Philipp Oberdoerffer

Research output

Research output per year 2003 2003 2005 2008 2010 2012 2013 2015 2017 2018 2020 2023 2024 2024

• 21 Article
• 10 Review article
• 2 Short survey
• 1 Editorial
• 1 More
  • 1 Letter

Research output per year

Research output per year

Search results

• 2024

  AKTing on R Loops Makes for an ATRactive Target in Ovarian Cancer Therapy

  Ramanarayanan, V. & Oberdoerffer, P., Mar 15 2024, In: Cancer Research. 84, 6, p. 793-795 3 p.

  Research output: Contribution to journal › Article › peer-review

• Maintenance of genome integrity under physical constraints

  Soutoglou, E. & Oberdoerffer, P., Jan 2024, In: Chromosoma. 133, 1, p. 1-3 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access
• 2023

  Histone H2A variants: Diversifying chromatin to ensure genome integrity

  Oberdoerffer, P. & Miller, K. M., Feb 15 2023, In: Seminars in Cell and Developmental Biology. 135, p. 59-72 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Histones 100%
  • Chromatin 94%
  • Genome 72%
  • Protein Interaction Maps 33%
  • DNA 29%

• Loss of epigenetic information as a cause of mammalian aging

  Yang, J. H., Hayano, M., Griffin, P. T., Amorim, J. A., Bonkowski, M. S., Apostolides, J. K., Salfati, E. L., Blanchette, M., Munding, E. M., Bhakta, M., Chew, Y. C., Guo, W., Yang, X., Maybury-Lewis, S., Tian, X., Ross, J. M., Coppotelli, G., Meer, M. V., Rogers-Hammond, R., Vera, D. L., & 44 othersLu, Y. R., Pippin, J. W., Creswell, M. L., Dou, Z., Xu, C., Mitchell, S. J., Das, A., O'Connell, B. L., Thakur, S., Kane, A. E., Su, Q., Mohri, Y., Nishimura, E. K., Schaevitz, L., Garg, N., Balta, A. M., Rego, M. A., Gregory-Ksander, M., Jakobs, T. C., Zhong, L., Wakimoto, H., El Andari, J., Grimm, D., Mostoslavsky, R., Wagers, A. J., Tsubota, K., Bonasera, S. J., Palmeira, C. M., Seidman, J. G., Seidman, C. E., Wolf, N. S., Kreiling, J. A., Sedivy, J. M., Murphy, G. F., Green, R. E., Garcia, B. A., Berger, S. L., Oberdoerffer, P., Shankland, S. J., Gladyshev, V. N., Ksander, B. R., Pfenning, A. R., Rajman, L. A. & Sinclair, D. A., Jan 19 2023, In: Cell. 186, 2, p. 305-326.e27

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epigenomics 100%
  • Entropy 93%
  • Protein 47%
  • Yeasts 46%
  • Information Theory 42%

• Temozolomide Sensitizes ARID1A-Mutated Cancers to PARP Inhibitors

  Yu, Z. C., Li, T., Tully, E., Huang, P., Chen, C. N., Oberdoerffer, P., Gaillard, S., Shih, I. M. & Wang, T. L., Aug 2023, In: Cancer Research. 83, 16, p. 2750-2762 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(ADP-ribose) Polymerase Inhibitors 100%
  • Temozolomide 94%
  • DNA Repair 41%
  • Cell Cycle Checkpoints 29%
  • Heterografts 27%
• 2021

  Encounters in Three Dimensions: How Nuclear Topology Shapes Genome Integrity

  Sebastian, R., Aladjem, M. I. & Oberdoerffer, P., Oct 21 2021, In: Frontiers in Genetics. 12, 746380.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Chromatin 100%
  • DNA Repair 78%
  • Genome 76%
  • Biophysics 38%
  • DNA Breaks 34%
• 2020

  Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability

  Sebastian, R., Hosogane, E. K., Sun, E. G., Tran, A. D., Reinhold, W. C., Burkett, S., Sturgill, D. M., Gudla, P. R., Pommier, Y., Aladjem, M. I. & Oberdoerffer, P., Sep 3 2020, In: Molecular cell. 79, 5, p. 836-845.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • macroH2A histone 100%
  • Genomic Instability 57%
  • DNA Repair 48%
  • Epigenomics 46%
  • Anaphase 22%

