Research output per year
Research output per year
- 1 - 50 out of 322 results
Search results
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2024
Association of diastolic blood pressure with coronary perfusion pressure during resuscitation in pediatric swine
Sorcher, J. L., Santos, P., Adams, S., Kulikowicz, E., Vaidya, D., Lee, J. K., Hunt, E. A., Koehler, R. C., Shaffner, D. H. & O’Brien, C. E., 2024, (Accepted/In press) In: Pediatric research.Research output: Contribution to journal › Article › peer-review
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Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial
Morais, A., Imai, T., Jin, X., Locascio, J. J., Boisserand, L., Herman, A. L., Chauhan, A., Lamb, J., Nagarkatti, K., Diniz, M. A., Kumskova, M., Dhanesha, N., Kamat, P. K., Khan, M. B., Dhandapani, K. M., Patel, R. B., Sutariya, B., Shi, Y., van Leyen, K. & Kimberly, W. T. & 8 others, , Aug 16 2024, In: Circulation research. 135, 5, p. 575-592 18 p.Research output: Contribution to journal › Article › peer-review
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Neuroprotection provided by hypothermia initiated with high transnasal flow with ambient air in a model of pediatric cardiac arrest
Yang, Z. J., Hopkins, C. D., Santos, P. T., Adams, S., Kulikowicz, E., Lee, J. K., Tandri, H. & Koehler, R. C., Sep 2024, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 327, 3, p. R304-R318Research output: Contribution to journal › Article › peer-review
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Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke
Kim, J. E., Lee, R. P., Yazigi, E., Atta, L., Feghali, J., Pant, A., Jain, A., Levitan, I., Kim, E., Patel, K., Kannapadi, N., Shah, P., Bibic, A., Hou, Z., Caplan, J. M., Gonzalez, L. F., Huang, J., Xu, R., Fan, J. & Tyler, B. & 8 others, , Feb 2024, In: Brain, Behavior, and Immunity. 116, p. 160-174 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke
Lyden, P. D., Diniz, M. A., Bosetti, F., Lamb, J., Nagarkatti, K. A., Rogatko, A., Kim, S., Cabeen, R. P., Koenig, J. I., Akhter, K., Arbab, A. S., Avery, B. D., Beatty, H. E., Bibic, A., Cao, S., Boisserand, L. S. B., Chamorro, A., Chauhan, A., Diaz-Perez, S. & Dhandapani, K. & 29 others, , Sep 20 2023, In: Science translational medicine. 15, 714, eadg8656.Research output: Contribution to journal › Article › peer-review
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Embolic occlusion of internal carotid artery in conscious rats: Immediate effects of cerebral ischemia
Toung, T. J. K., Mehr, N., Mirski, M. & Koehler, R. C., Feb 2023, In: Physiological Reports. 11, 4, e15613.Research output: Contribution to journal › Article › peer-review
Open Access -
Hypothermic Protection in Neocortex Is Topographic and Laminar, Seizure Unmitigating, and Partially Rescues Neurons Depleted of RNA Splicing Protein Rbfox3/NeuN in Neonatal Hypoxic-Ischemic Male Piglets
Primiani, C. T., Lee, J. K., O’Brien, C. E., Chen, M. W., Perin, J., Kulikowicz, E., Santos, P., Adams, S., Lester, B., Rivera-Diaz, N., Olberding, V., Niedzwiecki, M. V., Ritzl, E. K., Habela, C. W., Liu, X., Yang, Z. J., Koehler, R. C. & Martin, L. J., Oct 2023, In: Cells. 12, 20, 2454.Research output: Contribution to journal › Article › peer-review
Open Access -
Importance of Control Groups for Evaluating Long-Term Behavioral and Cognitive Outcomes of Controlled Cortical Impact in Immature Rats
El-Demerdash, N., Pan, T., Choi, O., Saraswati, M., Koehler, R. C., Robertson, C. L. & Savonenko, A., Jun 1 2023, In: Journal of neurotrauma. 40, 11-12, p. 1197-1215 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes
Han, R., Lan, X., Han, Z., Ren, H., Aafreen, S., Wang, W., Hou, Z., Zhu, T., Qian, A., Han, X., Koehler, R. C. & Liu, G., Oct 2023, In: Biomaterials. 301, 122277.Research output: Contribution to journal › Article › peer-review
Open Access -
Polynitroxylated PEGylated hemoglobin protects pig brain neocortical gray and white matter after traumatic brain injury and hemorrhagic shock
Wang, J., Shi, Y., Cao, S., Liu, X., Martin, L. J., Simoni, J., Soltys, B. J., Hsia, C. J. C. & Koehler, R. C., 2023, In: Frontiers in Medical Technology. 5, 1074643.Research output: Contribution to journal › Article › peer-review
Open Access -
Rapid, selective and homogeneous brain cooling with transnasal flow of ambient air for pediatric resuscitation
Koehler, R. C., Reyes, M., Hopkins, C. D., Armstrong, J. S., Cao, S., Kulikowicz, E., Lee, J. K. & Tandri, H., Nov 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 11, p. 1842-1856 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Amide Proton Transfer-Weighted Magnetic Resonance Imaging for Detecting Severity and Predicting Outcome after Traumatic Brain Injury in Rats
Dong, Y., Gu, Y., Lu, J., Wan, J., Jiang, S., Koehler, R. C., Wang, J. & Zhou, J., 2022, In: Neurotrauma Reports. 3, 1, p. 261-275 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Comparison of different metrics of cerebral autoregulation in association with major morbidity and mortality after cardiac surgery
Liu, X., Donnelly, J., Brady, K. M., Akiyoshi, K., Bush, B., Koehler, R. C., Lee, J. K., Hogue, C. W., Czosnyka, M., Smielewski, P. & Brown, C. H., Jul 2022, In: British journal of anaesthesia. 129, 1, p. 22-32 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Interleukin-10 deficiency aggravates traumatic brain injury in male but not female mice
Gu, Y., Dong, Y., Wan, J., Ren, H., Koehler, R. C. & Wang, J., Sep 2022, In: Experimental Neurology. 355, 114125.Research output: Contribution to journal › Article › peer-review
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Neuroprotection in the Striatum of Hypoxic-Ischemic Piglets by Simultaneous Inhibition of Dopamine D1 and Adenosine A2AReceptors
Wang, B., Kulikowicz, E., Koehler, R. C. & Yang, Z. J., May 1 2022, In: Neonatology. 119, 3, p. 354-360 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Photoacoustic assessment of the fetal brain and placenta as a method of non-invasive antepartum and intrapartum monitoring
Kang, J., Koehler, R. C., Graham, E. M. & Boctor, E., Jan 2022, In: Experimental Neurology. 347, 113898.Research output: Contribution to journal › Article › peer-review
Open Access -
The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results
Lyden, P. D., Bosetti, F., Diniz, M. A., Rogatko, A., Koenig, J. I., Lamb, J., Nagarkatti, K. A., Cabeen, R. P., Hess, D. C., Kamat, P. K., Khan, M. B., Wood, K., Dhandapani, K., Arbab, A. S., Leira, E. C., Chauhan, A. K., Dhanesha, N., Patel, R. B., Kumskova, M. & Thedens, D. & 23 others, , May 1 2022, In: Stroke. 53, 5, p. 1802-1812 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
20-HETE Participates in Intracerebral Hemorrhage-Induced Acute Injury by Promoting Cell Ferroptosis
Han, R., Wan, J., Han, X., Ren, H., Falck, J. R., Munnuri, S., Yang, Z. J. & Koehler, R. C., Nov 12 2021, In: Frontiers in Neurology. 12, 763419.Research output: Contribution to journal › Article › peer-review
Open Access -
Analysis of glucose metabolism by 18F-FDG-PET imaging and glucose transporter expression in a mouse model of intracerebral hemorrhage
