Research output per year
Research output per year
- 27 results
Search results
-
2023
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds
Yang, H., Ulge, U. Y., Quijano-Rubio, A., Bernstein, Z. J., Maestas, D. R., Chun, J. H., Wang, W., Lin, J. X., Jude, K. M., Singh, S., Orcutt-Jahns, B. T., Li, P., Mou, J., Chung, L., Kuo, Y. H., Ali, Y. H., Meyer, A. S., Grayson, W. L., Heller, N. M., Garcia, K. C., & 5 others, Sep 2023, In: Nature chemical biology. 19, 9, p. 1127-1137 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance
Warren, K. J., Deering-Rice, C., Huecksteadt, T., Trivedi, S., Venosa, A., Reilly, C., Sanders, K., Clayton, F., Wyatt, T. A., Poole, J. A., Heller, N. M., Leung, D. & Paine, R., Dec 2023, In: Biology of Sex Differences. 14, 1, 2.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Androgen-induced insulin resistance is ameliorated by deletion of hepatic androgen receptor in females
Andrisse, S., Feng, M., Wang, Z., Awe, O., Yu, L., Zhang, H., Bi, S., Wang, H., Li, L., Joseph, S., Heller, N., Mauvais-Jarvis, F., William Wong, G., Segars, J., Wolfe, A., Divall, S., Ahima, R. & Wu, S., Oct 2021, In: FASEB Journal. 35, 10, e21921.Research output: Contribution to journal › Article › peer-review
Open Access -
Sex differences in M2 polarization, chemokine and IL-4 receptors in monocytes and macrophages from asthmatics
Becerra-Díaz, M., Lerner, A. D., Yu, D. H., Thiboutot, J. P., Liu, M. C., Yarmus, L. B., Bose, S. & Heller, N. M., Feb 2021, In: Cellular Immunology. 360, 104252.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
Morphine decreases the function of primary human natural killer cells by both TLR4 and opioid receptor signaling
Maher, D. P., Walia, D. & Heller, N. M., Jan 2020, In: Brain, Behavior, and Immunity. 83, p. 298-302 5 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Reduced allergic lung inflammation and airway responsiveness in mice lacking the cytoskeletal protein gelsolin
Mikami, M., Yocum, G. T., Heller, N. M. & Emala, C. W., Nov 3 2020, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 319, 5, p. L833-L842Research output: Contribution to journal › Article › peer-review
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2019
Suppression of Human Natural Killer Cells by Different Classes of Opioids
Maher, D. P., Walia, D. & Heller, N. M., 2019, In: Anesthesia and analgesia. 128, 5, p. 1013-1021 9 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2018
Androgen and Androgen Receptor as Enhancers of M2 Macrophage Polarization in Allergic Lung Inflammation
Becerra-Diaz, M., Strickland, A. B., Keselman, A. & Heller, N. M., Nov 15 2018, In: Journal of Immunology. 201, 10, p. 2923-2933 11 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Female sex and gender in lung/sleep health and disease: Increased understanding of basic biological, pathophysiological, and behavioral mechanisms leading to better health for female patients with lung disease
Han, M. L. K., Arteaga-Solis, E., Blenis, J., Bourjeily, G., Clegg, D. J., DeMeo, D., Duffy, J., Gaston, B., Heller, N. M., Hemnes, A., Henske, E. P., Jain, R., Lahm, T., Lancaster, L. H., Lee, J., Legato, M. J., McKee, S., Mehra, R., Morris, A., Prakash, Y. S., & 7 others, Oct 1 2018, In: American journal of respiratory and critical care medicine. 198, 7, p. 850-858 9 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2017
Alternative activation-skewed microglia/macrophages promote hematoma resolution in experimental intracerebral hemorrhage
Chang, C. F., Wan, J., Li, Q., Renfroe, S. C., Heller, N. M. & Wang, J., Jul 1 2017, In: Neurobiology of Disease. 103, p. 54-69 16 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Estrogen signaling contributes to sex differences in macrophage polarization during asthma aleksander keselman1
Fang, X., White, P. B. & Heller, N. M., Sep 1 2017, In: Journal of Immunology. 199, 5, p. 1573-1583 11 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
2016
Enhanced resolution of experimental ards through il-4-mediated lung macrophage reprogramming
D’Alessio, F. R., Craig, J. M., Singer, B. D., Files, D. C., Mock, J. R., Garibaldi, B. T., Fallica, J., Tripathi, A., Mandke, P., Gans, J. H., Limjunyawong, N., Sidhaye, V. K., Heller, N. M., Mitzner, W., King, L. S. & Aggarwal, N. R., Apr 15 2016, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 310, 8, p. L733-L746Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension
Johns, R. A., Takimoto, E., Meuchel, L. W., Elsaigh, E., Zhang, A., Heller, N. M., Semenza, G. L. & Yamaji-Kegan, K., Jan 1 2016, In: Arteriosclerosis, thrombosis, and vascular biology. 36, 1, p. 134-144 11 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Suppressor of cytokine signaling (SOCS)1 regulates interleukin-4 (IL-4)-activated insulin receptor substrate (IRS)-2 tyrosine phosphorylation in monocytes and macrophages via the proteasome
McCormick, S. M., Gowda, N., Fang, J. X. & Heller, N. M., Sep 23 2016, In: Journal of Biological Chemistry. 291, 39, p. 20574-20587 14 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations -
The TORC1-activated proteins, p70S6K and GRB10, regulate IL-4 signaling and M2 macrophage polarization by modulating phosphorylation of insulin receptor substrate-2
Warren, K. J., Fang, X., Gowda, N. M., Thompson, J. J. & Heller, N. M., Nov 25 2016, In: Journal of Biological Chemistry. 291, 48, p. 24922-24930 9 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2015
Commentary: IL-4 and IL-13 receptors and signaling
McCormick, S. M. & Heller, N. M., Sep 1 2015, In: Cytokine. 75, 1, p. 38-50 13 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation
Berga-Bolaños, R., Sharma, A., Steinke, F. C., Pyaram, K., Kim, Y. H., Sultana, D. A., Fang, J. X., Chang, C. H., Xue, H. H., Heller, N. M. & Sen, J. M., Oct 19 2015, In: BMC Immunology. 16, 1, 62.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2012
IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro
Heller, N. M., Gwinn, W. M., Donnelly, R. P., Constant, S. L. & Keegan, A. D., Jun 28 2012, In: PloS one. 7, 6, e39673.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13
Heller, N. M., Qi, X., Gesbert, F. & Keegan, A. D., Sep 14 2012, In: Journal of Biological Chemistry. 287, 38, p. 31948-31961 14 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2009
An atopy-associated polymorphism in the ectodomain of the IL-4Rα chain (V50) regulates the persistence of STAT6 phosphorylation
Ford, A. Q., Heller, N. M., Stephenson, L., Boothby, M. R. & Keegan, A. D., Aug 1 2009, In: Journal of Immunology. 183, 3, p. 1607-1616 10 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
2008
Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
LaPorte, S. L., Juo, Z. S., Vaclavikova, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D. & Garcia, K. C., Jan 25 2008, In: Cell. 132, 2, p. 259-272 14 p.Research output: Contribution to journal › Article › peer-review
Open Access341 Scopus citations -
Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages
Heller, N. M., Qi, X., Junttila, I. S., Shirey, K. A., Vogel, S. N., Paul, W. E. & Keegan, A. D., Dec 23 2008, In: Science signaling. 1, 51, p. ra17Research output: Contribution to journal › Article › peer-review
98 Scopus citations -
2004
Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells
Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Stellato, C. & Schleimer, R. P., Nov 2004, In: Clinical and Experimental Allergy. 34, 11, p. 1690-1700 11 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Interferon-γ inhibits STAT6 signal transduction and gene expression in human airway epithelial cells
Heller, N. M., Matsukura, S., Georas, S. N., Boothby, M. R., Rothman, P. B., Stellato, C. & Schleimer, R. P., Nov 2004, In: American journal of respiratory cell and molecular biology. 31, 5, p. 573-582 10 p.Research output: Contribution to journal › Article › peer-review
56 Scopus citations -
Variation in dinucleotide (GT) repeat sequence in the first exon of the STAT6 gene is associated with atopic asthma and differentially regulates the promoter activity in vitro
Gao, P. S., Heller, N. M., Walker, W., Chen, C. H., Moller, M., Plunkett, B., Roberts, M. H., Schleimer, R. P., Hopkin, J. M. & Huang, S. K., Jul 2004, In: Journal of medical genetics. 41, 7, p. 535-539 5 p.Research output: Contribution to journal › Article › peer-review
Open Access50 Scopus citations -
2003
Detection and quantitation of fatty acid acyl conjugates of triamcinolone acetonide via gas chromatography-electron-capture negative-ion mass spectrometry
Hubbard, W. C., Blum, A. E., Bickel, C. A., Heller, N. M. & Schleimer, R. P., 2003, In: Analytical biochemistry. 322, 2, p. 243-250 8 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells
Kurosawa, S., Myers, A. C., Chen, L., Wang, S., Ni, J., Plitt, J. R., Heller, N. M., Bochner, B. S. & Schleimer, R. P., May 1 2003, In: American journal of respiratory cell and molecular biology. 28, 5, p. 563-573 11 p.Research output: Contribution to journal › Article › peer-review
36 Scopus citations