Research output per year
Research output per year
- 41 results
Search results
-
2025
Partially differentiated ileal and distal-colonic human F508del-cystic fibrosis-enteroids secrete fluid in response to forskolin and linaclotide
Rong, Y., Zhang, Z., de Jonge, H. R., Lin, R., Yu, H., Sarker, R., Boffelli, D., Zwick, R. K., Klein, O. D., Tse, C. M., Donowitz, M. & Singh, V., May 16 2025, In: iScience. 28, 5, 112453.Research output: Contribution to journal › Article › peer-review
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2024
COVID-19 Diarrhea is Inflammatory, Caused by Direct Viral Effects Plus Major Role of Virus-induced Cytokines
Donowitz, M., Tse, C. M., Sarker, R., Lin, R., Dokladny, K., Rawat, M., Horwitz, I., Ye, C. Y., McNamara, G., In, J., Kell, A., Guo, C., JuiTsai, S., Vong, T., Karaba, A., Singh, V., Sachithanandham, J., Pekosz, A., Cox, A. & Bradfute, S. & 3 others, , Jan 2024, In: CMGH. 18, 5, 101383.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity
Zachos, N. C., Vaughan, H., Sarker, R., Est-Witte, S., Chakraborty, M., Baetz, N. W., Yu, H., Yarov-Yarovoy, V., McNamara, G., Green, J. J., Tse, C. M. & Donowitz, M., Oct 2023, In: Gastroenterology. 165, 4, p. 986-998.e11Research output: Contribution to journal › Article › peer-review
Open Access -
SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca21-dependent manner by cAMP and ATP in intestinal epithelial cells
Sarker, R., Lin, R., Singh, V., Donowitz, M. & Tse, C. M., Jun 2023, In: American Journal of Physiology - Cell Physiology. 324, 6, p. C1263-C1273Research output: Contribution to journal › Article › peer-review
Open Access -
The Air–Liquid Interface Reorganizes Membrane Lipids and Enhances the Recruitment of Slc26a3 to Lipid-Rich Domains in Human Colonoid Monolayers
Tse, C., Zhang, Z., Lin, R., Sarker, R., Donowitz, M. & Singh, V., May 2023, In: International journal of molecular sciences. 24, 9, 8273.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity
Sarker, R., Tse, C. M., Lin, R., McNamara, G., Singh, V. & Donowitz, M., 2022, In: Cellular Physiology and Biochemistry. 56, 1, p. 39-49 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity
Tse, C. M., Yin, J., Singh, V., Sarker, R., Lin, R., Verkman, A. S., Turner, J. R. & Donowitz, M., Jan 1 2019, In: CMGH. 7, 3, p. 641-653 13 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea
Duan, T., Cil, O., Tse, C. M., Sarker, R., Lin, R., Donowitz, M. & Verkman, A. S., Oct 1 2019, In: FASEB Journal. 33, 10, p. 10924-10934 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: Differences in signaling in mouse small intestine and Caco-2 cells
Chen, T., Lin, R., Avula, L., Sarker, R., Yang, J., Cha, B., Tse, C. M., McNamara, G., Seidler, U., Waldman, S., Snook, A., Bijvelds, M. J. C., De Jonge, H. R., Li, X. & Donowitz, M., 2019, In: American Journal of Physiology - Cell Physiology. 317, 4, p. C737-C748Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2017
A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands
Yin, J., Tse, C., Cha, B., Sarker, R., Zhu, X. C., Walentinsson, A., Greasley, P. J. & Donowitz, M., 2017, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 2, p. G129-G137Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class i PDZ-binding motifs
Cha, B., Yang, J., Singh, V., Zachos, N., Sarker, R. I., Chen, T. E., Chakraborty, M., Tse, C. & Donowitz, M., May 19 2017, In: Journal of Biological Chemistry. 292, 20, p. 8279-8290 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes
Sarker, R., Cha, B., Kovbasnjuk, O. N., Cole, R., Gabelli, S. B., Tse, C. & Donowitz, M., Jul 1 2017, In: Molecular biology of the cell. 28, 13, p. 1754-1767 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2015
Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: Identification of a multifunctional phosphorylation site
Chen, T., Kocinsky, H. S., Cha, B., Murtazina, R., Yang, J., Tse, C., Singh, V., Cole, R., Aronson, P. S., De Jonge, H., Sarker, R. & Donowitz, M., Jan 23 2015, In: Journal of Biological Chemistry. 290, 4, p. 1952-1965 14 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity
Zhu, X. C., Sarker, R., Horton, J. R., Chakraborty, M., Chen, T. E., Ming Tse, C., Cha, B. & Donowitz, M., Jun 1 2015, In: American Journal of Physiology - Cell Physiology. 308, 9, p. C758-C766Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea
Janecke, A. R., Heinz-Erian, P., Yin, J., Petersen, B. S., Franke, A., Lechner, S., Fuchs, I., Melancon, S., Uhlig, H. H., Travis, S., Marinier, E., Perisic, V., Ristic, N., Gerner, P., Booth, I. W., Wedenoja, S., Baumgartner, N., Vodopiutz, J., Frechette-Duval, M. C. & De Lafollie, J. & 13 others, , Dec 1 2015, In: Human molecular genetics. 24, 23, p. 6614-6623 10 p.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3
Singh, V., Yang, J., Cha, B., Chen, T. E., Sarker, R., Yin, J., Avula, L. R., Tse, C. & Donowitz, M., Jun 1 2015, In: Molecular biology of the cell. 26, 11, p. 2030-2043 14 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity
Yang, J., Sarker, R., Singh, V., Sarker, P., Yin, J., Chen, T. E., Chaerkady, R., Li, X., Tse, C. M. & Donowitz, M., Aug 15 2015, In: Biochemical Journal. 470, 1, p. 77-90 14 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2014
AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal Stimulatory complex: Role of a novel Ser-rich NHE3 C-Terminal motif in NHE3 activity and trafficking
Singh, V., Lin, R., Yang, J., Cha, B., Sarker, R., Tse, C. & Donowitz, M., Feb 28 2014, In: Journal of Biological Chemistry. 289, 9, p. 5449-5461 13 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
Mroz, M. S., Keating, N., Ward, J. B., Sarker, R., Amu, S., Aviello, G., Donowitz, M., Fallon, P. G. & Keely, S. J., May 1 2014, In: Gut. 63, 5, p. 808-817 10 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling
Cha, B., Chen, T., Sarker, R., Yang, J., Raben, D., Tse, C., Kovbasnjuk, O. N. & Donowitz, M., Jul 1 2014, In: American Journal of Physiology - Cell Physiology. 307, 1, p. C55-C65Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells
Chen, T., Hubbard, A., Murtazina, R., Price, J., Yang, J., Cha, B., Sarker, R. & Donowitz, M., 2014, In: Journal of cell science. 127, 16, p. 3535-3545 11 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol
Yang, J., Singh, V., Chen, T. E., Sarker, R., Xiong, L., Cha, B., Jin, S., Li, X., Ming Tse, C., Zachos, N. C. & Donowitz, M., 2014, In: Journal of Biological Chemistry. 289, 29, p. 20039-20053 15 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2013
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells
Yang, J., Singh, V., Cha, B., Chen, T. E., Sarker, R., Murtazina, R., Jin, S., Zachos, N., Patterson, G. H., Tse, C., Kovbasnjuk, O. N., Li, X. & Donowitz, M., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 16960-16974 15 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2012
Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na +/H + exchanger 3 (NHE3) by a NHERF2 protein-dependent process
Zizak, M., Chen, T., Bartonicek, D., Sarker, R., Zachos, N., Cha, B., Kovbasnjuk, O. N., Korac, J., Mohan, S., Cole, R., Chen, Y., Tse, C. & Donowitz, M., Apr 13 2012, In: Journal of Biological Chemistry. 287, 16, p. 13442-13456 15 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2011
D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2dependent process
Lin, R., Murtazina, R., Cha, B., Chakraborty, M., Sarker, R., Chen, T., Lin, Z., Hogema, B. M., De Jonge, H. R., Seidler, U., Turner, J. R., Li, X., Kovbasnjuk, O. & Donowitz, M., Feb 2011, In: Gastroenterology. 140, 2, p. 560-571 12 p.Research output: Contribution to journal › Article › peer-review
Open Access69 Scopus citations -
Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli
Zhu, X., Cha, B., Zachos, N., Sarker, R., Chakraborty, M., Chen, T. E., Kovbasnjuk, O. N. & Donowitz, M., Oct 7 2011, In: Journal of Biological Chemistry. 286, 40, p. 34486-34496 11 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity
Sarker, R., Valkhoff, V. E., Zachos, N., Lin, R., Cha, B., Chen, T. E., Guggino, S. E., Zizak, M., de Jonge, H., Hogema, B. & Donowitz, M., Apr 2011, In: American Journal of Physiology - Cell Physiology. 300, 4, p. C771-C782Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
2010
NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region
Mohan, S., Tse, C. M., Gabelli, S. B., Sarker, R., Cha, B., Fahie, K., Nadella, M., Zachos, N. C., Tu-Sekine, B., Raben, D., Amzel, L. M. & Donowitz, M., Nov 5 2010, In: Journal of Biological Chemistry. 285, 45, p. 34566-34578 13 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid
Cha, B., Zhu, X. C., Chen, W., Jones, M., Ryoo, S., Zachos, N., Chen, T. E., Lin, R., Sarker, R., Kenworthy, A. K., Tse, C., Kovbasnjuk, O. N. & Donowitz, M., Jul 15 2010, In: Journal of cell science. 123, 14, p. 2434-2443 10 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2009
NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells
Zachos, N., Li, X., Kovbasnjuk, O. N., Hogema, B., Sarker, R., Lee, L. J., Li, M., de Jonge, H. & Donowitz, M., Aug 28 2009, In: Journal of Biological Chemistry. 284, 35, p. 23708-23718 11 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Phospholipase C-γ binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity
Zachos, N., van Rossum, D. B., Li, X., Caraveo, G., Sarker, R., Cha, B., Mohan, S., Desiderio, S., Patterson, R. L. & Donowitz, M., Jul 17 2009, In: Journal of Biological Chemistry. 284, 29, p. 19437-19444 8 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2008
Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3
Sarker, R., Grønborg, M., Cha, B., Mohan, S., Chen, Y., Pandey, A., Litchfield, D., Donowitz, M. & Li, X., Sep 2008, In: Molecular biology of the cell. 19, 9, p. 3859-3870 12 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
2006
Analysis of substrate-binding elements in OxlT, the oxalate:formate antiporter of Oxalobacter formigenes
Wang, X., Sarker, R. I. & Maloney, P. C., Aug 29 2006, In: Biochemistry. 45, 34, p. 10344-10350 7 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2002
Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction
Abe, K., Ohnishi, F., Yagi, K., Nakajima, T., Higuchi, T., Sano, M., Machida, M., Sarker, R. I. & Maloney, P. C., 2002, In: Journal of bacteriology. 184, 11, p. 2906-2913 8 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
Three-dimensional structure of a bacterial oxalate transporter
Hirai, T., Heymann, J. A. W., Shi, D., Sarker, R., Maloney, P. C. & Subramaniam, S., 2002, In: Nature Structural Biology. 9, 8, p. 597-600 4 p.Research output: Contribution to journal › Article › peer-review
181 Scopus citations -
2001
Na+/glutamine (Asparagine) cotransport by Staphylococcus lugdunensis and Corynebacterium amycolatum
Sarker, R. I. & Maloney, P. C., 2001, In: Journal of bacteriology. 183, 3, p. 1110-1112 3 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Projection structure and molecular architecture of OxlT, a bacterial membrane transporter
Heymann, J. A. W., Sarker, R., Hirai, T., Shi, D., Milne, J. L. S., Maloney, P. C. & Subramaniam, S., Aug 15 2001, In: EMBO Journal. 20, 16, p. 4408-4413 6 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Structure/function relationships in OxlT, the oxalate-formate transporter of Oxalobacter formigenes: Assignment of transmembrane helix 11 to the translocation pathway
Fu, D. X., Sarker, R. I., Abe, K., Bolton, E. & Maloney, P. C., Mar 23 2001, In: Journal of Biological Chemistry. 276, 12, p. 8753-8760 8 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
1997
Primary structure and properties of the Na+/glucose symporter (SglS) of Vibrio parahaemolyticus
Sarker, R. I., Ogawa, W., Shimamoto, T., Shimamoto, T. & Tsuchiya, T., 1997, In: Journal of bacteriology. 179, 5, p. 1805-1808 4 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
1996
Properties of a Na+/galactose(glucose) symport system in Vibrio parahaemolyticus
Sarker, R. I., Ogawa, W., Tsuda, M., Tanaka, S. & Tsuchiya, T., Mar 13 1996, In: Biochimica et Biophysica Acta - Biomembranes. 1279, 2, p. 149-156 8 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Sequence of a Na+/glucose symporter gene and its flanking regions of Vibrio parahaemolyticus
Sarker, R. I., Okabe, Y., Tsuda, M. & Tsuchiya, T., May 22 1996, In: Biochimica et Biophysica Acta - Biomembranes. 1281, 1, p. 1-4 4 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations