Rose Parkinson

2024

A phase II study of guadecitabine combined with irinotecan vs regorafenib or TAS-102 in irinotecan-refractory metastatic colorectal cancer patients

Lee, V., Parkinson, R., Zahurak, M., Cope, L., Cercek, A., Verheul, H., Gootjes, E., Lenz, H. J., Iqbal, S., Jones, P., Baylin, S., Rami, V., Ahuja, N., El Khoueiry, A. & Azad, N. S., May 15 2024, In: International Journal of Cancer. 154, 10, p. 1794-1801 8 p.

Research output: Contribution to journal › Article › peer-review

Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells

Wang, J., Gai, J., Zhang, T., Niu, N., Qi, H., Thomas, D. L., Li, K., Xia, T., Rodriguez, C., Parkinson, R., Durham, J., McPhaul, T., Narang, A. K., Anders, R. A., Osipov, A., Wang, H., He, J., Laheru, D. A., Herman, J. M., Lee, V., & 4 othersJaffee, E. M., Thompson, L., Zhu, Q. & Zheng, L., Feb 2024, In: Science Advances. 10, 6, eadk1827.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma

Heumann, T., Judkins, C., Li, K., Lim, S. J., Hoare, J., Parkinson, R., Cao, H., Zhang, T., Gai, J., Celiker, B., Zhu, Q., McPhaul, T., Durham, J., Purtell, K., Klein, R., Laheru, D., De Jesus-Acosta, A., Le, D. T., Narang, A., Anders, R., & 9 othersBurkhart, R., Burns, W., Soares, K., Wolfgang, C., Thompson, E., Jaffee, E., Wang, H., He, J. & Zheng, L., Dec 2023, In: Nature communications. 14, 1, 3650.

Research output: Contribution to journal › Article › peer-review

Open Access

A study of using epigenetic modulators to enhance response to pembrolizumab (MK-3475) in microsatellite stable advanced colorectal cancer

Baretti, M., Murphy, A. G., Zahurak, M., Gianino, N., Parkinson, R., Walker, R., Lopez-Vidal, T. Y., Zheng, L., Rosner, G., Ahuja, N., Kurt, S. & Azad, N. S., Dec 2023, In: Clinical Epigenetics. 15, 1, 74.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy

Li, K., Tandurella, J. A., Gai, J., Zhu, Q., Lim, S. J., Thomas, D. L., Xia, T., Mo, G., Mitchell, J. T., Montagne, J., Lyman, M., Danilova, L. V., Zimmerman, J. W., Kinny-Köster, B., Zhang, T., Chen, L., Blair, A. B., Heumann, T., Parkinson, R., Durham, J. N., & 11 othersNarang, A. K., Anders, R. A., Wolfgang, C. L., Laheru, D. A., He, J., Osipov, A., Thompson, E. D., Wang, H., Fertig, E. J., Jaffee, E. M. & Zheng, L., Nov 14 2022, In: Cancer cell. 40, 11, p. 1374-1391.e7

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Vaccine-induced intratumoral lymphoid aggregates correlate with survival following treatment with a neoadjuvant and adjuvant vaccine in patients with resectable pancreatic adenocarcinoma

Zheng, L., Ding, D., Edil, B. H., Judkins, C., Durham, J. N., Thomas, D. L., Bever, K. M., Mo, G., Solt, S. E., Hoare, J. A., Bhattacharya, R., Zhu, Q., Osipov, A., Onner, B., Purtell, K. A., Cai, H., Parkinson, R., Hacker-Prietz, A., Herman, J. M., Le, D. T., & 17 othersAzad, N. S., de Jesus-Acosta, A. M. C., Blair, A. B., Kim, V., Soares, K. C., Manos, L., Cameron, J. L., Makary, M. A., Weiss, M. J., Schulick, R. D., He, J., Wolfgang, C. L., Thompson, E. D., Anders, R. A., Sugar, E., Jaffee, E. M. & Laheru, D. A., Mar 1 2021, In: Clinical Cancer Research. 27, 5, p. 1278-1286 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2020

A Phase II Study of Allogeneic GM-CSF–Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer

Wu, A. A., Bever, K. M., Ho, W. J., Fertig, E. J., Niu, N., Zheng, L., Parkinson, R. M., Durham, J. N., Onners, B., Ferguson, A. K., Wilt, C., Ko, A. H., Wang-Gillam, A., Laheru, D. A., Anders, R. A., Thompson, E. D., Sugar, E. A., Jaffee, E. M. & Le, D. T., Oct 1 2020, In: Clinical Cancer Research. 26, 19, p. 5129-5139 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

A phase i trial of the VEGF receptor tyrosine kinase inhibitor pazopanib in combination with the MEK inhibitor trametinib in advanced solid tumors and differentiated thyroid cancers

Kurzrock, R., Ball, D. W., Zahurak, M. L., Nelkin, B. D., Subbiah, V., Ahmed, S., O'Connor, A., Karunsena, E., Parkinson, R. M., Bishop, J. A., Ha, Y., Sharma, R., Gocke, C. D., Zinner, R., Rudek, M. A., Sherman, S. I. & Azad, N. S., Sep 15 2019, In: Clinical Cancer Research. 25, 18, p. 5475-5484 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2018

A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan

Lee, V., Wang, J., Zahurak, M., Gootjes, E., Verheul, H. M., Parkinson, R., Kerner, Z., Sharma, A., Rosner, G., De Jesus-Acosta, A., Laheru, D., Le, D. T., Oganesian, A., Lilly, E., Brown, T., Jones, P., Baylin, S., Ahuja, N. & Azad, N., Dec 15 2018, In: Clinical Cancer Research. 24, 24, p. 6160-6167 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

2014

Egr3 induces a Th17 response by promoting the development of γδ T cells

Parkinson, R. M., Collins, S. L., Horton, M. R. & Powell, J. D., Jan 24 2014, In: PloS one. 9, 1, e87265.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2010

Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo

Kutzler, M. A., Kraynyak, K. A., Nagle, S. J., Parkinson, R. M., Zharikova, D., Chattergoon, M., Maguire, H., Muthumani, K., Ugen, K. & Weiner, D. B., Jan 2010, In: Gene Therapy. 17, 1, p. 72-82 11 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

2008

Therapeutic vaccination with simian immunodeficiency virus (SIV)-DNA+IL-12 or IL-15 induces distinct CD8 memory subsets in SIV-infected macaques

Halwani, R., Boyer, J. D., Yassine-Diab, B., Haddad, E. K., Robinson, T. M., Kumar, S., Parkinson, R., Wu, L., Sidhu, M. K., Phillipson-Weiner, R., Pavlakis, G. N., Felber, B. K., Lewis, M. G., Shen, A., Siliciano, R. F., Werner, D. B. & Sekaly, R. P., 2008, In: Journal of Immunology. 180, 12, p. 7969-7979 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

2007

Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid

Boyer, J. D., Robinson, T. M., Kutzler, M. A., Vansant, G., Hokey, D. A., Kumar, S., Parkinson, R., Wu, L., Sidhu, M. K., Pavlakis, G. N., Felber, B. K., Brown, C., Silvera, P., Lewis, M. G., Monforte, J., Waldmann, T. A., Eldridge, J. & Weiner, D. B., Nov 20 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 47, p. 18648-18653 6 p.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

2006

Initiation of antiretroviral therapy during chronic SIV infection leads to rapid reduction in viral loads and the level of T-cell immune response

Boyer, J. D., Kumar, S., Robinson, T., Parkinson, R., Wu, L., Lewis, M., Watkins, D. I. & Weiner, D. B., Aug 2006, In: Journal of medical primatology. 35, 4-5, p. 202-209 8 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Rhesus macaques with high levels of vaccine induced IFN-gamma producing cells better control viral set-point following challenge with SIV239

Boyer, J. D., Maciag, P. C., Parkinson, R., Wu, L., Lewis, M. G., Weiner, D. B. & Paterson, Y., May 22 2006, In: Vaccine. 24, 21, p. 4498-4502 5 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2005

Analytical and biological characterization of supercoiled plasmids purified by various chromatographic techniques

Tumanova, I., Boyer, J., Ausar, S. F., Burzynski, J., Rosencrance, D., White, J., Scheidel, J., Parkinson, R., Maguire, H., Middaugh, C. R., Weiner, D. & Green, A. P., Dec 2005, In: DNA and Cell Biology. 24, 12, p. 819-831 13 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help

Kutzler, M. A., Robinson, T. M., Chattergoon, M. A., Choo, D. K., Choo, A. Y., Choe, P. Y., Ramanathan, M. P., Parkinson, R., Kudchodkar, S., Tamura, Y., Sidhu, M., Roopchand, V., Kim, J. J., Pavlakis, G. N., Felber, B. K., Waldmann, T. A., Boyer, J. D. & Weiner, D. B., Jul 1 2005, In: Journal of Immunology. 175, 1, p. 112-123 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

153 Scopus citations

SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques

Boyer, J. D., Robinson, T. M., Kutzler, M. A., Parkinson, R., Calarota, S. A., Sidhu, M. K., Muthumani, K., Lewis, M., Pavlakis, G., Felber, B. & Weiner, D., Oct 2005, In: Journal of medical primatology. 34, 5-6 SPEC. ISS., p. 262-270 9 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Rose Parkinson

Research output

Search results