Han, X., Ren, H., Nandi, A., Fan, X. & Koehler, R. C., Dec 2021, In: Scientific reports. 11, 1, 10885.Research output: Contribution to journal › Article › peer-review
Open Access -
Combining hypothermia and oleuropein subacutely protects subcortical white matter in a swine model of neonatal hypoxic-ischemic encephalopathy
Lee, J. K., Santos, P. T., Chen, M. W., O’Brien, C. E., Kulikowicz, E., Adams, S., Hardart, H., Koehler, R. C. & Martin, L. J., 2021, In: Journal of neuropathology and experimental neurology. 80, 2, p. 182-198 17 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Determining Thresholds for Three Indices of Autoregulation to Identify the Lower Limit of Autoregulation During Cardiac Surgery∗
Liu, X., Akiyoshi, K., Nakano, M., Brady, K., Bush, B., Nadkarni, R., Venkataraman, A., Koehler, R. C., Lee, J. K., Hogue, C. W., Czosnyka, M., Smielewski, P. & Brown, C. H., Apr 1 2021, In: Critical care medicine. 49, 4, p. 650-660 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Fractional anisotropy from diffusion tensor imaging correlates with acute astrocyte and myelin swelling in neonatal swine models of excitotoxic and hypoxic-ischemic brain injury
Lee, J. K., Liu, D., Jiang, D., Kulikowicz, E., Tekes, A., Liu, P., Qin, Q., Koehler, R. C., Aggarwal, M., Zhang, J. & Martin, L. J., Jul 1 2021, In: Journal of Comparative Neurology. 529, 10, p. 2750-2770 21 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Microglia-derived interleukin-10 accelerates post-intracerebral hemorrhage hematoma clearance by regulating CD36
Li, Q., Lan, X., Han, X., Durham, F., Wan, J., Weiland, A., Koehler, R. C. & Wang, J., May 2021, In: Brain, Behavior, and Immunity. 94, p. 437-457 21 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Nrf2-BDNF-TrkB pathway contributes to cortical hemorrhage-induced depression, but not sex differences
Ren, H., Han, R., Liu, X., Wang, L., Koehler, R. C. & Wang, J., Dec 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 12, p. 3288-3301 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded-O2 study in piglets
Jiang, D., Koehler, R. C., Liu, X., Kulikowicz, E., Lee, J. K., Lu, H. & Liu, P., Sep 2021, In: Magnetic resonance in medicine. 86, 3, p. 1445-1453 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulation of the Cerebral Circulation During Development
Koehler, R. C., Oct 2021, In: Comprehensive Physiology. 11, 4, p. 2371-2432 62 p.Research output: Contribution to journal › Article › peer-review
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Sulforaphane Protects Piglet Brains from Neonatal Hypoxic-Ischemic Injury
Wang, B., Kulikowicz, E., Lee, J. K., Koehler, R. C. & Yang, Z. J., Feb 2021, In: Developmental Neuroscience. 42, 2-4, p. 124-134 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Targeting the mitochondrial permeability transition pore for neuroprotection in a piglet model of neonatal hypoxic-ischemic encephalopathy
Chen, M. W., Santos, P., Kulikowicz, E., Koehler, R. C., Lee, J. K. & Martin, L. J., Jun 2021, In: Journal of neuroscience research. 99, 6, p. 1550-1564 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The association of bispectral index values and metrics of cerebral perfusion during cardiopulmonary bypass
Liu, X., Nakano, M., Yamaguchi, A., Bush, B., Akiyoshi, K., Lee, J. K., Koehler, R. C., Hogue, C. W. & Brown, C. H., Nov 2021, In: Journal of Clinical Anesthesia. 74, 110395.Research output: Contribution to journal › Article › peer-review
Open Access -
Transcranial photoacoustic characterization of neurovascular physiology during early-stage photothrombotic stroke in neonatal piglets in vivo