• RNA: a double-edged sword in genome maintenance

  Zong, D., Oberdoerffer, P., Batista, P. J. & Nussenzweig, A., Nov 1 2020, In: Nature Reviews Genetics. 21, 11, p. 651-670 20 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genomic Instability 100%
  • Maintenance 95%
  • RNA 94%
  • Genome 92%
  • Chromosomal Instability 56%

• The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

  Human Tumor Atlas Network, Apr 16 2020, In: Cell. 181, 2, p. 236-249 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Ecosystem 100%
  • Atlases 90%
  • Biological Marker 75%
  • Time 30%
  • Neoplasms 27%
  49 Scopus citations
• 2019

  The macroH2A1.2 histone variant links ATRX loss to alternative telomere lengthening

  Kim, J., Sun, C., Tran, A. D., Chin, P. J., Ruiz, P. D., Wang, K., Gibbons, R. J., Gamble, M. J., Liu, Y. & Oberdoerffer, P., Mar 1 2019, In: Nature Structural and Molecular Biology. 26, 3, p. 213-219 7 p.

  Research output: Contribution to journal › Article › peer-review

  • macroH2A histone 100%
  • Telomere Homeostasis 77%
  • Histones 49%
  • Telomere 48%
  • Homologous Recombination 29%
• 2018

  Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions

  Kim, J., Sturgill, D., Sebastian, R., Khurana, S., Tran, A. D., Edwards, G. B., Kruswick, A., Burkett, S., Hosogane, E. K., Hannon, W. W., Weyemi, S., Bonner, W. M., Luger, K. & Oberdoerffer, P., Jan 4 2018, In: Molecular cell. 69, 1, p. 36-47.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • macroH2A histone 100%
  • Chromatin 65%
  • DNA Damage 64%
  • Histones 19%
  • Recombinational DNA Repair 13%
  31 Scopus citations

• SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

  Sun, J., He, X., Zhu, Y., Ding, Z., Dong, H., Feng, Y., Du, J., Wang, H., Wu, X., Zhang, L., Yu, X., Lin, A., McDonald, T., Zhao, D., Wu, H., Hua, W. K., Zhang, B., Feng, L., Tohyama, K., Bhatia, R., & 13 othersOberdoerffer, P., Chung, Y. J., Aplan, P. D., Boultwood, J., Pellagatti, A., Khaled, S., Kortylewski, M., Pichiorri, F., Kuo, Y. H., Carlesso, N., Marcucci, G., Jin, H. & Li, L., Sep 6 2018, In: Cell stem cell. 23, 3, p. 355-369.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myelodysplastic Syndromes 100%
  • Hematopoietic Stem Cells 87%
  • Stem Cells 65%
  • Maintenance 62%
  • Cell Self Renewal 10%

• The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth

  Kim, J., Oberdoerffer, P. & Khurana, S., May 4 2018, In: Molecular and Cellular Oncology. 5, 3, e1441629.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • macroH2A histone 100%
  • Histones 98%
  • Genome 71%
  • Growth 53%
  • DNA Repair 48%
• 2017

  Transcription-associated events affecting genomic integrity

  Sebastian, R. & Oberdoerffer, P., 2017, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 372, 1731, 20160288.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • R-Loop Structures 100%
  • DNA damage 91%
  • DNA Damage 81%
  • transcription (genetics) 69%
  • Genome 63%

• Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

  Liu, J., Kruswick, A., Dang, H., Tran, A. D., Kwon, S. M., Wang, X. W. & Oberdoerffer, P., Dec 1 2017, In: Nature communications. 8, 1, 137.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ubiquitin-Specific Proteases 100%
  • protease 99%
  • Cell Viability 66%
  • tumors 63%
  • DNA Repair 61%
• 2015

  A BRCA1-interacting lncRNA regulates homologous recombination

  Sharma, V., Khurana, S., Kubben, N., Abdelmohsen, K., Oberdoerffer, P., Gorospe, M. & Misteli, T., Nov 2015, In: EMBO Reports. 16, 11, p. 1520-1534 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Homologous Recombination 100%
  • Long Noncoding RNA 96%
  • RNA I 87%
  • DNA Damage 77%
  • Microarrays 31%

• Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability

  Kim, J., Sturgill, D., Tran, A. D., Sinclair, D. A. & Oberdoerffer, P., Dec 19 2015, In: Nucleic acids research. 44, 7, e64.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Double-Stranded DNA Breaks 100%
  • Transcriptome 80%
  • Epigenomics 30%
  • DNA Damage 30%
  • Gene Expression 20%

• Replication stress: A lifetime of epigenetic change

  Khurana, S. & Oberdoerffer, P., Sep 11 2015, In: Genes. 6, 3, p. 858-877 20 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • DNA Replication 100%
  • Chromatin 88%
  • Epigenomics 87%
  • Epigenome 62%
  • Double-Stranded DNA Breaks 57%

• Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease

  Oberdoerffer, P., Jan 2 2015, In: Molecular and Cellular Oncology. 2, 1, e970952.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chromatin 100%
  • Epigenomics 98%
  • DNA Damage 98%
  • Double-Stranded DNA Breaks 64%
• 2014

  A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance

  Khurana, S., Kruhlak, M. J., Kim, J., Tran, A. D., Liu, J., Nyswaner, K., Shi, L., Jailwala, P., Sung, M. H., Hakim, O. & Oberdoerffer, P., Aug 21 2014, In: Cell Reports. 8, 4, p. 1049-1062 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Poly(ADPribose) 100%
  • Chromatin 64%
  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 53%
  • Maintenance 51%
  • Genome 49%
• 2013

  Metabolic modulation of chromatin: Implications for DNA repair and genomic integrity

  Liu, J., Kim, J. & Oberdoerffer, P., 2013, In: Frontiers in Genetics. 4, SEP, Article 182.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • DNA Repair 100%
  • Chromatin 95%
  • Double-Stranded DNA Breaks 61%
  • Genomic Instability 59%
  • DNA Damage 47%

• Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

  Singh, S. K., Williams, C. A., Klarmann, K., Burkett, S. S., Keller, J. R. & Oberdoerffer, P., May 2013, In: Journal of Experimental Medicine. 210, 5, p. 987-1001 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuin 1 100%
  • Hematopoietic Stem Cells 74%
  • Epigenomics 65%
  • Maintenance 52%
  • Adult Stem Cells 21%
• 2012

  Chromatin dynamics in DNA double-strand break repair

  Shi, L. & Oberdoerffer, P., Jul 2012, In: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1819, 7, p. 811-819 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Double-Stranded DNA Breaks 100%
  • Chromatin 77%
  • Environment 49%
  • Modification 48%
  • Time 31%

• DNA damage, chromatin, and transcription: The trinity of aging

  Burgess, R. C., Misteli, T. & Oberdoerffer, P., Dec 2012, In: Current Opinion in Cell Biology. 24, 6, p. 724-730 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Chromatin 100%
  • Epigenomics 98%
  • DNA Damage 98%
• 2011

  CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

  Shukla, S., Kavak, E., Gregory, M., Imashimizu, M., Shutinoski, B., Kashlev, M., Oberdoerffer, P., Sandberg, R. & Oberdoerffer, S., Nov 3 2011, In: Nature. 479, 7371, p. 74-79 6 p.

  Research output: Contribution to journal › Article › peer-review

  • RNA Polymerase II 100%
  • Alternative Splicing 93%
  • DNA Methylation 84%
  • Exons 71%
  • CCCTC-Binding Factor 34%
• 2010

  An age of fewer histones

  Oberdoerffer, P., Nov 2010, In: Nature cell biology. 12, 11, p. 1029-1031 3 p.

  Research output: Contribution to journal › Short survey › peer-review

  • Histones 100%
  • Cell Division 50%
  • Chromatin 47%
  • DNA Damage 46%

• Dietary restriction: Standing up for sirtuins

  Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., De Cabo, R., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., Helfand, S. L., Imai, S. I., Itoh, H., Kadowaki, T., Koya, D., Leeuwenburgh, C., Mcburney, M., Nabeshima, Y. O. I., Neri, C., Oberdoerffer, P., & 13 othersPestell, R. G., Rogina, B., Sadoshima, J., Sartorelli, V., Serrano, M., Sinclair, D. A., Steegborn, C., Tatar, M., Tissenbaum, H. A., Tong, Q., Tsubota, K., Vaquero, A. & Verdin, E., Aug 27 2010, In: Science. 329, 5995, p. 1012-1013 2 p.

  Research output: Contribution to journal › Letter › peer-review
• 2009

  The ageing epigenome: Damaged beyond repair?

  Sinclair, D. A. & Oberdoerffer, P., Jul 2009, In: Ageing Research Reviews. 8, 3, p. 189-198 10 p.

  Research output: Contribution to journal › Short survey › peer-review

  • RNA Sequence 100%
  • Epigenome 91%
  • DNA Damage 64%
  • Mutation 62%
  • Error 54%
• 2008

  SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

  Oberdoerffer, P., Michan, S., McVay, M., Mostoslavsky, R., Vann, J., Park, S. K., Hartlerode, A., Stegmuller, J., Hafner, A., Loerch, P., Wright, S. M., Mills, K. D., Bonni, A., Yankner, B. A., Scully, R., Prolla, T. A., Alt, F. W. & Sinclair, D. A., Nov 28 2008, In: Cell. 135, 5, p. 907-918 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genomic Instability 100%
  • Histone 97%
  • Chromatin 80%
  • DNA Breaks 74%
  • Gene Expression 54%

• The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

  Firestein, R., Blander, G., Michan, S., Oberdoerffer, P., Ogino, S., Campbell, J., Bhimavarapu, A., Luikenhuis, S., de Cabo, R., Fuchs, C., Hahn, W. C., Guarente, L. P. & Sinclair, D. A., Apr 16 2008, In: PloS one. 3, 4, e2020.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intestinal Neoplasms 100%
  • Catenins 78%
  • Colonic Neoplasms 67%
  • Carcinogenesis 57%
  • Growth 37%
• 2007

  The role of nuclear architecture in genomic instability and ageing

  Oberdoerffer, P. & Sinclair, D. A., Sep 2007, In: Nature Reviews Molecular Cell Biology. 8, 9, p. 692-702 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Genomic Instability 100%
  • Chromatin 80%
  • Saccharomycetales 55%
  • Eukaryota 47%
  • Saccharomyces cerevisiae 41%
• 2005

  Efficiency of RNA interference in the mouse hematopoietic system varies between cell types and developmental stages

  Oberdoerffer, P., Kanellopoulou, C., Heissmeyer, V., Paeper, C., Borowski, C., Aifantis, I., Rao, A. & Rajewsky, K., May 2005, In: Molecular and cellular biology. 25, 10, p. 3896-3905 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoietic System 100%
  • RNA Interference 73%
  • Gene Targeting 29%
  • Gene Silencing 27%
  • bcl-2 Genes 16%

• The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

  Mandal, M., Borowski, C., Palomero, T., Ferrando, A. A., Oberdoerffer, P., Meng, F., Ruiz-Vela, A., Ciofani, M., Zuniga-Pflucker, J. C., Screpanti, I., Look, A. T., Korsmeyer, S. J., Rajewsky, K., Von Boehmer, H. & Aifantis, I., Feb 21 2005, In: Journal of Experimental Medicine. 201, 4, p. 603-614 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Thymocytes 100%
  • T-Cell Antigen Receptor 94%
  • T-Lymphocytes 38%
  • Genes 37%
  • T-Cell Leukemia 20%
• 2003

  Expression of a targeted λ1 light chain gene is developmentally regulated and independent of Igκ rearrangements

  Oberdoerffer, P., Novobrantseva, T. I. & Rajewsky, K., May 5 2003, In: Journal of Experimental Medicine. 197, 9, p. 1165-1172 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Joints 100%
  • Light 99%
  • Immunoglobulin Light Chains 96%
  • B-Lymphocyte Subsets 88%
  • Gene Rearrangement 82%

• Unidirectional Cre-mediated genetic inversion in mice using the mutant loxP pair lox66/lox71.

  Oberdoerffer, P., Otipoby, K. L., Maruyama, M. & Rajewsky, K., Nov 15 2003, In: Nucleic acids research. 31, 22, p. e140

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome 100%
  • Site-Directed Mutagenesis 78%
  • Transgenes 74%
  • Genetic Recombination 70%
  • DNA 41%