, C. A., Azad, N. A. & Kern, S. E., Jan 2014, In: American Journal of Pathology. 184, 1, p. 260-270 11 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
PLM: Is out of the Box a Reality?
Kern, S., Aug 2014, Apparel, 56, 8.Research output: Contribution to specialist publication › Article
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Salivary α-amylase, serum albumin, and myoglobin protect against DNA-damaging activities of ingested dietary agents in vitro
Hossain, M. Z., Patel, K. & Kern, S. E., Aug 2014, In: Food and Chemical Toxicology. 70, p. 114-119 6 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2013
Biological clues to potent DNA-damaging activities in food and flavoring
Hossain, M. Z., Gilbert, S. F., Patel, K., Ghosh, S., Bhunia, A. & Kern, S. E., May 2013, In: Food and Chemical Toxicology. 55, p. 557-567 11 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
DNA-intercalators causing rapid re-expression of methylated and silenced genes in cancer cells
Hossain, M. Z., Healey, M. A., Lee, C., Poh, W., Yerram, S. R., Patel, K., Azad, N. S., Herman, J. G. & Kern, S. E., 2013, In: Oncotarget. 4, 2, p. 298-309 12 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
FAM190A deficiency creates a cell division defect
Patel, K., Scrimieri, F., Ghosh, S., Zhong, J., Kim, M. S., Ren, Y. R., Morgan, R. A., Iacobuzio-Donahue, C. A., Pandey, A. & Kern, S. E., Jul 2013, In: American Journal of Pathology. 183, 1, p. 296-303 8 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
"Selective cell death mediated by small conditional RNAs" is not selective
Patel, K. & Kern, S. E., Aug 2013, In: Cancer Biology and Therapy. 14, 8, p. 693-696 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
Analysis of polymorphisms and haplotype structure of the human thymidylate synthase genetic region: A tool for pharmacogenetic studies
Ghosh, S., Hossain, M. Z., Borges, M., Goggins, M. G., Ingersoll, R. G., Eshleman, J. R., Klein, A. P. & Kern, S. E., Apr 5 2012, In: PloS one. 7, 4, e34426.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing
Patel, K., Yerram, S. R., Azad, N. A. & Kern, S. E., Jul 2012, In: Oncotarget. 3, 7, p. 678-685 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin
Ren, Y. R., Chaerkady, R., Hu, S., Wan, J., Qian, J., Zhu, H., Pandey, A. & Kern, S. E., Nov 2 2012, In: Journal of proteome research. 11, 11, p. 5301-5310 10 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2011
FAM190A rearrangements provide a multitude of individualized tumor signatures and neo-antigens in cancer
Scrimieri, F., Calhoun, E. S., Patel, K., Gupta, R., Huso, D. L., Hruban, R. H. & Kern, S. E., 2011, In: Oncotarget. 2, 1-2, p. 69-75 7 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
Denicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., Scrimieri, F., Winter, J. M., Hruban, R. H., Iacobuzio-Donahue, C., Kern, S. E., Blair, I. A. & Tuveson, D. A., Jul 7 2011, In: Nature. 475, 7354, p. 106-110 5 p.Research output: Contribution to journal › Article › peer-review
Open Access1237 Scopus citations -
Reexamining a proposal: Thymidylate synthase 5′-untranslated region as a regulator of translation efficiency
Ghosh, S., Winter, J. M., Patel, K. & Kern, S. E., Oct 15 2011, In: Cancer Biology and Therapy. 12, 8, p. 750-755 6 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers
Ren, Y. R., Patel, K., Paun, B. C. & Kern, S. E., Apr 8 2011, In: Journal of Biological Chemistry. 286, 14, p. 11960-11969 10 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2010
Improved DNA electrophoresis in conditions favoring polyborates and lewis acid complexation
Singhal, H., Ren, Y. R. & Kern, S. E., 2010, In: PloS one. 5, 6, e11318.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Where's the passion?
Kern, S. E., Oct 1 2010, In: Cancer Biology and Therapy. 10, 7, p. 655-657 3 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2009
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene
Jones, S., Hruban, R. H., Kamiyama, M., Borges, M., Zhang, X., Parsons, D. W., Lin, J. C. H., Palmisano, E., Brune, K., Jaffee, E. M., Iacobuzio-Donahue, C. A., Maitra, A., Parmigiani, G., Kern, S. E., Velculescu, V. E., Kinzler, K. W., Vogelstein, B., Eshleman, J. R., Goggins, M. & Klein, A. P., Apr 10 2009, In: Science. 324, 5924, p. 217 1 p.Research output: Contribution to journal › Article › peer-review
Open Access577 Scopus citations -
Hybrids of aneuploid human cancer cells permit complementation of simple and complex cancer defects
Dezentje, D. A., Arking, D. E., Kortenhorst, M. S. Q., West, K., Chakravarti, A. & Kern, S. E., Feb 15 2009, In: Cancer Biology and Therapy. 8, 4, p. 347-355 9 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence
Brody, J. R., Hucl, T., Costantino, C. L., Eshleman, J. R., Gallmeier, E., Zhu, H., Van Der Heijden, M. S., Winter, J. M., Wikiewicz, A. K., Yeo, C. J. & Kern, S. E., Feb 1 2009, In: Cancer Research. 69, 3, p. 984-991 8 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2008
Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer
Winter, J. M., Ting, A. H., Vilardell, F., Gallmeier, E., Baylin, S. B., Hruban, R. H., Kern, S. E. & Iacobuzio-Donahue, C. A., Jan 15 2008, In: Clinical Cancer Research. 14, 2, p. 412-418 7 p.Research output: Contribution to journal › Article › peer-review
Open Access113 Scopus citations -
A syngeneic variance library for functional annotation of human variation: Application to BRCA2
Hucl, T., Rago, C., Gallmeier, E., Brody, J. R., Gorospe, M. & Kern, S. E., Jul 1 2008, In: Cancer Research. 68, 13, p. 5023-5030 8 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C. H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S. M., Fu, B., Lin, M. T., Calhoun, E. S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D. R., & 16 others, Sep 26 2008, In: Science. 321, 5897, p. 1801-1806 6 p.Research output: Contribution to journal › Article › peer-review
Open Access2827 Scopus citations -
Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil: Is it time to move forward?
Showalter, S. L., Showalter, T. N., Witkiewicz, A., Havens, R., Kennedy, E. P., Hucl, T., Kern, S. E., Yeo, C. J. & Brody, J. R., Jul 2008, In: Cancer Biology and Therapy. 7, 7, p. 986-994 9 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
SOS1 mutations are rare in human malignancies: Implications for Noonan syndrome patients
Swanson, K. D., Winter, J. M., Reis, M., Bentires-Alj, M., Greulich, H., Grewal, R., Hruban, R. H., Yeo, C. J., Yassin, Y., Iartchouk, O., Montgomery, K., Whitman, S. P., Caligiuri, M. A., Loh, M. L., Gilliland, D. G., Look, A. T., Kucherlapati, R., Kern, S. E., Meyerson, M. & Neel, B. G., Mar 2008, In: Genes Chromosomes and Cancer. 47, 3, p. 253-259 7 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2007
Ancestral trees for modeling stem cell lineages genetically rather Than functionally: Understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis
Shibata, D. K. & Kern, S. E., 2007, In: Breast Disease. 29, p. 15-25 11 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Clinical importance of precursor lesions in the pancreas
Hruban, R. H., Takaori, K., Canto, M., Fishman, E. K., Campbell, K., Brune, K., Kern, S. E. & Goggins, M., May 2007, In: Journal of Hepato-Biliary-Pancreatic Surgery. 14, 3, p. 255-263 9 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
Gene-specific selection against experimental fanconi anemia gene inactivation in human cancer
Gallmeier, E., Hucl, T., Calhoun, E. S., Cunningham, S. C., Bunz, F., Brody, J. R. & Kern, S. E., May 2007, In: Cancer Biology and Therapy. 6, 5, p. 654-660 7 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor-dependent MCAT motif
Hucl, T., Brody, J. R., Gallmeier, E., Iacobuzio-Donahue, C. A., Farrance, I. K. & Kern, S. E., Oct 1 2007, In: Cancer Research. 67, 19, p. 9055-9065 11 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
High-throughput screening identifies novel agents eliciting hypersensitivity in Fanconi pathway-deficient cancer cells
Gallmeier, E., Hucl, T., Brody, J. R., Dezentje, D. A., Tahir, K., Kasparkova, J., Brabec, V., Bachman, K. E. & Kern, S. E., Mar 1 2007, In: Cancer Research. 67, 5, p. 2169-2177 9 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Radiolabeled anti-claudin 4 and anti-prostate stem cell antigen: Initial imaging in experimental models of pancreatic cancer
Foss, C. A., Fox, J. J., Feldmann, G., Maitra, A., Iacobuzio-Donohue, C., Kern, S. E., Hruban, R. & Pomper, M. G., Mar 2007, In: Molecular imaging. 6, 2, p. 131-139 9 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
The fuzzy math of solid tumor stem cells: A perspective
Kern, S. E. & Shibata, D., Oct 1 2007, In: Cancer Research. 67, 19, p. 8985-8988 4 p.Research output: Contribution to journal › Article › peer-review
86 Scopus citations -
2006
A proposed clinical test for monitoring fluoropyrimidine therapy: Detection and stability of thymidylate synthase ternary complexes
Brody, J. R., Gallmeier, E., Yoshimura, K., Hucl, T., Kulesza, P., Canto, M. I., Hruban, R. H., Schulick, R. D. & Kern, S. E., Aug 2006, In: Cancer Biology and Therapy. 5, 8, p. 923-927 5 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Beverage-agarose gel electrophoresis: An inquiry-based laboratory exercise with virtual adaptation
Cunningham, S. C., McNear, B., Pearlman, R. S. & Kern, S. E., 2006, In: CBE life sciences education. 5, 3, p. 281-286 6 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Does tumorigenesis select for or against mutations of the DNA repair-associated genes BRCA2 and MRE1 1: Considerations from somatic mutations in microsatellite unstable (MSI) gastrointestinal cancers
van der Heijden, M. S., Brody, J. R., Elghalbzouri-Maghrani, E., Zdzienicka, M. & Kern, S. E., Jan 17 2006, In: BMC genetics. 7Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: A model for patient classification to aid fluoropyrimidine therapy
Brody, J. R., Hucl, T., Gallmeier, E., Winter, J. M., Kern, S. E. & Murphy, K. M., Oct 1 2006, In: Cancer Research. 66, 19, p. 9369-9373 5 p.Research output: Contribution to journal › Article › peer-review
31 Scopus citations -
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays
Calhoun, E. S., Hucl, T., Gallmeier, E., West, K. M., Arking, D. E., Maitra, A., Iacobuzio-Donahue, C., Chakravarti, A., Hruban, R. H. & Kern, S. E., Aug 15 2006, In: Cancer Research. 66, 16, p. 7920-7928 9 p.Research output: Contribution to journal › Article › peer-review
78 Scopus citations -
MKK4 status predicts survival after resection of gastric adenocarcinoma
Cunningham, S. C., Kamangar, F., Kim, M. P., Hammoud, S., Haque, R., Iacobuzio-Donahue, C., Ashfaq, R., Kern, S. E., Maitra, A., Heitmiller, R. E., Choti, M. A., Lillemoe, K. D., Cameron, J. L., Yeo, C. J., Montgomery, E. & Schulick, R. D., 2006, In: Archives of surgery. 141, 11, p. 1095-1099 5 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
Molecular pathogenesis of pancreatic cancer
Maitra, A., Kern, S. E. & Hruban, R. H., Apr 2006, In: Best Practice and Research: Clinical Gastroenterology. 20, 2, p. 211-226 16 p.Research output: Contribution to journal › Article › peer-review
143 Scopus citations -
Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer
Brune, K., Abe, T., Canto, M., O'Malley, L., Klein, A. P., Maitra, A., Volkan Adsay, N., Fishman, E. K., Cameron, J. L., Yeo, C. J., Kern, S. E., Goggins, M. & Hruban, R. H., Sep 2006, In: American Journal of Surgical Pathology. 30, 9, p. 1067-1076 10 p.Research output: Contribution to journal › Article › peer-review
235 Scopus citations -
Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers.
Wood, L. D., Calhoun, E. S., Silliman, N., Ptak, J., Szabo, S., Powell, S. M., Riggins, G. J., Wang, T. L., Yan, H., Gazdar, A., Kern, S. E., Pennacchio, L., Kinzler, K. W., Vogelstein, B. & Velculescu, V. E., Oct 2006, In: Human mutation. 27, 10, p. 1060-1061 2 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Targeted deletion of MKK4 in cancer cells: A detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss
Cunningham, S. C., Gallmeier, E., Hucl, T., Dezentje, D. A., Calhoun, E. S., Falco, G., Abdelmohsen, K., Gorospe, M. & Kern, S. E., Jun 1 2006, In: Cancer Research. 66, 11, p. 5560-5564 5 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Targeted Disruption of FANCC and FANCG in Human Cancer Provides a Preclinical Model for Specific Therapeutic Options
Gallmeier, E., Calhoun, E. S., Rago, C., Brody, J. R., Cunningham, S. C., Hucl, T., Gorospe, M., Kohli, M., Lengauer, C. & Kern, S. E., Jul 2006, In: Gastroenterology. 130, 7, p. 2145-2154 10 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
Theoretical proposal: Allele dosage of MAP2K4/MKK4 could rationalize frequent 17p loss in diverse human cancers
Cunningham, S. C., Gallmeier, E., Hucl, T., Dezentje, D. A., Abdelmohsen, K., Gorospe, M. & Kern, S. E., May 15 2006, In: Cell Cycle. 5, 10, p. 1090-1093 4 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2005
Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: Evidence of homozygous deletion in a noninvasive precursor lesion
Hustinx, S. R., Leoni, L. M., Yeo, C. J., Brown, P. N., Goggins, M., Kern, S. E., Hruban, R. H. & Maitra, A., Jul 2005, In: Modern Pathology. 18, 7, p. 959-963 5 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: A potential new target for therapy
Hustinx, S. R., Hruban, R. H., Leoni, L. M., Iacobuzio-Donahue, C., Cameron, J. L., Yeo, C. J., Brown, P. N., Argani, P., Ashfaq, R., Fukushima, N., Goggins, M., Kern, S. E. & Maitra, A., Jan 2005, In: Cancer Biology and Therapy. 4, 1, p. 83-86 4 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
Increased prevalence of the BRCA2 polymorphic stop codon K3326X among individuals with familial pancreatic cancer
Martin, S. T., Matsubayashi, H., Rogers, C. D., Philips, J., Couch, F. J., Brune, K., Yeo, C. J., Kern, S. E., Hruban, R. H. & Goggins, M., May 19 2005, In: Oncogene. 24, 22, p. 3652-3656 5 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
In vivo therapeutic responses contingent on fanconi anemia/BRCA2 status of the tumor
Van Der Heijden, M. S., Brody, J. R., Dezentje, D. A., Gallmeier, E., Cunningham, S. C., Swartz, M. J., DeMarzo, A. M., Offerhaus, G. J. A., Isacoff, W. H., Hruban, R. H. & Kern, S. E., Oct 15 2005, In: Clinical Cancer Research. 11, 20, p. 7508-7515 8 p.Research output: Contribution to journal › Article › peer-review
132 Scopus citations