Kang, J., Liu, X., Cao, S., Zeiler, S. R., Graham, E. M., Boctor, E. & Koehler, R. C., Dec 2021, In: Journal of neural engineering. 18, 6, 065001.Research output: Contribution to journal › Article › peer-review
Open Access -
Use of an end-tidal carbon dioxide-guided algorithm during cardiopulmonary resuscitation improves short-term survival in paediatric swine
O'Brien, C. E., Santos, P., Kulikowicz, E., Adams, S., Lee, J. K., Hunt, E. A., Koehler, R. C. & Shaffner, D. H., Dec 2021, In: Resuscitation Plus. 8, 100174.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Administration of a 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor Improves Outcome in a Rat Model of Pediatric Traumatic Brain Injury
Shu, S., Zhang, Z., Spicer, D., Kulikowicz, E., Hu, K., Babapoor-Farrokhran, S., Kannan, S., Koehler, R. C. & Robertson, C. L., Feb 1 2020, In: Developmental Neuroscience. 41, 3-4, p. 166-176 11 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Comparison of wavelet and correlation indices of cerebral autoregulation in a pediatric swine model of cardiac arrest
Liu, X., Hu, X., Brady, K. M., Koehler, R., Smielewski, P., Czosnyka, M., Donnelly, J. & Lee, J. K., Dec 1 2020, In: Scientific reports. 10, 1, 5926.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Mean Diffusivity in Striatum Correlates With Acute Neuronal Death but Not Lesser Neuronal Injury in a Pilot Study of Neonatal Piglets With Encephalopathy
Lee, J. K., Liu, D., Raven, E. P., Jiang, D., Liu, P., Qin, Q., Kulikowicz, E., Santos, P. T., Adams, S., Zhang, J., Koehler, R. C., Martin, L. J. & Tekes, A., Oct 1 2020, In: Journal of Magnetic Resonance Imaging. 52, 4, p. 1216-1226 11 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine
O’Brien, C. E., Santos, P. T., Kulikowicz, E., Lee, J. K., Koehler, R. C. & Martin, L. J., Dec 1 2020, In: BMC Neuroscience. 21, 1, 43.Research output: Contribution to journal › Article › peer-review
Open Access -
Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock
Seno, S., Wang, J., Cao, S., Saraswati, M., Park, S., Simoni, J., Ma, L., Soltys, B., Hsia, C. J. C., Koehler, R. C. & Robertson, C. L., May 13 2020, In: BMC Neuroscience. 21, 1, 22.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The use of pressure-controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest
Lapid, F. M., O'Brien, C. E., Kudchadkar, S. R., Lee, J. K., Hunt, E. A., Koehler, R. C. & Shaffner, D. H., Apr 1 2020, In: Paediatric anaesthesia. 30, 4, p. 462-468 7 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2019
20-HETE synthesis inhibition promotes cerebral protection after intracerebral hemorrhage without inhibiting angiogenesis
Han, X., Zhao, X., Lan, X., Li, Q., Gao, Y., Liu, X., Wan, J., Yang, Z., Chen, X., Zang, W., Guo, A. M., Falck, J. R., Koehler, R. C. & Wang, J., Aug 1 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 8, p. 1531-1543 13 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Association of diastolic blood pressure with survival during paediatric cardiopulmonary resuscitation
O'Brien, C. E., Santos, P. T., Reyes, M., Adams, S., Hopkins, C. D., Kulikowicz, E., Hamrick, J. L., Hamrick, J. T., Lee, J. K., Kudchadkar, S. R., Hunt, E. A., Koehler, R. C. & Shaffner, D. H., Oct 2019, In: Resuscitation. 143, p. 50-56 7 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Biodistribution of Glial Progenitors in a Three Dimensional-Printed Model of the Piglet Cerebral Ventricular System
