Research output per year
Research output per year
- 1 - 50 out of 64 results
Search results
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2023
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
Sengupta, S., Zhang, J., Reed, M. C., Yu, J., Kim, A., Boronina, T. N., Board, N. L., Wrabl, J. O., Shenderov, K., Welsh, R. A., Yang, W., Timmons, A. E., Hoh, R., Cole, R. N., Deeks, S. G., Siliciano, J. D., Siliciano, R. F. & Sadegh-Nasseri, S., Jul 3 2023, In: Journal of Experimental Medicine. 220, 7, e20221654.Research output: Contribution to journal › Article › peer-review
Open Access -
Commensal bacteria maintain a Qa-1b-restricted unconventional CD8+ T population in gut epithelium
Guan, J., Peske, J. D., Valerio, M. M., Park, C., Robey, E. A. & Sadegh-Nasseri, S., Dec 2023, In: eLife. 12, RP90466.Research output: Contribution to journal › Article › peer-review
Open Access -
H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity
Welsh, R. A., Song, N., Park, C. S., Peske, J. D. & Sadegh-Nasseri, S., 2023, In: Frontiers in immunology. 14, 1304798.Research output: Contribution to journal › Article › peer-review
Open Access -
Proper development of long-lived memory CD4 T cells requires HLA-DO function
Song, N., Welsh, R. A. & Sadegh-Nasseri, S., 2023, In: Frontiers in immunology. 14, 1277609.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
TCR-mimic bispecific antibodies to target the HIV-1 reservoir
Sengupta, S., Board, N. L., Wu, F., Moskovljevic, M., Douglass, J., Zhang, J., Reinhold, B. R., Duke-Cohan, J., Yu, J., Reed, M. C., Tabdili, Y., Azurmendi, A., Fray, E. J., Zhang, H., Hsiue, E. H. C., Jenike, K., Ho, Y. C., Gabelli, S. B., Kinzler, K. W. & Vogelstein, B. & 5 others, , Apr 12 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 15, e2123406119.Research output: Contribution to journal › Article › peer-review
Open Access -
The ER Aminopeptidases, ERAP1 and ERAP2, synergize to self-modulate their respective activities
Martín-Esteban, A., Rodriguez, J. C., Peske, D., Lopez de Castro, J. A., Shastri, N. & Sadegh-Nasseri, S., Dec 8 2022, In: Frontiers in immunology. 13, 1066483.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Editorial overview: Nature repeating itself: conformational flexibility determines MHC class I and class II epitope selection
Sadegh-Nasseri, S. & Springer, S., Jun 2021, In: Current Opinion in Immunology. 70, p. iii-ivResearch output: Contribution to journal › Editorial › peer-review
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How Does B Cell Antigen Presentation Affect Memory CD4 T Cell Differentiation and Longevity?
Welsh, R. A., Song, N. & Sadegh-Nasseri, S., Jun 10 2021, In: Frontiers in immunology. 12, 677036.Research output: Contribution to journal › Review article › peer-review
Open Access -
Partnering for the major histocompatibility complex class II and antigenic determinant requires flexibility and chaperons
Sadegh-Nasseri, S., Jun 2021, In: Current Opinion in Immunology. 70, p. 112-121 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
2020
How a proposed hypothesis during my phd training shaped my career
Sadegh-Nasseri, S., 2020, In: Critical reviews in immunology. 40, 5, p. 449-464 16 p.Research output: Contribution to journal › Article › peer-review
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Lack of the MHC class II chaperone H2-O causes susceptibility to autoimmune diseases
Welsh, R. A., Song, N., Foss, C. A., Boronina, T., Cole, R. N. & Sadegh-Nasseri, S., Feb 2020, In: PLoS biology. 18, 2, e3000590.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence
Song, N., Sengupta, S., Khoruzhenko, S., Welsh, R. A., Kim, A. R., Kumar, M. R., Sønder, S. U., Sidhom, J. W., Zhang, H., Jie, C., Siliciano, R. F. & Sadegh-Nasseri, S., Nov 2020, In: Cellular Immunology. 357, 104210.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
The love and hate relationship of HLA-DM/DO in the selection of immunodominant epitopes
Welsh, R. A. & Sadegh-Nasseri, S., Jun 2020, In: Current Opinion in Immunology. 64, p. 117-123 7 p.Research output: Contribution to journal › Review article › peer-review
3 Scopus citations -
2019
A Public BCR Present in a Unique Dual-Receptor-Expressing Lymphocyte from Type 1 Diabetes Patients Encodes a Potent T Cell Autoantigen
Ahmed, R., Omidian, Z., Giwa, A., Cornwell, B., Majety, N., Bell, D. R., Lee, S., Zhang, H., Michels, A., Desiderio, S., Sadegh-Nasseri, S., Rabb, H., Gritsch, S., Suva, M. L., Cahan, P., Zhou, R., Jie, C., Donner, T. & Hamad, A. R. A., May 30 2019, In: Cell. 177, 6, p. 1583-1599.e16Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Selection of immunodominant epitopes during antigen processing is hierarchical
Sadegh-Nasseri, S. & Kim, A. R., Sep 2019, In: Molecular Immunology. 113, p. 115-119 5 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Studying MHC class II peptide loading and editing in vitro
Kim, A. R., Ishizuka, I. E., Hartman, I. Z., Poluektov, Y., Narayan, K. & Sadegh-Nasseri, S., 2019, Methods in Molecular Biology. Humana Press Inc., p. 343-355 13 p. (Methods in Molecular Biology; vol. 1988).Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
What to do with HLA-DO/H-2O two decades later?
Welsh, R., Song, N. & Sadegh-Nasseri, S., Mar 1 2019, In: Immunogenetics. 71, 3, p. 189-196 8 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
2017
Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen during Antigen-Processing
Kim, A. R., Boronina, T. N., Cole, R. N., Darrah, E. & Sadegh-Nasseri, S., Apr 19 2017, In: Scientific reports. 7, 46418.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis
Darrah, E., Kim, A., Zhang, X., Boronina, T., Cole, R. N., Fava, A., Giles, J. T., Bingham, C. O., Chalmers, M. J., Griffin, P. R., Sadegh-Nasseri, S. & Rosen, A., Jan 6 2017, In: Journal of proteome research. 16, 1, p. 355-365 11 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2016
A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells.
Sadegh-Nasseri, S., 2016, In: F1000Research. 5, 1305.Research output: Contribution to journal › Review article › peer-review
Open Access12 Scopus citations -
2015
Determinants of immunodominance for CD4 T cells
Kim, A. R. & Sadegh-Nasseri, S., Jun 1 2015, In: Current Opinion in Immunology. 34, p. 9-15 7 p.Research output: Contribution to journal › Review article › peer-review
34 Scopus citations -
Exogenous antigens bind MHC class II first, and are processed by cathepsins later
Sadegh-Nasseri, S. & Kim, A. R., Jul 8 2015, In: Molecular Immunology. 68, 2, p. 81-84 4 p.Research output: Contribution to journal › Review article › peer-review
21 Scopus citations -
MHC class II auto-antigen presentation is unconventional
Sadegh-Nasseri, S. & Kim, A. R., 2015, In: Frontiers in immunology. 6, JUL, 372.Research output: Contribution to journal › Short survey › peer-review
Open Access21 Scopus citations -
2014
Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources
Kim, A., Hartman, I. Z., Poore, B., Boronina, T., Cole, R. N., Song, N., Ciudad, M. T., Caspi, R. R., Jaraquemada, D. & Sadegh-Nasseri, S., 2014, In: Nature communications. 5, 5369.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
2013
HLA-DO and its role in MHC class II antigen presentation
Poluektov, Y. O., Kim, A. R. & Sadegh-Nasseri, S., 2013, In: Frontiers in immunology. 4, AUG, Article 260.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
HLA-DO as the Optimizer of Epitope Selection for MHC Class II Antigen Presentation
Poluektov, Y. O., Kim, A. R., Hartman, I. Z. & Sadegh-Nasseri, S., Aug 8 2013, In: PloS one. 8, 8, e71228.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Mix to validate: A facile, reversible pegylation for fast screening of potential therapeutic proteins in vivo
Kim, T. H., Swierczewska, M., Oh, Y., Kim, A., Jo, D. G., Park, J. H., Byun, Y., Sadegh-Nasseri, S., Pomper, M. G., Lee, K. C. & Lee, S., Jul 1 2013, In: Angewandte Chemie - International Edition. 52, 27, p. 6880-6884 5 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Studying MHC class II peptide loading and editing in vitro
Kim, A., Ishizuka, I., Hartman, I., Poluektov, Y., Narayan, K. & Sadegh-Nasseri, S., 2013, Antigen Processing: Methods and Protocols. Humana Press Inc., p. 447-459 13 p. (Methods in Molecular Biology; vol. 960).Research output: Chapter in Book/Report/Conference proceeding › Chapter
8 Scopus citations -
2012
How HLA-DM molecules work: Recognition of MHC II conformational heterogeneity
Sadegh-Nasseri, S., Chou, C. L., Hartman, I. Z., Kim, A. & Narayan, K., Jun 1 2012, In: Frontiers in Bioscience - Scholar. 4 S, 4, p. 1325-1332 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2011
Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells
Dalai, S. K., Khoruzhenko, S., Drake, C. G., Jie, C. C. & Sadegh-Nasseri, S., Nov 2011, In: Immunology and Cell Biology. 89, 8, p. 870-881 12 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2010
A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes
Hartman, I. Z., Kim, A., Cotter, R. J., Walter, K., Dalai, S. K., Boronina, T., Griffith, W., Lanar, D. E., Schwenk, R., Krzych, U., Cole, R. N. & Sadegh-Nasseri, S., Nov 2010, In: Nature medicine. 16, 11, p. 1333-1340 8 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection
Sadegh-Nasseri, S., Natarajan, S., Chou, C. L., Hartman, I. Z., Narayan, K. & Kim, A., Jul 2010, In: Immunologic Research. 47, 1-3, p. 56-64 9 p.Research output: Contribution to journal › Review article › peer-review
Open Access21 Scopus citations -
Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy
Sadegh-Nasseri, S., Dalai, S. K., Korb Ferris, L. C. & Mirshahidi, S., Jan 2010, In: Immunology. 129, 1, p. 1-7 7 p.Research output: Contribution to journal › Review article › peer-review
24 Scopus citations -
2009
HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1
Narayan, K., Su, K. W., Chou, C. L., Khoruzhenko, S. & Sadegh-Nasseri, S., Sep 2009, In: Molecular Immunology. 46, 15, p. 3157-3162 6 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Staphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cells
Narayan, K., Perkins, E. M., Murphy, G. E., Dalai, S. K., Edidin, M., Subramaniam, S. & Sadegh-Nasseri, S., Jul 9 2009, In: PloS one. 4, 7, e6188.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2008
Anergy in memory CD4+ T cells is induced by B cells
Dalai, S. K., Mirshahidi, S., Morrot, A., Zavala, F. & Sadegh-Nasseri, S., Sep 1 2008, In: Journal of Immunology. 181, 5, p. 3221-3231 11 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Short peptide sequences mimic HLA-DM functions
Chou, C. L., Mirshahidi, S., Su, K. W., Kim, A. R., Narayan, K., Khoruzhenko, S., Xu, M. & Sadegh-Nasseri, S., Apr 2008, In: Molecular Immunology. 45, 7, p. 1935-1943 9 p.Research output: Contribution to journal › Article › peer-review
22 Scopus citations -
The convergent roles of tapasin and HLA-DM in antigen presentation
Sadegh-Nasseri, S., Chen, M., Narayan, K. & Bouvier, M., Mar 2008, In: Trends in Immunology. 29, 3, p. 141-147 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access38 Scopus citations -
2007
HLA-DM targets the hydrogen bond between the histidine at position β81 and peptide to dissociate HLA-DR-peptide complexes
Narayan, K., Chou, C. L., Kim, A. R., Hartman, I. Z., Dalai, S., Khoruzhenko, S. & Sadegh-Nasseri, S., Jan 2007, In: Nature Immunology. 8, 1, p. 92-100 9 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2004
The Magnitude of TCR Engagement is a Critical Predictor of T Cell Anergy or Activation
Mirshahidi, S., Korb Ferris, L. C. & Sadegh-Nasseri, S., May 1 2004, In: Journal of Immunology. 172, 9, p. 5346-5355 10 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2003
Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anesthetics
Fang, M., Tao, Y. X., He, F., Zhang, M., Levine, C. F., Mao, P., Tao, F., Chou, C. L., Sadegh-Nasseri, S. & Johns, R. A., Sep 19 2003, In: Journal of Biological Chemistry. 278, 38, p. 36669-36675 7 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2001
Anergy in peripheral memory CD4+ T cells induced by low avidity engagement of T cell receptor
Mirshahidi, S., Huang, C. & Sadegh-Nasseri, S., Sep 17 2001, In: Journal of Experimental Medicine. 194, 6, p. 719-731 13 p.Research output: Contribution to journal › Article › peer-review
Open Access62 Scopus citations -
2000
Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1
Sato, A. K., Zarutskie, J. A., Rushe, M. M., Lomakin, A., Natarajan, S. K., Sadegh-Nasseri, S., Benedek, G. B. & Stern, L. J., Jan 21 2000, In: Journal of Biological Chemistry. 275, 3, p. 2165-2173 9 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Scopus citations -
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II
Chou, C. L. & Sadegh-Nasseri, S., Dec 18 2000, In: Journal of Experimental Medicine. 192, 12, p. 1697-1706 10 p.Research output: Contribution to journal › Article › peer-review
Open Access97 Scopus citations -
1999
Induction of T cell anergy by low numbers of agonist ligands
Korb, L. C., Mirshahidi, S., Ramyar, K., Sadighi Akha, A. A. & Sadegh-Nasseri, S., Jun 1 1999, In: Journal of Immunology. 162, 11, p. 6401-6409 9 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1
Natarajan, S. K., Stern, L. J. & Sadegh-Nasseri, S., Mar 15 1999, In: Journal of Immunology. 162, 6, p. 3463-3470 8 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides
Natarajan, S. K., Assadi, M. & Sadegh-Nasseri, S., Apr 1 1999, In: Journal of Immunology. 162, 7, p. 4030-4036 7 p.Research output: Contribution to journal › Article › peer-review
82 Scopus citations -
1997
A recombinant single-chain human class II MHC molecule (HLA-DR1) as a covalently linked heterotrimer of α chain, β chain, and antigenic peptide, with immunogenicity in vitro and reduced affinity for bacterial superantigens
Zhu, X., Bavari, S., Ulrich, R., Sadegh-Nasseri, S., Ferrone, S., McHugh, L. & Mage, M., Aug 1997, In: European Journal of Immunology. 27, 8, p. 1933-1941 9 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
1996
Processing and presentation of endocytically acquired protein antigens by MHC class II and class I molecules
Germain, R. N., Castellino, F., Han, R., Reis E Sousa, C., Romagnoli, P., Sadegh-Nasseri, S. & Zhong, G. M., 1996, In: Immunological reviews. 151, p. 5-30 26 p.Research output: Contribution to journal › Review article › peer-review
86 Scopus citations -
Recombinant single chain human HLA-DR1 molecules as biologically active covalently linked heterotrimers of antigenic peptide, beta chain, and alpha chain
Zhu, X., Sadegh-Nasseri, S., Bavari, S., Ulrich, R. G. & Mage, M., 1996, In: FASEB Journal. 10, 6, p. A1175Research output: Contribution to journal › Article › peer-review