Srivastava, R. K., Jablonska, A., Chu, C., Gregg, L., Bulte, J. W. M., Koehler, R. C., Walczak, P. & Janowski, M., Apr 15 2019, In: Stem Cells and Development. 28, 8, p. 515-527 13 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Comparison of Frequency-and Time-Domain Autoregulation and Vasoreactivity Indices in a Piglet Model of Hypoxia-Ischemia and Hypothermia
Govindan, R. B., Brady, K. M., Massaro, A. N., Perin, J., Jennings, J. M., DuPlessis, A. J., Koehler, R. C. & Lee, J. K., Jul 1 2019, In: Developmental Neuroscience. 40, 5-6, p. 547-559 13 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery
O'Brien, C. E., Santos, P. T., Kulikowicz, E., Reyes, M., Koehler, R. C., Martin, L. J. & Lee, J. K., Sep 1 2019, In: Developmental Neuroscience. 41, 1-2, p. 17-33 17 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition
Singh, R., Kulikowicz, E., Santos, P. T., Koehler, R. C., Martin, L. J. & Lee, J. K., Sep 2 2019, In: Behavioural Brain Research. 369, 111921.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
The Effect of Asphyxia Arrest Duration on a Pediatric End-Tidal co 2-Guided Chest Compression Delivery Model
Hamrick, J. L., Hamrick, J. T., O'Brien, C. E., Reyes, M., Santos, P. T., Heitmiller, S. E., Kulikowicz, E., Lee, J. K., Kudchadkar, S. R., Koehler, R. C., Hunt, E. A. & Shaffner, D. H., Jul 1 2019, In: Pediatric Critical Care Medicine. 20, 7, p. e352-e361Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Therapeutic hypothermia promotes cerebral blood flow recovery and brain homeostasis after resuscitation from cardiac arrest in a rat model
Wang, Q., Miao, P., Modi, H. R., Garikapati, S., Koehler, R. C. & Thakor, N. V., Oct 1 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 10, p. 1961-1973 13 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Traumatic Injury Leads to Inflammation and Altered Tryptophan Metabolism in the Juvenile Rabbit Brain
Zhang, Z., Rasmussen, L., Saraswati, M., Koehler, R. C., Robertson, C. & Kannan, S., Jan 1 2019, In: Journal of neurotrauma. 36, 1, p. 74-86 13 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
2018
Abdominal near-infrared spectroscopy in a piglet model of gastrointestinal hypoxia produced by graded hypoxia or superior mesenteric artery ligation
Chen, M. W., Reyes, M., Kulikowicz, E., Martin, L., Hackam, D. J., Koehler, R. C. & Lee, J. K., Jun 1 2018, In: Pediatric research. 83, 6, p. 1172-1181 10 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Cerebral Autoregulation and Conventional and Diffusion Tensor Imaging Magnetic Resonance Imaging in Neonatal Hypoxic-Ischemic Encephalopathy
Carrasco, M., Perin, J., Jennings, J. M., Parkinson, C., Gilmore, M. M., Chavez-Valdez, R., Massaro, A. N., Koehler, R. C., Northington, F. J., Tekes, A. & Lee, J. K., May 2018, In: Pediatric Neurology. 82, p. 36-43 8 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Pilot study to compare the use of end-tidal carbon dioxide–guided and diastolic blood pressure–guided chest compression delivery in a swine model of neonatal asphyxial cardiac arrest
O’Brien, C. E., Reyes, M., Santos, P. T., Heitmiller, S. E., Kulikowicz, E., Kudchadkar, S. R., Lee, J. K., Hunt, E. A., Koehler, R. C. & Shaffner, D. H., Oct 1 2018, In: Journal of the American Heart Association. 7, 19, e009728.Research output: Contribution to journal › Article › peer-review
Open Access -
Proteasome biology is compromised in white matter after asphyxic cardiac arrest in neonatal piglets
Santos, P. T., O’brien, C. E., Chen, M. W., Hopkins, C. D., Adams, S., Kulikowicz, E., Singh, R., Koehler, R. C., Martin, L. J. & Lee, J. K., Oct 1 2018, In: Journal of the American Heart Association. 7, 20, e009415.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations